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Hybrid silica gel for extracting hydrotropic substance in tranquilizer and preparation method thereof, and extraction method of hydrotropic substance in tranquilizer by adopting hybrid silica gel

A technology of hybrid silica gel and sedative medicine, which is applied in the direction of chemical instruments and methods, preparation of test samples, and other chemical processes. It can solve laborious and time-consuming problems, achieve good adsorption capacity, and simple operation process.

Active Publication Date: 2020-03-27
NINGBO UNIVERSITY OF TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method is not only time-consuming and laborious, but also involves a large amount of organic solvents

Method used

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  • Hybrid silica gel for extracting hydrotropic substance in tranquilizer and preparation method thereof, and extraction method of hydrotropic substance in tranquilizer by adopting hybrid silica gel
  • Hybrid silica gel for extracting hydrotropic substance in tranquilizer and preparation method thereof, and extraction method of hydrotropic substance in tranquilizer by adopting hybrid silica gel
  • Hybrid silica gel for extracting hydrotropic substance in tranquilizer and preparation method thereof, and extraction method of hydrotropic substance in tranquilizer by adopting hybrid silica gel

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Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0032] The preparation method of the present embodiment 1~3 hybrid silica gel:

[0033] 1) Preparation of matrix material: Weigh 320mg cetyltrimethylammonium bromide (CTAB) into a 50mL plastic centrifuge tube, add 4.48mL tetraethoxysilane, 4.72mL aminopropyltriethoxysilane, 4000 mg of dimethyloctadecyl[3-trimethoxysilylpropyl]ammonium chloride and 8.7 mL of absolute ethanol, shaken with a vortex mixer, followed by water bath at 30 °C until cetyltrimethyl bromide The ammonium was completely dissolved, and then 1.28 mL of water was added, mixed with a vortex mixer, and reacted in a water bath at 40°C for 24 hours to form a matrix material.

[0034] 2) After the reaction is completed, rinse with 25 mL of absolute ethanol for 3 times to remove unreacted CTAB, then rinse with pure water for 1 time, and then add 20 mL of 10% (W / V) poly(ethylene glycol) 4-nonyl Phenyl-3-thiopropyl ether potassium salt (NSEP) aqueous solution, react at 70°C for 24 hours to obtain a hybrid silica gel ...

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Abstract

The invention discloses a hybrid silica gel containing a poly(ethylene glycol) hydrophilic group. The preparation process of the hybrid silica gel comprises the following steps of: taking absolute ethyl alcohol as a solvent, adding hexadecyl trimethyl ammonium bromide, tetraethoxysilane, aminopropyltriethoxysilane and dimethyloctadecyl[3-trimethoxysilylpropyl]ammonium chloride, and performing reaction to obtain a host material; adding a poly (ethylene glycol) 4-nonylphenyl-3-sulfopropyl ether potassium salt aqueous solution into the host material, performing reaction, and obtaining the hybridsilica gel containing the poly(ethylene glycol) hydrophilic group, thereby satisfying the extraction and determination of hydrophilic substances.

Description

technical field [0001] The invention relates to hybrid silica gel, in particular to a hybrid silica gel for extracting hydrophilic substances in tranquilizers, a preparation method and an extraction method thereof. Background technique [0002] Tranquilizers contain hydrophilic substances such as melatonin, barbital, phenobarbital, amobarbital, clomezalone, clonazepam, oxazepam, etc. These substances are polar and weak Polar, soluble in organic solvents. At present, the determination method of tranquilizing medicine mainly adopts the liquid-liquid extraction technique, that is, the hydrophilic substance in the tranquilizing medicine is extracted through a solvent, then dried with nitrogen gas, and then redissolved with the mobile phase of HPLC. This method is not only time-consuming and laborious, but also involves a large amount of organic solvents. [0003] Solid phase extraction (SPE) is a method of selective adsorption and selective elution to enrich, separate and puri...

Claims

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Application Information

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IPC IPC(8): B01J20/22B01J20/30B01D15/08G01N1/28
CPCB01J20/22B01J20/103B01D15/08G01N1/28B01J2220/4806B01J2220/4812
Inventor 王婷婷李露青陈易晖周建立李勰仇丹陈树兵李向东汪尚游
Owner NINGBO UNIVERSITY OF TECHNOLOGY
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