Double-network hydrogel based on poly-N-acrylylglycinamide and sodium alginate, and preparation method thereof

A technology of polyacryloyl glycinamide and acryloyl glycinamide, which is applied in the field of double network hydrogel based on polyacryloyl glycinamide and sodium alginate and its preparation, can solve the problem of weak mechanical properties of hydrogel, Low energy dissipation mechanism, hydrogel application limitations and other issues, to achieve the effect of broadening the preparation method and broad application prospects

Inactive Publication Date: 2020-03-17
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, hydrogel is a porous network structure with a large amount of water inside, and the polymer chain segments are in a highly swollen state in water. During the stress process, these chain segments show greater brittleness and stronger The low energy dissipation mechanism leads to weak mechanical properties of hydrogels, which greatly limits the application of hydrogels

Method used

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  • Double-network hydrogel based on poly-N-acrylylglycinamide and sodium alginate, and preparation method thereof
  • Double-network hydrogel based on poly-N-acrylylglycinamide and sodium alginate, and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Step 1, put 6.0g of glycinamide hydrochloride, 6mL of deionized water, 32mL of 2mol / L potassium carbonate and 16mL of diethyl ether in a reaction vessel and mix in an ice bath, then mix 5.0g of acryloyl chloride with 20mL of diethyl ether and slowly drop Added to the above reaction solution, the dropwise addition time was 0.5h, and then stirred and reacted under ice bath for 3h after the dropwise addition, the pH of the reaction solution was adjusted to 1, after washing with ether, the pH of the reaction solution was adjusted to 6, and the The reaction solution was freeze-dried, washed with ethanol / methanol mixed solvent (the ratio of ethanol to methanol was 4:1), rotary evaporated, and dried to obtain acryloyl glycinamide (NAGA);

[0022] Step 2, dissolve 0.171 g of acryloyl glycinamide (NAGA) and 0.029 g of sodium alginate (alginate) obtained above into 800 μL of water to obtain a mixed solution of acryloyl glycinamide (NAGA) and sodium alginate (alginate) , the mass ...

Embodiment 2

[0024] Step 1, put 7.0g of glycinamide hydrochloride, 6mL of deionized water, 35mL of 2mol / L potassium carbonate and 20mL of diethyl ether in a reaction vessel and mix in an ice bath, then mix 6.5g of acryloyl chloride with 30mL of diethyl ether and slowly drop Add it to the above reaction solution, and the dropwise addition time is 1.5h. After the dropwise addition, stir and react in an ice bath for 5h, and adjust the pH of the reaction solution to 3. After washing with ether, adjust the pH of the reaction solution to 7. The reaction solution was freeze-dried, washed with ethanol / methanol mixed solvent (the ratio of ethanol to methanol was 4:1), rotary evaporated, and dried to obtain acryloyl glycinamide (NAGA);

[0025] Step 2, dissolve 0.178g of acryloyl glycinamide (NAGA) and 0.022g of sodium alginate (alginate) obtained above into 800 μL of water to obtain a mixed solution of acryloyl glycinamide (NAGA) and sodium alginate (alginate) , the mass ratio of acryloyl glycinami...

Embodiment 3

[0027]Step 1, put 6.3g of glycinamide hydrochloride, 6mL of deionized water, 33.6mL of 2mol / L potassium carbonate and 18mL of diethyl ether in a reaction vessel and mix in an ice bath, then mix 5.7g of acryloyl chloride with 24mL of diethyl ether and slowly Add dropwise into the above reaction solution, the dropwise time is 1h, and then stir and react under ice bath for 4h, adjust the pH of the reaction solution to 2, after washing with ether, adjust the pH of the reaction solution to 7, and then The reaction solution was freeze-dried, washed with ethanol / methanol mixed solvent (the ratio of ethanol to methanol was 4:1), rotary evaporated, and dried to obtain acryloyl glycinamide (NAGA);

[0028] Step 2, dissolving 0.182 g of acryloyl glycinamide (NAGA) and 0.018 g of sodium alginate (alginate) obtained above into 800 μL of water to obtain a mixed solution of acryloyl glycinamide (NAGA) and sodium alginate (alginate) , the mass ratio of acryloyl glycinamide (NAGA) to sodium al...

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Abstract

The invention provides a double-network hydrogel based on poly-N-acrylylglycinamide and sodium alginate, and a preparation method thereof. The preparation method comprises the following steps: preparing N-acrylylglycinamide (NAGA) from glycinamide and acryloyl chloride, blending the N-acrylylglycinamide (NAGA) monomer with a sodium alginate solution, adding a thermal initiator, carrying out a copolymerization reaction, and soaking the obtained gel in a Ca<2+> solution to obtain the double-network hydrogel based on poly-N-acrylylglycinamide and sodium alginate. The double-network hydrogel basedon poly-N-acrylylglycinamide and sodium alginate is composed of hydrogen bonds and ionic bonds, the strong hydrogen bond interaction of N-acrylylglycinamide in the hydrogel makes the hydrogel have stable water soaking and high strength, and the introduction of sodium alginate makes the mechanical properties of the hydrogel continued to a certain extent through ionic crosslinking.

Description

technical field [0001] The invention relates to the technical field of double-network high-strength hydrogel preparation, in particular to a double-network hydrogel based on polyacryloyl glycinamide and sodium alginate and a preparation method thereof. Background technique [0002] Polymer hydrogel is a kind of three-dimensional network structure containing a large amount of water inside. It has a great similarity with the soft tissue in the body in terms of structure and shape, and polymer hydrogel generally has good biocompatibility, so water Gels have been widely used in various fields such as tissue engineering scaffolds, drug delivery vehicles, and wound dressings. However, hydrogel is a porous network structure with a large amount of water inside, and the polymer chain segments are in a highly swollen state in water. During the stress process, these chain segments show greater brittleness and stronger The low energy dissipation mechanism leads to weak mechanical prope...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/26C08L5/04C08F120/60C08F2/44C08J3/24C08J3/075
CPCC08F2/44C08F120/60C08J3/075C08J3/24C08J2333/26C08J2405/04C08L33/26C08L5/04
Inventor 刘文广范川川
Owner TIANJIN UNIV
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