Dissociation method and application of titanium complex drug

Abstract

The invention discloses a dissociation method and application of a titanium complex drug. According to the dissociation method, the stronger coordination property of citric acid and metal ions is utilized, the citric acid competes with drug molecules for coordination of titanium ions, the drug molecules complexed in the titanium complexation drug are released, and then separation operation is performed to collect the released drug molecules. According to the dissociation method disclosed by the invention, the purity of the drug compound can be obviously improved, because the citric acid can becompletely complexed with the titanium ions, a titanium complex formed by the drug molecules and the titanium ions is disintegrated, and then the dissociated drug compound is directly concentrated and collected through separation operation, so that the drug compound is obtained. The method is simple and efficient, the obtained drug compound has fewer impurities and higher purity, and the qualityof the drug is obviously improved.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to a dissociation method of a titanium complex drug and its application. Background technique [0002] Any substance that affects the purity of a drug is collectively referred to as an impurity. Impurity research is an important part of drug development. It includes selecting appropriate analytical methods, accurately distinguishing and measuring the content of impurities, and comprehensively determining the reasonable limits of impurities based on the results of pharmaceutical, toxicological and clinical research. This research runs through the entire process of drug development. The adverse reactions of drugs in clinical use are not only related to the pharmacological activity of the drug itself, but also sometimes have a lot to do with the impurities in the drug. For example, high-molecular impurities such as polymers in antibiotics such as penicillin are the main ...

AI Technical Summary

Problems solved by technology

[0005] However, because of the unique coordination properties of titanium ions, it also brings disadvantages to the chemical synthesis of drugs.

For example, in the synthesis of titanium tetrachloride, complexation between titanium ions and compound molecules often occurs, and the formed complexes are easier to dissolve in water, which increases the difficulty of product purification, resulting in low yields of drug synthesis and environmental pollution. At the same time, the titanium complex formed by some drug molecules and titanium ions enters the organic phase and is mixed into the drug molecules as impurities, which is difficult to remove and ultimately affects the quality of the drug.

[0006] In existing methods, the separation and purification of the target substance must be carried out, and the operation is cumbersome. Therefore, there are problems such as low yield of the target substance and failure to provide products with good quality. It is urgent to solve these problems

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