Cold-coagulation-blood-stasis-syndrome-resistant differential metabolite metabolic pathway and study method of Chinese angelica-based cold-coagulation blood-stasis treatment decoction

A technology of cold blood stasis and Sini decoction, applied in the field of medical analysis, can solve problems such as slowness and achieve the effect of high diagnostic value

Inactive Publication Date: 2020-02-14
GUANGXI MEDICAL UNIVERSITY
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Since the development of BSS is a slow and dynamic process, the intervent

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  • Cold-coagulation-blood-stasis-syndrome-resistant differential metabolite metabolic pathway and study method of Chinese angelica-based cold-coagulation blood-stasis treatment decoction
  • Cold-coagulation-blood-stasis-syndrome-resistant differential metabolite metabolic pathway and study method of Chinese angelica-based cold-coagulation blood-stasis treatment decoction
  • Cold-coagulation-blood-stasis-syndrome-resistant differential metabolite metabolic pathway and study method of Chinese angelica-based cold-coagulation blood-stasis treatment decoction

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[0055] The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0056] A metabolic pathway and research method of differential metabolites of Danggui Sini Decoction in the treatment of cold coagulation and blood stasis syndrome based on dynamic urine metabolomics, using ultra-high performance liquid chromatography-tandem mass spectrometry to detect and analyze female rats induced by ice water bath + adrenaline Fingerprints of endogenous metabolites formed at different time points after the formation of cold coagulation and blood stasis syndrome and the intervention of Danggui Sini Decoction were obtained.

[0057] Using the method of multivariate statistical analysis, 21 metabolites with significant changes were screened and identified from multiple variables, as differential metabolites potentially related to the occurrence and developmen...

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Abstract

The invention discloses a cold-coagulation-blood-stasis-syndrome-resistant differential metabolite metabolic pathway and study method of a Chinese angelica-based cold-coagulation blood-stasis treatment decoction. The method comprises: detecting and analyzing endogenous metabolites changed at different time points after cold-coagulation blood-stasis symptoms forming of a female rat under an ice-water bath and epinephrine induction and Chinese angelica-based cold-coagulation blood-stasis treatment decoction intervention by using an ultra-high performance liquid chromatography tandem mass spectrometry so as to obtain a fingerprint spectrum; with a multivariate variable statistical analysis method, carrying out screening from a plurality of variables and identifying 21 significantly changed metabolites; and enriching eight metabolic pathways related to different development stages of the cold-coagulation blood-stasis symptom by using ametaboanalyst open-source online metabonomics analysiswebsite. According to the invention, the related metabolic changes in the occurrence and development process of the old-coagulation blood-stasis symptoms and the treatment process of the Chinese angelica-based cold-coagulation blood-stasis treatment decoction are studied by using a dynamic analysis method; the disease occurrence and development mechanisms at different time points can be revealed;and the abnormal metabolic network regulated and controlled by medicines in the treatment process can be clarified.

Description

technical field [0001] The invention relates to the technical field of medical analysis. More specifically, the present invention relates to Danggui Sini Decoction differential metabolite metabolic pathways and research methods for anti-cold coagulation and blood stasis syndrome. Background technique [0002] Metabonomics has the characteristics of "whole-dynamic-comprehensive", which is consistent with the pathogenesis of complex diseases and the onset characteristics of traditional Chinese medicine. Metabolomics is a new technology developed in recent years for qualitative and quantitative analysis of dynamic metabolite changes in biological systems. The change. The metabolomics research process usually includes biological sample collection, pretreatment, sample analysis, data processing, identification of markers, and interpretation of biological significance. Its technologies mainly include nuclear magnetic resonance (NMR), gas chromatography-mass spectrometry (GS / MS)...

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IPC IPC(8): G01N30/88G01N30/06G01N30/86
CPCG01N30/06G01N30/8686G01N30/88
Inventor 苏志恒黄慧敏吴金霞郑华程邦宋慧郭宏伟梁永红
Owner GUANGXI MEDICAL UNIVERSITY
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