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Quality control method and device in metabolomics and storage medium

A quality control method and metabolomics technology, applied in the fields of informatics, biostatistics, bioinformatics, etc., can solve the problems of low accuracy of data analysis results and abnormal QC samples, so as to improve accuracy and repeatability. sexual effect

Pending Publication Date: 2020-02-11
SUZHOU BIONOVOGENE BIOMEDICAL TECH CO LTD
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Problems solved by technology

[0007] This application provides a quality control method, device and storage medium in metabolomics, which can solve the problem that the abnormality of QC samples leads to low accuracy of data analysis results of non-targeted metabolomics

Method used

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  • Quality control method and device in metabolomics and storage medium
  • Quality control method and device in metabolomics and storage medium
  • Quality control method and device in metabolomics and storage medium

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Embodiment Construction

[0048] The specific implementation manners of the present application will be further described in detail below in conjunction with the drawings and embodiments. The following examples are used to illustrate the present application, but not to limit the scope of the present application.

[0049] First, some terms involved in this application are introduced.

[0050] Principal Component Analysis (PCA): It is a data dimensionality reduction algorithm. The principle of PCA includes: mapping n-dimensional features to k-dimensional, and k-dimensional features are brand new orthogonal features. The k-dimensional feature is also called the principal component, which is a k-dimensional feature reconstructed on the basis of the original n-dimensional feature.

[0051]The goal of PCA is to replace a large number of correlated variables with a small set of uncorrelated variables while retaining as much information as possible from the initial variables. These derived variables are call...

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Abstract

The invention relates to a quality control method and device in metabolomics and a storage medium, which belong to the technical field of metabolomics analysis. The method comprises the steps that experimental samples are equivalently extracted and mixed to acquire quality control samples; the sample information of the quality control samples is acquired, wherein the sample information includes aprincipal component analysis chart, an experimental sample, the fluctuation trend chart of the quality control samples and / or the first principal component value of the quality control samples; basedon the sample information, abnormal samples in the quality control samples are filtered out to obtain the screened quality control samples; and the screened quality control samples are used for standardization correction. The problem of abnormalities in QC samples can be solved. The repeatability of QC samples is improved. The accuracy of data analysis results for non-targeted metabolomics is improved.

Description

technical field [0001] The application relates to a quality control method, device and storage medium in metabolomics, belonging to the technical field of metabonomics analysis. Background technique [0002] Metabolomics (metabolomics or metabonomics) is a research method that imitates the research ideas of genomics and proteomics, conducts quantitative analysis of all metabolites in organisms, and searches for the relative relationship between metabolites and physiological and pathological changes. component. The research process of metabolomics includes: experimental design, sample processing, data acquisition and data analysis. [0003] Metabolomics can be divided into non-targeted metabolomics and targeted metabolomics. Among them, non-targeted metabolomics refers to unbiased detection of all metabolite molecules that can be detected in samples, differential analysis and pathway analysis through bioinformatics methods to find biomarkers, and preliminary establishment o...

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Application Information

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IPC IPC(8): G16B5/00G16B40/00G06K9/62
CPCG16B5/00G16B40/00G06F18/2135Y02P90/30
Inventor 周浩昆任建洪
Owner SUZHOU BIONOVOGENE BIOMEDICAL TECH CO LTD
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