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High-precision magnetic nano temperature estimation method and system based on Fokker-Planck

A magnetic nano, high-precision technology, applied in the field of nano-magnetic detection technology and non-invasive temperature measurement, can solve the problems of low magnetic nano-temperature measurement accuracy, spatial resolution, and low measurement accuracy

Active Publication Date: 2020-01-17
ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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  • Description
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Problems solved by technology

[0005] Aiming at the influence of the Brownian or Neel magnetization phenomenon on the harmonic amplitude information of the magnetization response under the medium-high frequency magnetic field excitation, the Langevin function cannot accurately describe the magnetization response information of the magnetic nanoparticle size under the medium-high frequency excitation. For the technical problem of low measurement accuracy, the present invention proposes a high-precision magnetic nanometer temperature estimation method and system based on Fokker-Planck, which compensates the harmonic amplitude information of the magnetization response through the harmonic amplitude and phase information in the magnetization response , so that it can accurately describe the harmonic information of the magnetic nanoparticle magnetization response under the excitation of the medium and high frequency magnetic field, and then realize the estimation of the temperature information under the excitation of the medium and high frequency magnetic field, and overcome the magnetic nanometer temperature measurement accuracy and spatial resolution caused by the low excitation frequency in the past It is expected to realize real-time temperature information measurement under the excitation of medium and high frequency magnetic fields, so as to meet the measurement accuracy, real-time performance and performance of magnetic nanometer temperature measurement and magnetic nanoparticle imaging technology required by medical biological diagnosis and industrial fields. Requirements for indicators such as spatial resolution

Method used

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  • High-precision magnetic nano temperature estimation method and system based on Fokker-Planck

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Embodiment 1

[0067] Example 1, such as figure 1 As shown, a high-precision magnetic nanometer temperature estimation method based on Fokker-Planck includes the following steps:

[0068] Step 1: Place the magnetic field information detection device on the magnetic nano sample to be detected to detect the magnetization response signal of the magnetic nano particles in the magnetic nano sample.

[0069]Magnetic nano samples include magnetic nano solid powder particles, magnetic nano colloids or magnetic nano liquids, and are suitable for magnetic nano particle temperature measurement systems including magnetic field excitation devices and magnetic field information detection devices. Magnetic nano samples are placed in the measurement system. The excitation device applies a medium and high frequency excitation magnetic field to the magnetic nano sample.

[0070] The magnetic field excitation device uses an energized Helmholtz coil, a solenoid or a Maxwell coil to generate a medium-high frequ...

Embodiment 2

[0112] A high-precision magnetic nanometer temperature estimation system based on Fokker-Planck, including a magnetic field excitation device, a magnetic field information detection device, and a signal processing and temperature calculation device. area, the magnetic field excitation device generates an excitation magnetic field in the area where the magnetic nano sample to be detected is located, the magnetic field information detection device collects and preprocesses the magnetization response signal generated by the magnetic nano sample, the magnetic field information detection device and signal processing are connected with the temperature calculation device, The signal processing and temperature calculation device calculates the magnetic nanometer temperature information according to the magnetic nanoparticle temperature estimation model and the obtained magnetization response signal.

[0113] The magnetic field excitation device includes a magnetic field generator, a po...

experiment example 1

[0126] 1. Experimental conditions

[0127] In order to study the effectiveness and superiority of the present invention, three groups of experiments are carried out, the first group of experimental parameters: the sample model is SHP-20, Boltzmann's constant k B =1.38×10 -23 JK -1 , vacuum permeability μ 0 =1, the absolute temperature T=290K, the excitation magnetic field frequency is 200Hz, the sampling rate is 100KHz, the range of AC magnetic field strength is 0.002Tesla-0.01Tesla, the step is 0.001Tesla, the second set of experimental parameters: Sample model is MS1, Boltzmann constant k B =1.38×10 -23 JK -1 , vacuum permeability μ 0 =1, absolute temperature T=290K, frequency of excitation magnetic field is 200Hz, sampling rate is 100KHz, range of AC magnetic field strength is 0.002Tesla-0.01Tesla, step is 0.001Tesla, the third set of experimental parameters: Sample model is MS2, Boltzmann constant k B =1.38×10 -23 JK -1 , vacuum permeability μ 0 =1, the absolute...

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Abstract

The invention provides a high-precision magnetic nano temperature estimation method and system based on Fokker-Planck. The method comprises: constructing a magnetic nanoparticle temperature estimationmodel through a Fokker-Planck formula, measuring the magnetization response harmonic amplitude and phase information of the magnetic nanoparticles multiple times through a magnetic field informationdetection device, and fitting model parameters in the magnetic nanoparticle temperature estimation model; placing a sample to be detected in the magnetic field information detection device, measuringand substituting the harmonic amplitude and phase information of the sample under the excitation of an external magnetic field into the preset magnetic nanoparticle temperature estimation model, and solving the magnetic nanoparticle temperature information. According to the invention, the temperature information of the magnetic nanoparticles under the excitation of a medium-high frequency magneticfield can be accurately obtained. The problem that the conventional Langevin Function is not suitable on occasions of medium-high frequency excitation is solved, the application fields of magnetic nano temperature measurement and magnetic nano particle imaging technologies are expanded, and the measurement precision and the time-space resolution are improved.

Description

technical field [0001] The invention relates to the technical field of nanomagnetic detection technology and non-invasive temperature measurement, in particular to a high-precision magnetic nanometer temperature estimation method and system based on Fokker-Planck, which is suitable for magnetic nanometer temperature measurement or magnetic Nanoparticle imaging technology solves the bottleneck in the application field caused by the low excitation magnetic field of magnetic nanometer temperature measurement. Background technique [0002] Magnetic nanoparticle tumor hyperthermia is considered to be a green therapy for tumors and cancers due to its advantages of strong targeting, non-invasiveness, safety and less toxic side effects. Temperature is a very critical physical parameter in magnetic nano-tumor hyperthermia. However, the real-time and accurate measurement of temperature information in the cancerous tumor area is an important prerequisite and basis for precise applicat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F30/20G01R33/12G06F119/08G06F119/14
CPCG01R33/1215G01R33/1276
Inventor 杜中州叶娜孙毅王丹丹苏日建刘文中甘勇李娜娜邹东尧金保华朱付保张志峰
Owner ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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