Continuous synthesis for oseltamivir phosphate

Abstract

The invention discloses a preparation method for an oseltamivir phosphate compound, and belongs to the field of organic chemistry. The method is a continuous and automated method for producing compounds. The preparation method includes the following processes: preparing a solution, performing a reaction, performing mixing, performing centrifuging, performing stirring, performing heating, performing decoloring, performing cooling, and performing centrifuging and drying. Reactants are conveyed by using a metering diaphragm pump, the output of a product is adjusted by adjusting the conveying speed, and the target product is finally obtained by centrifugal drying. The preparation method greatly shortens the production cycle, reduces the manual use, improves the safety in the production process, and reduces the use of materials.

Description

technical field [0001] The invention belongs to the field of organic chemistry, and in particular relates to a continuous oseltamivir phosphate compound and a preparation method thereof. Background technique [0002] Influenza is an acute respiratory infection caused by RNA (Ribonucleic Acid, ribonucleic acid) virus. There are many ways of its transmission, such as airborne transmission, human-to-human contact transmission or contact with contaminated objects for transmission, etc., and has a very high mortality rate in critically ill patients. Moreover, the mutation rate of influenza virus is extremely high and highly contagious, and genes are easy to reassort and mutate. Once influenza breaks out, it will cause huge death and property loss. It is known that 10%-20% of people in the United States are affected every year, and at least more than 10,000 people are killed each year, causing economic losses of up to 100 million U.S. dollars. [0003] After the influenza virus ...

AI Technical Summary

Problems solved by technology

This method has a long preparation period and cumbersome preparation steps. In the laboratory test, solutions such as strong acid and strong alkali are used, and the safety requirements of the experiment are high, so it is not suitable for large-scale industrial production.

[0007] In order to improve the synthesis yield of oseltamivir phosphate, researchers have carried out a lot of research, but the preparation methods at home and abroad still have low yield, high cost, long production cycle, use of toxic and explosive products in the preparation process, and the heavy metal content of the product is not high. Problems such as reaching the standard, can't satisfy people's demand to the output of oseltamivir, therefore, need to provide a kind of production cost low, the preparation method of high output and yield urgently now

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