Convenient-to-use intestinal static replacement experimental device

Abstract

The invention provides a convenient-to-use intestinal static replacement experimental device. The device comprises an intestinal assembly simulating the large intestine shape of a human or animal, wherein an intestinal cavity bottom plate of the intestinal assembly is connected with a dome-shaped intestinal wall provided with a plurality of protruding quasi-ring bags and quasi-ring folds, the dome-shaped intestinal wall is provided with a gas inlet connector for nitrogen injection, a gas discharging opening discharges oxygen to from an oxygen-free environment, an edged bottle cover is installed on an intestinal cavity upper opening of the dome-shaped intestinal wall in a matched mode, the edged bottle cover is provided with a sample feeding pipeline and a sample taking pipeline for fillingan experimental sample into or sucking the experimental sample out of the intestinal assembly, a sample-discharging lower opening and a lower opening rubber plug provided with multiple probes are installed on the lower edge of the dome-shaped intestinal wall, a temperature control water sleeve provided with a water bath sealed bin is arranged around the intestinal assembly in a wrapping mode, temperature is controlled in the way that a water bath inlet and a water bath outlet are connected with a water pump and a water heater outside, and the outer surface of the temperature control water sleeve is tightly wrapped in a thermal insulation soft pad. The device has the advantages that an in-vivo experiment can be replaced with a convenient-to-perform and fast in-vitro static replacement experiment on the digestion function in intestines with low cost and high efficiency, and the requirements for standard scientific research and application are met.

Description

technical field [0001] The invention relates to a convenient intestinal static substitution experiment device. Background technique [0002] Due to food nutrition, functional active substance metabolism research, drug release kinetics research, probiotics and prebiotics, food toxicology research, animal nutrition and feed research and other natural science research, more and more scientific research requires digestion and absorption. Experiments are used to predict or evaluate the digestibility, bioavailability, release kinetics, and structural changes of compounds. In the digestion and absorption experiments of scientific research in the past, human or animal living bodies were often used for experiments. Secondly, due to the great individual differences in living body experiments, and the intestinal environment of the living body during the experiment cannot completely guarantee the normal environment, the experimental samples taken out for scientific research after the ex...

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Problems solved by technology

[0002] Due to food nutrition, functional active substance metabolism research, drug release kinetics research, probiotics and prebiotics, food toxicology research, animal nutrition and feed research and other natural science research, more and more scientific research requires digestion and absorption. Experiments are used to predict or evaluate the digestibility, bioavailability, release kinetics, and structural changes of compounds. In the digestion and absorption experiments of scientific research in the past, human or animal living bodies were often used for experiments. Secondly, due to the great individual differences in living body experiments, and the intestinal environment of the living body during the experiment cannot completely guarantee the normal environment, the experimental samples taken out for scientific research after the experiment cannot correctly reflect the intestinal environment. The state of digestion and absorption cannot guarantee the repeatability and accuracy of the experiment, which affects the conclusions of scientific research to a certain extent and cannot meet the requirements of current scientific research, thus restricting the development of related scientific research

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