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Filling liquid for stabilizing adsorption performance of adsorbent and application thereof

A technology of adsorption performance and adsorbent, which is applied in the direction of selective adsorption, other chemical processes, ion exchange, etc., can solve the problems of unstabilized adsorption performance of adsorbent, loss of adsorption performance, and decrease of adsorption efficiency, so as to achieve excellent effect and adsorption The effect of reducing the performance degradation rate and improving the adsorption efficiency

Active Publication Date: 2020-01-10
WUHAN RUIFA MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the filling liquid of low-density lipoprotein adsorption column has 0.04-0.08% (w / v) sodium citrate / citric acid solution (The LA-15AdsorptionColumns), however, the filling solution is a common buffer solution, which only plays the role of adjusting the pH value and storing at room temperature, and does not play a role in stabilizing the adsorption performance of the adsorbent during high-pressure steam sterilization
[0005] Therefore, in the prior art, there is no filling liquid that has a stabilizing effect on the adsorption performance in the high-pressure steam sterilization process. For the low-density lipoprotein adsorption column, the loss of its adsorption performance has caused a decline in adsorption efficiency and indirectly caused increase in production costs

Method used

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  • Filling liquid for stabilizing adsorption performance of adsorbent and application thereof
  • Filling liquid for stabilizing adsorption performance of adsorbent and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A filling solution for stabilizing the adsorption performance of the adsorbent, consisting of dextran 40 and phosphate buffer, wherein the mass-to-volume ratio of the amount of dextran 40 added to the phosphate buffer is 0.8g:100mL, the phosphate buffer The pH is 6.5.

[0020] The selected adsorbent is a low-density lipoprotein adsorbent whose ligand is dextran sulfate. After the adsorbent is soaked in the above-mentioned filling solution and sealed, it is sterilized by high-pressure steam. The sterilization conditions under pressure are 121°C and 30min. The adsorbent before and after sterilization was taken, washed with water and dried, and the low-density lipoprotein content was detected with a low-density lipoprotein cholesterol detection kit, and the adsorption performance was calculated.

Embodiment 2

[0022] A filling solution for stabilizing the adsorption performance of the adsorbent, consisting of dextran 70 and phosphate buffer, wherein the mass volume ratio of the amount of dextran 70 added to the phosphate buffer is 0.8g:100mL, the phosphate buffer The pH is 6.5.

[0023] The selected adsorbent is a low-density lipoprotein adsorbent whose ligand is dextran sulfate. After the adsorbent is soaked in the above-mentioned filling solution and sealed, it is sterilized by high-pressure steam. The sterilization conditions under pressure are 121°C and 30min. The adsorbent before and after sterilization was taken, washed with water and dried, and the low-density lipoprotein content was detected with a low-density lipoprotein cholesterol detection kit, and the adsorption performance was calculated.

Embodiment 3

[0025] A filling solution for stabilizing the adsorption performance of the adsorbent, consisting of dextran 20 and phosphate buffer, wherein the mass volume ratio of the amount of dextran 20 added to the phosphate buffer is 0.8g:100mL, the phosphate buffer The pH is 6.5.

[0026] The selected adsorbent is a low-density lipoprotein adsorbent whose ligand is dextran sulfate. After the adsorbent is soaked in the above-mentioned filling solution and sealed, it is sterilized by high-pressure steam. The sterilization conditions under pressure are 121°C and 30min. The adsorbent before and after sterilization was taken, washed with water and dried, and the low-density lipoprotein content was detected with a low-density lipoprotein cholesterol detection kit, and the adsorption performance was calculated.

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Abstract

The invention discloses a filling liquid for stabilizing adsorption performance of an adsorbent and application thereof. The filling liquid comprises a stabilizer and a base liquid, wherein the stabilizer is one or more of dextran and derivatives thereof, and the mass volume ratio of the stabilizer to the base liquid is 0.02-2.5g: 100 ml. The filling liquid provided by the invention can obviouslyreduce the reduction rate of the adsorption performance of the adsorbent after high-pressure steam sterilization, and is suitable for various adsorbents, especially low density lipoprotein adsorbentswith dextran sulfate as a ligand.

Description

technical field [0001] The invention belongs to the field of adsorbents, and in particular relates to a filling liquid for stabilizing the adsorption performance of adsorbents and an application thereof. Background technique [0002] Low-density lipoprotein (LDL) is a lipoprotein particle that carries cholesterol into peripheral tissue cells. When the oxidized low-density lipoprotein is excessive, the cholesterol it carries will accumulate on the artery wall, which will easily cause arteriosclerosis over time. Epidemiological evidence shows that elevated low-density lipoprotein is closely associated with an increased risk of myocardial infarction and death from vascular disease. [0003] As a new treatment method, low-density lipoprotein adsorption column can be used for the prevention and treatment of arteriosclerosis, especially for patients with hyperlipidemia such as familial hereditary hyperlipidemia. For the low-density lipoprotein adsorption column, the technical cor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/22B01D15/08
CPCB01J20/22B01J20/262B01D15/08B01J2220/4812
Inventor 张媛王业富张磊陈梦林
Owner WUHAN RUIFA MEDICAL DEVICES CO LTD
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