Application of loganin in preparation of medicine for preventing or treating renal insufficiency

A technology of loganside and renal function, applied in the field of medicine, can solve problems such as the research on the prevention and treatment of loganin for renal failure or clinical application, etc., and achieve the effect of comprehensive effect, improved state and remarkable effect.

Pending Publication Date: 2019-12-13
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] So far, there is no research on the prevention and treatment effect or clinical application of loganin on renal injury or renal failure

Method used

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  • Application of loganin in preparation of medicine for preventing or treating renal insufficiency
  • Application of loganin in preparation of medicine for preventing or treating renal insufficiency
  • Application of loganin in preparation of medicine for preventing or treating renal insufficiency

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Preparation Example 1 Loganinin Injection

[0040]

[0041] Preparation process: Mix the prescribed amount of ethanol and Tween-80 evenly, add loganin, stir to dissolve, add water for injection to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain.

Embodiment 2

[0042] Preparation Example 2 Loganinin Injection

[0043] Loganin 10g

[0044] Ethanol 3.3L

[0045] Add water for injection to 10L

[0046] Preparation process: add the prescribed amount of ethanol to loganin, stir to dissolve, add water for injection to 10L, stir evenly, add 0.5% activated carbon for needles, stir, and decarbonize to obtain the product.

Embodiment 3

[0047] Preparation Example 3 Loganinin Injection

[0048]

[0049] Preparation process: mix the prescribed amount of propylene glycol and ethanol evenly, add loganin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, add 0.5% activated carbon for needles, stir, and decarbonize to obtain .

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Abstract

The invention belongs to the field of medicines, and particularly relates to an application of loganin in preparation of a medicine for treating renal insufficiency. The test results show that the loganin has the good treatment effect on acute and chronic renal injury or renal failure, the treatment effect is comprehensive, the renal injury symptom can be fundamentally relieved, and the loganin can be prepared into various dosage forms such as oral preparations or injection preparations and has the wide development prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of loganin in the preparation of drugs for preventing or treating renal insufficiency. Background technique [0002] Kidney injury accounts for about 65% of all genitourinary tract injuries. Causes include sudden injury, penetrating injury, and iatrogenic injury. With the rapid development of industry and the continuous acceleration of the research and development process of new drugs, kidney damage caused by chemical substances, drugs and other factors is increasing day by day. In addition, some diseases such as diabetes and high blood pressure can also damage the kidneys and cause kidney damage. Therefore, it is imminent to develop a drug that can prevent and treat the above-mentioned renal injury. [0003] Epidemiological survey found that in developed countries in Europe and America, through clinical observation of diabetic patients, as many as 20% to 40% of pat...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P13/12
CPCA61K31/352A61P13/12
Inventor 张贵民李光艳王升兰
Owner LUNAN PHARMA GROUP CORPORATION
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