A group of brain proteins whose expressions are regulated by drug dl-PHPB
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A histone, dl-phpb technology, applied in the medical field, can solve the problem of inability to prepare injection dosage forms
Pending Publication Date: 2019-12-06
LUDONG UNIVERSITY
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However, dl-NBP is a high-boiling point oil that cannot be prepared into an effective injection form, and is not suitable for severe patients who cannot be taken orally. The lactone ring-opened product dl-PHPB has good water solubility and can be made into various dosage forms. And dl-PHPB is a solid crystal, which can be purified after recrystallization, easy to prepare in large quantities, and convenient to store
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[0007] The present invention will be described in detail below in combination with specific embodiments.
[0008] 1. Experimental animals
[0009] Male B6C3-Tg (APPswe, PSEN1dE9) 85Dbo / J (APP / PS1) transgenic mice, wild-type (WT) mice of the same age, were purchased from Jackson Lab in the United States, and were kept in the model animal center of Nanjing University. Breeding, Breeding and genotyping. When the mice are bred to 9 months old, they are airlifted to the experimental center in clean packaging, and placed in a cage for every 3-5 mice. The room temperature is kept at 24±1°C and the humidity is 50-60%. :00 light, 20:00-8:00 the next day closed care, free to eat and drink.
[0010] 2. Experimental method
[0011] Animals were randomly divided into 5 groups, 8-10 in each group, respectively control group (WT mice), model group (APP / PS1 mice) and dl-PHPB treatment group (APP / PS1 mice), memantine treatment group group (APP / PS1 mice), donepezil treatment group (APP / PS1 ...
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Abstract
The invention discloses a group of brain proteins whose expressions are regulated by drug dl-PHPB. The dl-PHPB processing can obviously change the expressions of the following group of proteins in thecerebral cortex and hippocampus of an AD model mouse: histidine triad nucleotide binding protein 1, fatty acid binding protein, pyruvate dehydrogenase E1 component subunitalpha(PDHE1alpha), peroxiredoxin-6, cathepsin B, isocitrate dehydrogenase, dihydropyrimidinase-related protein 2(DRP-2), dihydrolipoamide succinyltransferase, dihydropyrimidinase related protein 5(DRP 5), peptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Pin 1), voltage dependent anion selective channel protein 1(VDAC1), carbonic anhydrase 2, malate dehydrogenase, alpha-enolase and cofilin 2.
Description
technical field [0001] The invention belongs to the technical field of medicine, and relates to the effect of drug dl-PHPB on the protein expression of cerebral cortex and hippocampus with cognitive function damage. Background technique [0002] Alzheimer's disease (AD), commonly known as senile dementia, is an age-related neurodegenerative disease, its pathogenesis is still unclear, and there are many hypotheses: neurotransmitter defects, inflammation, freedom basal damage, amyloid neurotoxicity, hormone deficiency, apoptosis, etc. In addition, environmental factors such as culture, upbringing, smoking, traumatic brain injury, heavy metal exposure history, early pregnancy and viral infection can increase the risk of AD. At present, the treatment of AD is still based on drugs, including acetylcholine, cholinesterase inhibitors and acetylcholine-releasing drugs, anti-inflammatory drugs, estrogen drugs, antioxidant drugs, and brain metabolism activators. These drugs can only...
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