Gel tube preparation device and micron-sized gel tube prepared by same and used for glaucoma drainage

A preparation device and micron-scale technology, applied in ophthalmic surgery, coating, etc., can solve the problems of complex preparation process, easy to cause infection, uneven thickness, etc., achieve simple preparation process, easy process control, suitable for large-scale industrialization The effect of rapid production

Active Publication Date: 2019-12-03
杭州瑞睫医疗科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current glaucoma drainage valve device has a large volume and heavy trauma. It is easy to cause infection after surgery and leave scar tissue. In severe cases, a second surgery may even be required.
In addition to the drainage valve device, the metal drainage nail is also a more commonly used method recently. However, the metal drainage nail is hard and has a strong foreign body sensation, which makes patients feel poor in use.
[0004] In recent years, there have also been some treatment plans that use micron-sized hoses as glaucoma drainage tubes to export aqueous humor into the trabecular meshwork to reduce intraocular pressure. However, the existing micron-sized hoses are all prepared by the method of solution adsorption and coagulation. For example, CN107811752A discloses a scheme in which a tubular formwork is added into a chitosan solution, and then a micron-scale hose is prepared by the method of chitosan adsorption and solidification, but there is an obvious problem in the hoses made by this type of scheme. The surface of the hose is uneven and the thickness is not uniform. At the same time, the preparation process of this kind of scheme is complicated, time-consuming and labor-intensive, and the economy is poor
[0005] Therefore, research and development of a micron-scale gel tube for glaucoma drainage and its preparation device has the advantages of simple preparation process, easy-to-control process, and smooth surface and uniform thickness, so as to ease the pain caused by the soft gel tube prepared by the existing coating coagulation method. The problem of complex pipe preparation process, uneven surface and uneven thickness has become very necessary and urgent

Method used

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  • Gel tube preparation device and micron-sized gel tube prepared by same and used for glaucoma drainage

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Effect test

preparation example Construction

[0075] According to one aspect of the present invention, a kind of preparation method of above-mentioned gel tube, described method comprises the following steps:

[0076] The wire 2 enters the gel cavity 1 through the wire inlet 11 through the wire drawing device 3, and adheres the gel solution in the gel inner cavity 13, and then passes through the center of the wire outlet 12, so that the surface of the wire 2 The gel solution is adhered, and then the metal wire 2 with the gel solution adhered on the surface is solidified, and finally the metal wire 2 is drawn out to obtain a gel tube.

[0077] The preparation method of the gel tube provided by the present invention is that the metal wire 2 enters the gel chamber 1 through the wire drawing device 3 through the wire inlet 11, and adheres the polymer hydrogel material in the gel inner chamber 13 The gel solution passes through the center of the wire outlet 12 subsequently, so that the surface of the metal wire 2 is adhered to...

Embodiment 1

[0099] Such as figure 1 As shown, a gel tube preparation device, the preparation device includes a gel cavity 1, a wire 2 and a wire drawing device 3;

[0100] The gel cavity 1 is mainly composed of a gel inner cavity 13 and a thermal insulation outer cavity 14 that are coated inside and outside;

[0101] The gel chamber 1 is provided with a wire inlet 11 and a wire outlet 12, the wire 2 enters the gel chamber 1 from the wire inlet 11 through the wire drawing device 3, and adheres in the gel inner chamber 13 After the gel is passed through the center of the wire outlet 12, the outer layer of the wire 2 coated with gel is obtained, and the wire 2 is drawn out after curing and forming to prepare a gel tube;

[0102] The ratio of the inner diameter of the wire outlet 12 to the diameter of the wire 2 is 4˜2:1.

[0103] The gel tube preparation device provided in this embodiment includes a gel cavity 1, a metal wire 2 and a wire drawing device 3; the gel cavity 1 is mainly compos...

Embodiment 2

[0113] A micron gel tube for glaucoma drainage, the gel tube is made by the gel tube preparation device of the above-mentioned embodiment 1;

[0114] Wherein, the inner diameter of the metal wire outlet 12 in the preparation device is 400 μm, and the diameter of the metal wire 2 is 100 μm.

[0115] The specific preparation steps of the above-mentioned micron gel tube for glaucoma drainage are as follows:

[0116] (1) Dissolve 20g of gelatin solution in 40ml of water and heat to 50°C to dissolve overnight. Add the dissolved gelatin solution into the gel chamber 1 after ultrasonic defoaming;

[0117] (2), before the preparation starts, hot water enters from the insulation solution inlet 141, and the temperature of the gelatin solution is kept at about 50°C through the insulation outer cavity 14, so as not to solidify during the preparation of the gel tube. Liquid outlet 142 flows out to complete the whole hot water cycle;

[0118] (3), in the forming stage of the gel tube, th...

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Abstract

The invention provides a gel tube preparation device and a micron-sized gel tube prepared by the gel tube preparation device and used for glaucoma drainage, and relates to the technical field of medical new materials. The gel tube preparation device comprises a gel cavity, a metal wire and a wire drawing device; the gel cavity is mainly composed of a gel inner cavity and a heat preservation outercavity which are arranged in an inside-outside wrapping mode. Meanwhile, the gel cavity is provided with a metal wire inlet and a metal wire outlet; the metal wire enters the gel cavity from the metalwire inlet through the wire drawing device, penetrates out of the center of the metal wire outlet after being adhered with gel in the gel inner cavity to obtain a metal wire coated with the gel on the outer layer, and is drawn out after being cured and formed to prepare the gel tube; in addition, the ratio of the inner diameter of the metal wire outlet to the diameter of the metal wire is 4-2: 1.Compared with a hose prepared through an existing solution adsorption solidification method, the micron-sized gel tube for glaucoma drainage and prepared through the preparation device has the advantages of being smooth in surface and uniform in thickness.

Description

technical field [0001] The invention relates to the technical field of new medical materials, in particular to a gel tube preparation device and the prepared micron gel tube for glaucoma drainage. Background technique [0002] Glaucoma is one of the three major blindness diseases of human beings, with an incidence rate of 1% in the total population and 2% after the age of 45. Glaucoma causes abnormal high pressure in the eye, which can lead to damage to the optic nerve. As the patient grows older, the intraocular pressure will continue to increase causing continuous damage to the optic nerve. The current main treatment methods focus on lowering the intraocular pressure, keeping the intraocular pressure within the normal range, and ensuring that the patient can maintain a certain vision. [0003] Traditional treatments include the use of medications to reduce pressure inside the eye. However, drug treatment can cause many adverse reactions and cannot accurately control int...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C41/30A61F9/007
CPCA61F9/00781B29C41/30
Inventor 谭睿哲李锐聪邹鹏梁丽金陈琦
Owner 杭州瑞睫医疗科技有限公司
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