Online analysis system for spatiotemporal expression patterns of human brain genes and method thereof

Abstract

The invention discloses an online analysis system for spatiotemporal expression patterns of human brain genes and a method thereof. A reference database platform includes a human brain gene spatiotemporal expression normal pattern, a thousand-person genome database, an Ensembl database and a dbSNP database; the human brain gene spatiotemporal expression normal pattern is used for, based on a constructed spatiotemporal framework of each brain region and each developmental stage, forming matrix expression patterns of genes or gene modules between each brain region and each developmental stage aswell as enrichment matrix expression patterns between the gene modules and cell types; a data analysis module is arranged in a server; a gene set data input module and a graphic visualization moduleare arranged in a client, the server is used for analyzing the spatiotemporal patterns of input gene set data, and the gene analysis results are graphically presented through the graphical visualization module. By using the online analysis system for the spatiotemporal expression patterns of the human brain genes and the method thereof, user-friendly and easy-to-understand visualization results are generated at the client to help to clarify the complex spatiotemporal expression patterns of the genes and reflect the relationship between the analyzed genes.

Description

technical field [0001] The invention relates to the technical field of human brain modeling, and in particular to an online analysis system and method for human brain gene spatiotemporal expression patterns. Background technique [0002] The development of the human brain occurs over a long period of time, with extremely complex and precise regulation. From embryonic stage to adulthood and various stages of aging, the human brain undergoes long-term development, refinement and maturation, undergoing molecular, connection and structural changes. Provide insights into susceptibility to certain brain disorders such as neurodegenerative and psychiatric disorders by studying gene expression patterns in regions of normal brain function, developmental stages, and different neural cell types. [0003] At present, there are some human brain gene expression databases, but not all databases or tools support the analysis of different types of genetic results. For example, Allen Brain A...

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Problems solved by technology

[0004] In order to solve the problem that existing databases or tools are difficult to analyze different types of genetic results, and at the same time it is impossible to analyze the co-expression relationship between genes, the present invention provides an online analysis system for human brain gene spatiotemporal expression patterns and its This method provides an important research basis for obtaining the temporal and spatial expression patterns of disease susceptibility genes in the brain

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