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Grafting product and preparation method thereof

A product and solution technology, applied in the field of grafted products and their preparation, can solve the problems of limited application fields, inconvenient preparation of grafted products, etc., and achieve the effects of simple molecular formula, good physical and chemical properties and mechanical properties, and wide application.

Pending Publication Date: 2019-11-05
JIANGSU TRAUTEC MEDICAL TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These two raw materials are not convenient for the preparation of grafted products, and the application fields are limited

Method used

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  • Grafting product and preparation method thereof
  • Grafting product and preparation method thereof
  • Grafting product and preparation method thereof

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preparation example Construction

[0033] According to the preparation method 100 of the grafted product of the second aspect embodiment of the present invention, such as figure 1 As shown, the method mainly includes the following steps:

[0034] S1, dissolving the recombinant collagen in PBS solution;

[0035] S2, adding methacrylic anhydride to the PBS solution in which the recombinant collagen is dissolved to form a reaction solution;

[0036] S3. Pour PBS solution into the reaction solution to dilute the reaction solution and terminate the reaction;

[0037] S4. Dialyzing the diluted reaction solution, centrifuging the dialyzed solution, and collecting the supernatant;

[0038] S5. Freeze-drying the supernatant to obtain a grafted product.

[0039] Specifically, the grafted product is mainly obtained by the following reaction formula:

[0040]

[0041] In one embodiment of the present invention, in step S1, recombinant collagen is obtained by transferring a recombinant vector capable of translating a...

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Abstract

The invention provides a grafting product and a preparation method thereof. The molecular formula of the grafting product is as follows (please see the specification of the formula). According to thegrafting product of the embodiment, the molecular formula is simple, the physical and chemical properties and the mechanical properties are good, and the application is wide.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a graft product and a preparation method thereof. Background technique [0002] A part of the collagen raw material used in the prior art is derived from natural materials such as animals, and the other part is derived from synthetic materials. The natural material is collagen obtained by enzymatically degrading tissue animals and organs, which has poor immunogenicity and poor mechanical strength, and The price cost is higher. Synthetic materials mainly refer to Pluronic and polyethylene glycol (PEG), etc. Although synthetic materials have good prospects in improving mechanical properties, printability, cross-linking, etc., compared with natural materials, they are more effective in promoting cell Poor performance in terms of attachment and proliferation. These two raw materials are inconvenient to prepare grafted products, and their application fields are limited. Contents of th...

Claims

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Application Information

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IPC IPC(8): C07K14/78C07K1/113C07K1/34
CPCC07K14/78
Inventor 杨自言
Owner JIANGSU TRAUTEC MEDICAL TECH CO LTD
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