Phosphorus-containing molecular carrier PPS based target polypeptide liquid-phase synthesis method

Abstract

The invention relates to a phosphorus-containing molecular carrier PPS based target polypeptide liquid-phase synthesis method. By adoption of phosphorus-containing molecular carrier PPS for substituting a resin carrier in solid-phase polypeptide synthesis, polypeptide separation and purification are facilitated, damage after shearing is avoided, and easiness in recycling is achieved. The polypeptide synthesis method integrates advantages of liquid-phase and solid-phase synthesis methods, simplicity, convenience, quickness, saving and high efficiency in large-scale synthesis of polypeptides andderivatives area realized, and the phosphorus-containing molecular carrier can be recovered and reused directly, so that raw material waste can be reduced, waste pollution is reduced, cost saving isrealized, environmental protection is benefited, and an evident practical application value in organic synthesis and polypeptide chemistry is achieved.

Description

Technical field [0001] The invention belongs to the field of organic synthesis and polypeptide chemistry, and relates to a method for liquid phase synthesis of target polypeptides based on a phosphorus-containing small molecule carrier PSS, in particular to phosphoryloxybenzyl alcohols or phosphoryloxybenzaldehyde (or ketone) The oxime derivatives etc. are resin-free peptide synthesis methods with phosphorus-containing small molecule carriers. Background technique [0002] Polypeptides and proteins play a central role in many biological and physiological processes in organisms. They act as hormones, neurotransmitters in cell-to-cell communication, antibodies that protect organisms from foreign invasion, and participate in the passage of various substances through biological membranes. Transportation. Understanding the mechanisms and principles that control the structure and functional properties of biologically active proteins at the molecular level is a major goal of medicinal ...

AI Technical Summary

Problems solved by technology

[0011] In order to avoid the deficiencies of the prior art, the present invention proposes a liquid-phase synthesis method for the target polypeptide based on the phosphorus-containing small molecule carrier PSS, which solves the problem that the liquid-phase reaction of the current polypeptide chemical synthesis method is relatively complicated, and the separation steps are many and time-consuming. Long cycle, small purification scale, high production cost, while solid phase reaction has small production scale, expensive raw materials, large waste, many resin wastes and serious environmental pollution problems

Images