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A kind of medical polyurethane material containing lactone group and its preparation method and medical catheter

A polyurethane material, medical catheter technology, applied in the direction of medical science, surgery, etc., can solve the problems of reducing the inner diameter of the catheter, reducing the input flow rate of the liquid medicine, and not having thermoplastic processability, etc. The effect of stiffness reduction

Active Publication Date: 2020-07-28
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this type of catheter is that the inner diameter of the catheter is significantly reduced after absorbing water, resulting in a decrease in the input flow rate of the liquid medicine, which is not conducive to the rapid treatment of diseases, and the melt extrusion process of polyurethane materials is extremely sensitive to water, and the introduction of hydrophilic groups , increasing the difficulty of the drying process of polyurethane materials
The U.S. patent with the publication number US5281677 and the Chinese patent with the authorization number ZL201310302169.8 respectively propose methods for preparing medical interventional catheters using polyurethane blends. They adopt different technical routes. After the prepared blends are processed into catheters, When placed at room temperature, it has rigidity that is conducive to puncture. After entering the human body, the elastic modulus can be reduced by 70-88%, and there will be no water swelling phenomenon, thereby significantly reducing the degree of mechanical stimulation of the catheter to the tissue. However, this Method does not soften enough in vivo relative to hydrophilic polyurethane materials
Publication number is US 4156067 U.S. patent adopts six-carbon saccharyl lactone to prepare alkali water-soluble polyurethane material, but the six-carbon saccharic acid lactone in this material contains more than two hydroxyl groups, and the polyurethane material of gained has crosslinking Structural, not thermoplastically processable

Method used

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  • A kind of medical polyurethane material containing lactone group and its preparation method and medical catheter

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preparation example Construction

[0032] The present invention provides a kind of preparation method of medical polyurethane material described in above-mentioned technical scheme, comprises the following steps:

[0033]Mix 4,4`-diphenylmethane diisocyanate, butanediol, polytetrahydrofuran, substances containing butyrolactone groups and lubricants uniformly, then extrude and granulate to obtain medical polyurethane containing butyrolactone groups Material;

[0034] In the present invention, the lubricant is selected from ethylene bisstearamide.

[0035] In the present invention, a twin-screw extruder with an aspect ratio of 44 / 1 is preferably used for extrusion granulation. In the present invention, the extrusion granulation temperature is preferably 200-220°C, more preferably 205-215°C; in a specific embodiment, the extrusion granulation temperature is 210°C.

[0036] The present invention provides a medical catheter, which is produced by extruding the medical polyurethane material described in the above te...

Embodiment 1

[0042] Slowly add 0.5 mol (51.0 g) of 3-hydroxybutyrolactone to 0.5 mol (125.1 g) of 4,4'-diphenylmethane diisocyanate (MDI) at 80°C, and react for 2 hours. 0.5 mol (45.5 g) of 3-amino-1,2-propanediol (APD) was slowly added dropwise thereto, and the reaction was continued for 2 h to obtain 0.5 mol (221.6 g) of lactone polyol. In a reaction kettle at 100°C, 10mol (2502.4g) of MDI was reacted with 2mol (2000g) of polytetrahydrofuran (PTMO) with a molecular weight of 1000g / mol for 20min, and then 7.5mol (675.5g) was added thereto under vigorous stirring. The mixed solution of butanediol and the lactone polyol of 0.5mol (221.6g), and 16.2g ethylene bisstearamide, pass through the twin-screw extruder that length-diameter ratio is 44 / 1 after fast mixing uniformly at 210 Extrusion granulation at ℃. A medical polyurethane material with a lactone content of 9.2 mmol / 100 g and a hard segment content of 57.5 wt % was obtained. Press the polyurethane material into a sheet with a thickne...

Embodiment 2

[0045] Slowly add 0.7 mol (71.4 g) of 3-hydroxybutyrolactone to 0.7 mol (175.1 g) of 4,4'-diphenylmethane diisocyanate (MDI) at 80°C, and react for 2 hours. 0.7 mol (63.7 g) of 3-amino-1,2-propanediol (APD) was slowly added dropwise thereto, and the reaction was continued for 2 h to obtain 1.0 mol (310.2 g) of lactone polyol. In a reaction kettle at 100°C, 10mol (2502.4g) of MDI was reacted with 2.5mol (2500g) of polytetrahydrofuran (PTMO) with a molecular weight of 1000g / mol for 20 minutes, and then 6.8mol (612.8g) was added to it under vigorous stirring. ) of butanediol and 0.7mol (310.2g) of the lactone polyol mixed solution, and 16.2g ethylene bisstearamide, after rapid mixing, the length-to-diameter ratio is 44 / 1 through the twin-screw extruder Extruded and granulated at 210° C., a medical polyurethane material with a lactone content of 11.8 mmol / 100 g and a hard segment content of 52.4 wt % was obtained. Press the polyurethane material into a sheet with a thickness of 0...

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Abstract

The invention provides a medical polyurethane material containing a lactone group and a medical catheter prepared therefrom. The medical polyurethane material is prepared by polycondensation of the following raw materials: 4,4`-diphenylmethane diisocyanate, butanediol, polytetrahydrofuran, and substances containing butyrolactone groups; among the substances containing butyrolactone groups It contains at least two hydroxyl groups, and the molar mass concentration of butyrolactone groups in the medical polyurethane material is 5-20mmol / 100g. In the dry state of the medical polyurethane material provided by the invention, the lactone group is in a closed-loop state, which can maintain the hydrophobicity of the polyurethane and does not affect the extrusion molding of the polyurethane material. In the aqueous phase environment or in the body, the lactone group will The hydrolysis ring-opening reaction increases the hydrophilicity of the polyurethane material and significantly reduces the elastic modulus of the polyurethane material. The medical catheter prepared by it has high rigidity in vitro, and its softness increases significantly after entering the human blood vessel.

Description

technical field [0001] The invention belongs to the technical field of biomedical polyurethane materials, and in particular relates to a medical polyurethane material containing lactone groups, a preparation method thereof and a medical catheter. Background technique [0002] Medical catheters refer to high-end precision medical devices used to transport gases, liquids and solids into the body during disease treatment. After decades of development, medical interventional catheters play a role in the treatment of various diseases in the medical field today. more and more important. In addition to having good biocompatibility, raw materials for medical catheters must also have special mechanical properties. [0003] Taking intravenous indwelling needle catheter as an example, in order to reduce the intensity of mechanical stimulation of the catheter tip to human tissue and reduce the incidence of complications such as inflammation, pain, thrombus, and drug penetration at the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/66C08G18/48C08G18/32C08L75/08A61L31/06A61L31/14
CPCA61L31/06A61L31/14C08G18/3221C08G18/4854C08G18/6674C08L75/08C08L2203/02C08L2203/18
Inventor 杨华伟栾世方殷敬华石恒冲宋凌杰
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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