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Pt@PCN-224 photocatalyst for preparing artemisinin from dihydroarteannuic acid and preparation method of Pt@PCN-224 photocatalyst

A technology of dihydroartemisinic acid and photocatalyst, which is applied in the direction of organic compound/hydride/coordination complex catalyst, chemical instrument and method, physical/chemical process catalyst, etc., which can solve the problem of high cost, yield and conversion rate Low-level problems, to achieve high porosity, reduce production costs, and good application prospects

Active Publication Date: 2019-10-15
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of metal nanoparticles, porphyrins and their derivatives as photocatalysts still has the problem of high cost or low yield and conversion.

Method used

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  • Pt@PCN-224 photocatalyst for preparing artemisinin from dihydroarteannuic acid and preparation method of Pt@PCN-224 photocatalyst
  • Pt@PCN-224 photocatalyst for preparing artemisinin from dihydroarteannuic acid and preparation method of Pt@PCN-224 photocatalyst
  • Pt@PCN-224 photocatalyst for preparing artemisinin from dihydroarteannuic acid and preparation method of Pt@PCN-224 photocatalyst

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 120mg Zr 6 The metal clusters are dissolved in 5 ml of a mixed solution A of N,N-dimethylacetamide and acetic acid. The volume ratio of N,N-dimethylacetamide and acetic acid in solution A is any one of 0:5 to 4:1. 60 mg of tetracarboxylic phenylporphyrin was dissolved in 2.5 ml of N,N-dimethylacetamide to obtain a mixed solution B. Pt nanoparticles (1mg, 3mg, 5mg) were dissolved in 2.5ml of N, N-dimethylacetamide to obtain mixed solution C. The three are completely mixed under stirring conditions with a magnetron rotating speed of 900 revolutions per minute, stirring at 25 degrees Celsius, the stirring time is controlled between 0.5-24 hours. The preliminary product was collected by centrifugation, washed with N, N-dimethylacetamide three times, washed once with acetone, and dried to obtain pure phases Pt@PCN-224-1, Pt@PCN-224-3, Pt@PCN-224-5. For the final product.

Embodiment 2

[0035] 120mg Zr 6 The metal clusters were dissolved in 5 ml of a mixed solution A of N,N-dimethylacetamide and acetic acid, and the volume ratio of N,N-dimethylacetamide and acetic acid in solution A was 2:3. Dissolve 60 mg of TCPP-Zn (or TCPP-Co, TCPP-Ni) in 2.5 ml of N, N-dimethylacetamide to obtain a mixed solution B. Dissolve 1 mg of Pt nanoparticles in 2.5 ml of N, N-dimethylacetamide to obtain a mixed solution C. The three are completely mixed under stirring conditions with a magneto rotating speed of 900 revolutions per minute, and stirring at 25 degrees Celsius for 9 hours. The preliminary product was collected by centrifugal separation, washed with N, N-dimethylacetamide three times, washed once with acetone, and dried to obtain pure phases Pt@PCN-224-Zn, Pt@PCN-224-Co, Pt@PCN-224-Ni For the final product.

Embodiment 3

[0037] Dihydroartemisinic acid (25mg, 0.106mmol), Pt@PCN-224 or its derivatives obtained in Example 1 and Example 2 (0.002mmol, based on porphyrin), trifluoroacetic acid (8μL), dispersed in 5ml A mixed solution is obtained in methyl chloride. The mixed solution was slowly bubbling with oxygen for 3 hours under LED light illumination. Remove the dichloromethane contained in the reactant and pass 1 H NMR further proved the conversion rate of dihydroartemisinic acid. Finally, the conversion rate of Pt@PCN-224-1 was 98%, and the yield rate was 45%. The conversion rate of Pt@PCN-224-3 was 99%, and the yield was 50%. The standardization rate of Pt@PCN-224-5 is 99%, and the yield is 51%. The conversion rate of Pt@PCN-224-Zn is 99%, the yield is 54%, the conversion rate of Pt@PCN-224-Co is 99%, the yield is 53%, and the conversion rate of Pt@PCN-224-Ni is 99%. , The yield is 52%.

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Abstract

The invention provides Pt@PCN-224 and derivatives thereof which are used as a photocatalyst for preparing artemisinin from dihydroarteannuic acid, also provides a preparation method of Pt@PCN-224 andthe derivatives, and belongs to the field of preparation and application of MOF (metal-organic framework) materials. By means of the advantages of large specific surface area and high porosity of MOFs, the MOFs are taken as carriers, porphyrin and Pt nano-particles are synergistically used as the photocatalyst, high activity and high selectivity of the catalyst are guaranteed by interaction, and the catalytic action of the catalyst is improved; a biosynthetic precursor (arteannuic acid) is adopted for photochemical semi-synthesis, so that cost of extraction or complete synthesis of artemisininis reduced; the preparation method of the Pt@PCN-224 photocatalyst for preparing artemisinin from dihydroarteannuic acid is simple and high in operability.

Description

Technical field [0001] The invention belongs to the field of metal organic framework material preparation and its application, and in particular relates to a Pt@PCN-224 photocatalyst for preparing artemisinin from dihydroartemisinic acid and a preparation method thereof. Background technique [0002] Metal Organic Frameworks (MOFs), referred to as MOFs, are porous materials with a periodic network structure formed by metal ions or metal clusters and organic ligands through coordination bonds. It has the advantages of high porosity, large specific surface area, designable and controllable framework structure, etc. Based on the above advantages, MOFs have gradually been paid attention to by researchers. In the past ten years, MOFs have shown great application prospects in fluorescence, catalysis, gas adsorption and separation, proton conductors, and drug transportation. [0003] Malaria is a worldwide epidemic with serious harm. About 300 million people are infected with malaria eve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J31/28C07D493/20
CPCB01J31/28C07D493/20B01J2531/48B01J2531/26B01J2531/845B01J2531/847B01J2531/025B01J2231/766B01J35/393B01J35/23B01J35/39
Inventor 张亮亮刘振国陈妍慧李佳佩
Owner NORTHWESTERN POLYTECHNICAL UNIV
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