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Polyphenol compound, preparation method thereof and application thereof in electronic cigarettes

A technology of polyphenolic compounds and extracts, applied in the field of polyphenolic compounds and their preparation, can solve the problems of less research on polyphenolic compounds, and achieve the effects of easy popularization and application, good antibacterial activity, and increased shelf life

Inactive Publication Date: 2019-09-20
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few studies on the polyphenolic compounds contained in it. For this reason, the study of polyphenolic compounds and their activities in bark willow bark can provide new ideas for the utilization of bark willow bark.
Compound of the present invention has not been reported so far

Method used

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  • Polyphenol compound, preparation method thereof and application thereof in electronic cigarettes
  • Polyphenol compound, preparation method thereof and application thereof in electronic cigarettes
  • Polyphenol compound, preparation method thereof and application thereof in electronic cigarettes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation method of polyphenol compound shown in formula (I), comprises the steps:

[0046] Step (1), extraction of extract: crush the dried willow bark into 30-50 meshes, use 70% ethanol aqueous solution as the extraction solvent, extract at room temperature, filter the extract, and concentrate the filtrate under reduced pressure to obtain extract;

[0047] Step (2), one-time silica gel column chromatography: apply the extract obtained in step (1) to silica gel column chromatography, and perform gradient elution with a mixed organic solvent of petroleum ether and acetone, and the volume ratio is 10:1, 10:3 in sequence , 10:5, 10:6, 10:7, 10:9 and 10:10, after each gradient eluted to the TLC spot plate without spots, replace the next gradient elution; collect the gradient elution of each gradient and Concentrated and monitored by TLC, the same fractions were combined to obtain seven fractions A1-A7;

[0048]Step (3), secondary silica gel column chromatography: w...

Embodiment 2

[0051] The preparation method of polyphenol compound shown in formula (I), comprises the steps:

[0052] Step (1), extraction of extract: crush the dried willow bark into 30-50 meshes, use 95% ethanol aqueous solution as the extraction solvent, extract at room temperature, filter the extract, and concentrate the filtrate under reduced pressure to obtain extract;

[0053] Step (2), one-time silica gel column chromatography: apply the extract obtained in step (1) to silica gel column chromatography, and perform gradient elution with a mixed organic solvent of petroleum ether and acetone, and the volume ratio is 10:1, 10:3 in sequence , 10:5, 10:6, 10:7, 10:9, and 10:10, each gradient eluted to the TLC plate without spots, then replaced the next gradient elution; collected the gradient elution of each gradient and Concentrated and monitored by TLC, the same fractions were combined to obtain seven fractions A1-A7;

[0054] Step (3), secondary silica gel column chromatography: wi...

Embodiment 3

[0062] The preparation method of polyphenol compound shown in formula (I), comprises the steps:

[0063] Step (1), extracting the extract: crushing the dried willow bark into 30-50 meshes, using 80% ethanol aqueous solution as the extraction solvent, extracting at room temperature, filtering the extract, and concentrating the filtrate under reduced pressure to obtain extract;

[0064] Step (2), one-time silica gel column chromatography: apply the extract obtained in step (1) to silica gel column chromatography, and perform gradient elution with a mixed organic solvent of petroleum ether and acetone, and the volume ratio is 10:1, 10:3 in sequence , 10:5, 10:6, 10:7, 10:9, and 10:10, each gradient eluted to the TLC plate without spots, then replaced the next gradient elution; collected the gradient elution of each gradient and Concentrated and monitored by TLC, the same fractions were combined to obtain seven fractions A1-A7;

[0065] Step (3), secondary silica gel column chro...

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Abstract

The invention relates to a polyphenol compound, a preparation method thereof and application in electronic cigarettes, belonging to the technical field of phytochemistry. The structural formula of the compound is shown in formula (I). The polyphenol compound is separated from Periploca sepium Bunge bark for the first time, and is determined to be a polyphenol compound through nuclear magnetic resonance and mass spectrometry, and the specific structure of the polyphenol compound is characterized. The compound shows good antibacterial activity and antifungal activity. Meanwhile, the compound is used in electronic cigarette tobacco juice, not only has a good antibacterial effect, can increase the shelf life of the electronic cigarette tobacco juice, but also can reduce the sweet and greasy feeling in the smoking process, and is easy to popularize and apply.

Description

technical field [0001] The invention belongs to the technical field of phytochemistry, and in particular relates to a polyphenol compound, a preparation method thereof, and an application in electronic cigarettes. Background technique [0002] Polyphenols refer to a group of chemical substances in plants, named for their multiple phenolic groups. There are many types of polyphenols with different structures, and their bioavailability, antioxidant properties and effects on the human body are also different. Polyphenolic compounds can be roughly divided into flavonoids, stilbenes, phenolic acids and lignans according to their structures. [0003] Due to their good antioxidant activity, polyphenolic compounds can work together with other antioxidants such as vitamin E and carotene to exert antioxidant effects in the body, and remove substances harmful to human health-free radicals. Therefore, it has attracted more and more attention from the scientific community. [0004] Pe...

Claims

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Application Information

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IPC IPC(8): C07C47/575C07C45/78C07C45/79A01N35/04A01P1/00A01P3/00A24B15/30A24B15/16
CPCA01N35/04A24B15/301A24B15/167C07C47/575
Inventor 赵伟洪鎏朱东来巩效伟张霞韩熠李寿波李廷华陈永宽
Owner CHINA TOBACCO YUNNAN IND
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