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Application of carnosol as inhibitor of inflammasomes

A technology of carnosol and inflammasome, applied in the field of drug screening

Inactive Publication Date: 2019-09-13
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no clinical application of relevant targeted drugs in the treatment of acquired inflammatory diseases and autoimmune diseases. Therefore, the development of inflammasome inhibitors to inhibit the abnormal activation of inflammasomes will be beneficial to the treatment of the above diseases and provide new avenues for treatment

Method used

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  • Application of carnosol as inhibitor of inflammasomes
  • Application of carnosol as inhibitor of inflammasomes
  • Application of carnosol as inhibitor of inflammasomes

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Embodiment Construction

[0030] In order to make the purpose, technical solution and advantages of the application clearer, the embodiments of the application will be described in detail below in conjunction with the accompanying drawings. It should be noted that, in the case of no conflict, the embodiments in the present application and the features in the embodiments can be combined arbitrarily with each other.

[0031] drug:

[0032] Carnosol and MCC950 were purchased from TargetMol; LPS was purchased from Sigma, USA.

[0033] Reagents and materials:

[0034] DMEM medium, fetal bovine serum (U.S. HyClone company); Opti-MEM serum-free medium (U.S. Gibco company); trypsin, double antibody (penicillin-streptomycin solution) (Maichen Technology Beijing Co., Ltd.); adenosine triphosphate ( ATP), nigericin (Nigericin), lipopolysaccharide (LPS), dimethylsulfoxide (DMSO) (Sigma Aldrich, USA); NLRP3, ASC, Caspase-1, pro-Caspase-1, pro-IL1β, GAPDH Antibody (U.S. Cell Signaling Technology Company); CCK-8 k...

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Abstract

The invention discloses application of carnosol as an inhibitor of inflammasomes. The carnosol has inhibitory effects on various inflammasomes, is a broad-spectrum inhibitor of inflammasomes, and is used for developing drugs for treating acquired inflammatory diseases and autoimmune diseases.

Description

technical field [0001] This application relates to the field of drug screening, especially but not limited to the use of carnosol as an inhibitor of inflammasomes. Background technique [0002] The inflammasome is a large multiprotein complex in cells composed of receptor protein, apoptosis-associated speck-like protein (ASC) and caspase-specific protease 1 The inflammasome is composed of pro-caspase-1, which recognizes pathogenic microorganisms and endogenous danger signals through pattern recognition receptors (PRR), that is, pathogen-associated molecular patterns (pathogen associated molecular patterns, PAMPs) and danger-related molecules Damage associated molecular pattern (DAMP), recruits and activates caspase-1, cleaves IL-1β and IL-18 precursors, produces corresponding mature cytokines, thereby promoting cell apoptosis, and participates in the body's clearance and adaptability to pathogens Generation of an immune response. The currently discovered inflammasomes are ...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61P1/04A61P25/28A61P3/10A61P9/10A61P19/06A61P1/16A61P31/04
CPCA61K31/366A61P1/04A61P1/16A61P3/10A61P9/10A61P19/06A61P25/28A61P31/04
Inventor 柏兆方肖小河徐广石伟
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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