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Preparation method of organic phosphor-supported hollow mesoporous SiO2 hydrophilic phosphorescent nanoprobe

A nanoprobe and organophosphorus technology, which is applied in the field of preparation of hollow mesoporous SiO2 hydrophilic phosphorescent nanoprobes loaded with organic phosphors, can solve the problems of insufficient removal of PS template spheres and cumbersome removal of PS template spheres

Inactive Publication Date: 2019-09-06
HARBIN INST OF TECH SHENZHEN GRADUATE SCHOOL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technical solution uses DMF to remove the PS template ball is too cumbersome, and the removal of the PS template ball is not thorough enough

Method used

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  • Preparation method of organic phosphor-supported hollow mesoporous SiO2 hydrophilic phosphorescent nanoprobe
  • Preparation method of organic phosphor-supported hollow mesoporous SiO2 hydrophilic phosphorescent nanoprobe

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A Hollow Mesoporous SiO Loaded with Organic Phosphor 2 Hydrophilic phosphorescent nanoprobe preparation method, with reference to the specific route as figure 1 Shown:

[0025] (1). First, the template sphere PS (50 mg) was added into the flask, and then the surfactant triethanolamine (TEOA, 40 mg) and the porogen CTAB (75 mg) were added. After the mixture was heated to 80°C, a certain amount of silicon source TEOS (100 μL) was added to grow a layer of mSiO on the surface of PS spheres. 2 .

[0026] (2). After the reaction was completed by calcination (723K) in a muffle furnace, the PS template spheres and CTAB were completely removed within a certain period of time (4h) to obtain HMSNPs.

[0027] (3). Mix HMSNPs with a saturated solution (toluene) containing organic phosphor (DCzEO), and make the solution enter the cavity of HMSNPs.

[0028] (4). The HMSNPs filled with a saturated solution were dried (dried overnight at room temperature), so that the organic phosph...

Embodiment 2

[0030] A Hollow Mesoporous SiO Loaded with Organic Phosphor 2 Hydrophilic phosphorescent nanoprobe preparation method, with reference to the specific route as figure 1 Shown:

[0031] (1). First, the template sphere PS (50 mg) was added into the flask, and then the surfactant triethanolamine (TEOA, 40 mg) and the porogen CTAB (75 mg) were added. After the mixture was heated to 80°C, a certain amount of silicon source TEOS (200 μL) was added to grow a layer of mSiO on the surface of PS spheres. 2 .

[0032] (2). After the reaction was completed by calcination (823K) in a muffle furnace, the PS template spheres and CTAB were completely removed within a certain period of time (8h) to obtain HMSNPs.

[0033] (3). Mix HMSNPs with a saturated solution (dichloromethane) containing organic phosphor (MCzT), and make the solution enter the cavity of HMSNPs.

[0034] (4). The HMSNPs filled with a saturated solution were dried (dried overnight at room temperature), so that the organic...

Embodiment 3

[0036] A Hollow Mesoporous SiO Loaded with Organic Phosphor 2 Hydrophilic phosphorescent nanoprobe preparation method, with reference to the specific route as figure 1 Shown:

[0037] (1). First, the template sphere PS (100 mg) was added into the flask, and then the surfactant triethanolamine (TEOA, 80 mg) and the porogen CTAB (150 mg) were added. After the mixture was heated to 80°C, a certain amount of silicon source TEOS (200 μL) was added to grow a layer of mSiO on the surface of PS spheres. 2 .

[0038] (2). After the reaction is completed by calcination (823K) in a muffle furnace, the PS template spheres and CTAB are completely removed within a certain period of time (6h), thereby obtaining HMSNPs.

[0039] (3). Mix HMSNPs with a saturated solution (toluene) containing organic phosphor (CPhCz), and make the solution enter the cavity of HMSNPs.

[0040] (4). The HMSNPs filled with a saturated solution were dried (overnight under vacuum at room temperature), so that th...

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Abstract

The invention belongs to the technical field of preparation of materials, and concretely relates to a preparation method of an organic phosphor-supported hollow mesoporous SiO2 hydrophilic phosphorescent nanoprobe. The hydrophilic phosphorescent nanoprobe (Phosphors@HMSNPs) prepared by the preparation method combines the respective advantages of an organic phosphorescent crystal with hollow mesoporous silica nanoparticles (HMSNPs), can efficiently emit phosphorescence and can be stably dispersed in the water environment, so the nanoprobe can be used for phosphorescent bioimaging.

Description

technical field [0001] The invention belongs to the technical field of material preparation, in particular to a hollow mesoporous SiO loaded with an organic phosphor 2 Preparation method of hydrophilic phosphorescent nanoprobe. Background technique [0002] Ultra-long organic phosphorescence can eliminate the interference caused by transient background fluorescence and significantly increase the signal-to-noise ratio, so it is very suitable for biological imaging. [0003] Under the action of molecular motion and quenching factors such as oxygen and water molecules in the environment, non-metallic organic phosphors undergo fast non-radiative transitions, which limit their phosphorescence performance. Today, crystallization is considered as one of the effective ways to suppress nonradiative transitions, which can provide rigid confinement for phosphorescent molecules. However, most organic crystals are oil-soluble and cannot be well dispersed in aqueous environments, which ...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/06G01N21/64B82Y30/00
CPCC09K11/06C09K11/025G01N21/6428B82Y30/00C09K2211/1059C09K2211/1029C09K2211/1092
Inventor 马星黄维安众福史慧芳游勇强黄凯薇
Owner HARBIN INST OF TECH SHENZHEN GRADUATE SCHOOL
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