Building for femoral epicondyle tuberculosis animal model

An animal model, femoral condyle technology, applied in animal husbandry, etc., can solve problems such as high complications and mortality

Inactive Publication Date: 2019-08-30
中国人民解放军总医院第八医学中心
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Problems solved by technology

Several articular tuberculosis models established decades ago are not suitable for evaluating sustained-release materials for anti-tuberculosis drugs because the model has high morbidity and mortality during complex surgical procedures

Method used

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  • Building for femoral epicondyle tuberculosis animal model
  • Building for femoral epicondyle tuberculosis animal model

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Embodiment Construction

[0009] In the following, the technical solutions in the embodiments of the present invention will be described in detail with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0010] It should be noted that, in this document, the terms "comprising", "comprising" or any other variation thereof are intended to cover a non-exclusive inclusion such that a process, method, article or apparatus comprising a set of elements includes not only those elements, It also includes other elements not expressly listed, or elements inherent in the process, method, article, or apparatus.

[0011] figure 1 It is the H37Rv infection model of ...

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Abstract

The invention relates to building for a femoral epicondyle tuberculosis animal model, in particular to building of a rabbit femoral epicondyle tuberculosis animal model by using an H37Rv tuberculosisstrain. The model is an ideal platform for evaluating the effect of a drug delivery system in vivo. According to the method, the rabbit femoral epicondyle tuberculosis animal model is built by using the H37Rv tuberculosis strain, and the model is the ideal platform for evaluating the effect of the drug delivery system in vivo. The effectiveness and feasibility of the model are evaluated through gross specimen observation, Micro-CT examination, histological examination, mycobacterium culture and DNA micro-array testing. The femoral epicondyle animal model has the following advantages that the trauma is small in the preparation process, the operation is safe, and the model facilitates implantation of a material.

Description

technical field [0001] The invention relates to the construction of an animal model of femoral condyle tuberculosis, in particular to the establishment of a rabbit femoral condyle tuberculosis animal model by using H37Rv tuberculosis strain, which is an ideal platform for evaluating the effect of a drug delivery system in vivo. Background technique [0002] In 2016, the World Health Organization announced that there were 10.4 million new tuberculosis cases and 1.4 million tuberculosis deaths worldwide in 2015. Although the incidence of tuberculosis has been steadily decreasing year by year, it is still a major disease that endangers human health. Bone and joint tuberculosis is the most common extrapulmonary tuberculosis, accounting for 3% to 5% of all tuberculosis patients, often involving vertebral bodies and weight-bearing bones, leading to severe bone destruction. Surgery is appropriate for patients with severe complications. However, in recent years, the treatment of b...

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Application Information

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IPC IPC(8): A01K67/02
CPCA01K67/02
Inventor 崔旭翁杰
Owner 中国人民解放军总医院第八医学中心
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