Gastrointestinal malignant tumor marker and application thereof

A technology for malignant tumors and the gastrointestinal tract, applied in the field of gastrointestinal malignant tumor markers, can solve the problems of hidden onset, low survival rate, and difficult treatment of gastrointestinal malignant tumors, and achieve the ability to inhibit proliferation and migration, The effect of high sensitivity and strong specificity

Active Publication Date: 2019-08-16
HENAN UNIVERSITY
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  • Abstract
  • Description
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Problems solved by technology

However, the onset of gastrointestinal malignant tumors is hidden, and there are no obvious symptoms during the incubation period. When obvious symptoms appear, most of them have progressed to the middle and late stages, and the treatment is difficult. This also leads to the 5-year survival rate of patients with gastric cancer and colorectal cancer in my country is lower than the global level. one of the important reasons

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  • Gastrointestinal malignant tumor marker and application thereof
  • Gastrointestinal malignant tumor marker and application thereof
  • Gastrointestinal malignant tumor marker and application thereof

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Embodiment Construction

[0026] The technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0027] The overexpression of WNT4 gene in the present invention includes activating the coding gene of WNT4, increasing the copy number of WNT4 gene, activating or improving the transcription or translation of WNT4 gene, and promoting the whole biological process of WNT4 protein function.

[0028] In some specific embodiments, the drug can be added with one or more pharmaceutically acceptable adjuvants, including but not limited to known drug adjuvants such as granules, buffers, and surfactants. ...

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Abstract

The invention relates to the field of a biomedicine, in particular to a gastrointestinal tumor marker and an application thereof. The marker is WNT4. The gastrointestinal malignant tumor is human gastrointestinal malignant tumor tissue, including gastric cancer and colorectal cancer. The marker is used for preparing a reagent for early diagnosis of gastrointestinal malignant tumor, a fluorescencequantitative PCR primer pair of WNT4 is used, a cDNA of a sample to-be-tested is used as a template for performing a quantitative PCR reaction, and a CT value of WNT4 amplification is measured, and the CT value of an internal reference gene beta-actin is used for standardization correction to identify the sample to-be-tested. Through a reliable fluorescent quantitative PCR method, the expression level of WNT4 in the gastrointestinal malignant tumor tissue is significantly reduced through screening. The method has high sensitivity and strong specificity, and the marker can be used for early diagnosis of gastrointestinal malignant tumors.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a gastrointestinal cancer marker and its application. Background technique [0002] With the development of society and economy and the change of dietary structure, the incidence of malignant tumors of gastrointestinal tract is increasing year by year. Gastrointestinal malignancies include gastric cancer and colorectal cancer. According to the latest statistics in 2018, gastric cancer and colorectal cancer rank third and fourth in the incidence and mortality of cancer in my country, posing a serious threat to people's lives and health. The gastrointestinal tract is the most important organ for digestion and absorption of nutrients in the human body, and the occurrence of malignant tumors in the gastrointestinal tract has a similar pathophysiological basis. Although a series of progress has been made in the mechanism of its occurrence, the exact etiology is still not completely clear....

Claims

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Application Information

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IPC IPC(8): C12Q1/6886A61K45/00A61P35/00
CPCA61K45/00A61P35/00C12Q1/6886C12Q2600/158C12Q2600/166
Inventor 陈卫东聂小博王艳东叶文凌赵世振
Owner HENAN UNIVERSITY
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