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Continuous type centrifugal machine used for cell separation

A centrifuge and cell technology, applied in the direction of centrifuge, etc., can solve the problems of cell activity, cumbersome centrifugation operation, etc., and achieve the effect of improving centrifugation efficiency, simple and reasonable operation, and ensuring a sterile environment

Inactive Publication Date: 2019-08-09
哈尔滨工大国际干细胞工程研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem that the existing centrifugation device is cumbersome to perform centrifugation, and has an impact on cell activity, and the need to remove impurities after centrifugation is cumbersome, and then provides a continuous centrifuge for cell separation

Method used

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  • Continuous type centrifugal machine used for cell separation
  • Continuous type centrifugal machine used for cell separation
  • Continuous type centrifugal machine used for cell separation

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specific Embodiment approach 1

[0012] Specific implementation mode one: combine Figure 1-Figure 4 Describe this embodiment, a continuous centrifuge for cell separation described in this embodiment, which includes a rotary closed liquid inlet module 1, a swing stirring mechanism 2, a rotating platform 3, a transmission mechanism 4, a hollow main shaft 5, and a drive motor 6 and the conductive slip ring 7; the drive motor 6 is set close to the conductive slip ring 7, the bottom end of the hollow main shaft 5 is fixedly installed on the rotor shaft of the conductive slip ring 7, and the top of the hollow main shaft 5 passes through the rotating platform 3 and the rotary sealing liquid inlet module 1 The bottom end of the hollow main shaft 5 is fixed, the outer wall of the hollow main shaft 5 is fixedly connected with the rotating platform 3, the shell of the rotary closed liquid inlet module 1 is fixedly connected with the fixed frame, the output end of the rotating shaft of the driving motor 6 is connected wi...

specific Embodiment approach 2

[0013] Specific implementation mode two: combination figure 2 Describe this embodiment, a continuous centrifuge for cell separation described in this embodiment, the rotary seal liquid inlet module 1 includes a liquid inlet pipe 1-1, a rotary seal seat 1-2, a throat 1-3, a neck Tube 1-5, sealing cover 1-6, two rotary sealing rings 1-4, two neck tube liquid outlet joints 1-7 and two neck tube liquid inlet joints 1-8; the outer wall of the rotary seal seat 1-2 It is fixedly connected with the fixed frame, the liquid inlet pipe 1-1 is sealed and connected with one end of the throat pipe 1-3, the throat pipe 1-3 is inserted into the inner cavity at the top of the rotary sealing seat 1-2, and the top end of the neck pipe 1-5 protrudes The upper end of the neck tube 1-5 is installed in the shell of the rotary seal seat 1-2, and the raised top and bottom end of the neck tube 1-5 are connected and installed in the shell of the rotary seal seat 1-2 through two rotary seal rings 1-4. ...

specific Embodiment approach 3

[0014] Specific implementation mode three: combination figure 2 This embodiment is described. In the continuous centrifuge for cell separation described in this embodiment, the convex outer circular surface at the top of the neck tube 1-5 is processed with external threads. The screwing direction of the protruding external thread of the neck tube 1-5 is the same as the rotation direction of the neck tube 1-5, and there is a seal between the rotating seal seat 1-2, the protrusion of the neck tube 1-5 and the two rotating sealing rings 1-4. The lubricating liquid drives the lubricating liquid to move upward through the rotation of the neck tube 1-5, thereby increasing the sealing effect between the rotating sealing ring 1-4 and the neck tube 1-5. Other methods are the same as in the first embodiment.

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Abstract

The invention discloses a continuous type centrifugal machine used for cell separation, relates to a continuous separating device, and aims to solve the problem that impurity removal operation after centrifuging is complex as influences are caused on cell activity while complex centrifugal operation is performed on an existing centrifugal device. The continuous type centrifugal machine comprises arotary sealed liquid inlet module, a swing stirring mechanism, a rotary platform, a transmission mechanism, a hollow main shaft, a drive motor and a conductive slide ring, wherein the bottom end of the hollow main shaft is fixedly mounted on a rotor rotary shaft of the conductive slide ring; the top end of the hollow main shaft passes through the rotary platform and is fixed to the bottom end ofthe rotary sealed liquid inlet module; the output end of the rotary shaft of the drive motor is connected to the hollow main shaft through the transmission mechanism; the swing stirring mechanism is mounted on the rotary platform; and each outlet end of the rotary sealed liquid inlet module is in sealing connection to one inlet end of the swing stirring mechanism through a pipeline separately. Thecontinuous type centrifugal machine belongs to the technical field of biological cell separation.

Description

technical field [0001] The invention relates to a continuous separation device, in particular to a continuous separation and purification device for cells, belonging to the technical field of biological cell separation. Background technique [0002] The centrifuge is mainly used to separate the solid particles in the suspension from the liquid, or to separate two different densities and immiscible liquids in the emulsion. Taking advantage of the different sedimentation speeds of solid particles of different densities or particle sizes in liquids, some decanter centrifuges can also classify solid particles according to density or particle size. In biological experiments, centrifuges can be used to separate cells from culture fluid, sol and other substances. [0003] At present, there are some problems in the existing centrifugal devices. First, the separation and purification of ordinary centrifuges are generally carried out in steps, which is troublesome and some disturbing...

Claims

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Application Information

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IPC IPC(8): B04B5/04B04B11/04B04B9/02
CPCB04B5/0421B04B9/02B04B11/04
Inventor 佟明斯李湛林伟阳高会军杨宪强王娇
Owner 哈尔滨工大国际干细胞工程研究院有限公司
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