In-situ preparation and application method for povidone iodine-based antimicrobial micro-nano fiber dressing

A nanofiber, in-situ preparation technology, used in fiber treatment, medical science, absorbent pads, etc., can solve the problems of difficulty in fitting the fibrous membrane dressing to the wound surface, secondary wound damage, etc., achieving good antibacterial effect and reducing irritation. , the effect of good air permeability

Inactive Publication Date: 2019-08-09
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This traditional application method puts forward high requirements on the nursing staff, that is, it cannot cause secondary damage to the wound, and it is difficult for the fiber membrane dressing to fit well with the wound sur

Method used

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  • In-situ preparation and application method for povidone iodine-based antimicrobial micro-nano fiber dressing
  • In-situ preparation and application method for povidone iodine-based antimicrobial micro-nano fiber dressing

Examples

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Effect test

Embodiment 1

[0017] Step 1: Take by weighing 1.5 grams of polyvinylpyrrolidone powder (PVP, molecular weight 1.3 million), all dissolved in 8.5 grams of absolute ethanol, magnetically stirred at room temperature for 8 hours until completely dissolved, to obtain a uniform PVP spinning with a solute mass fraction of 15 wt%. silk precursor;

[0018] Step 2: Weigh 1.0 gram of iodine elemental substance and dissolve it in 9.0 gram of absolute ethanol, stir magnetically at room temperature for 2 hours until completely dissolved, and obtain a uniform iodine solution with a solute mass fraction of 10 wt %;

[0019] Step 3: Add the iodine solution prepared in step 2 to the spinning precursor solution prepared in step 1, the amount added makes the mass percentage of iodine simple substance in the solution 5%, stir for 2 hours, and make it mix uniformly , after standing still for 2 hours, a uniform and stable spinning precursor solution was obtained;

[0020] Step 4: Add the spinning precursor solut...

Embodiment 2

[0023] Step 1: Take 1.0 gram of polyvinyl butyral (PVB, molecular weight is 90000), dissolve it completely in 9.0 gram of absolute ethanol, stir magnetically at room temperature for 8 hours until completely dissolved, and obtain a homogeneous solution with a solute mass fraction of 10 wt%. PVB solution;

[0024] Step 2: Take 1.0 gram of polyvinylpyrrolidone iodine (PVPI, molecular weight is 10000-40000), all dissolved in 9.0 gram of absolute ethanol, magnetically stirred at room temperature for 8 hours until completely dissolved, to obtain a solute mass fraction of 10wt% Uniform PVPI solution (iodine);

[0025] Step 3: the PVPI iodophor solution prepared in step 2 is added to the PVB solution prepared in step 1, the amount added makes the mass percentage of PVPI in the solution be 5%, stir for 2 hours, make it mix uniformly, and then After standing for 2 hours, a uniform and stable spinning precursor solution was obtained;

[0026] Step 4: Add the spinning precursor solution...

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Abstract

The invention discloses an in-situ preparation and application method for an povidone iodine-based antimicrobial micro-nano fiber dressing. The method comprises the steps that a high-molecular polymeris totally dissolved with absolute ethyl alcohol, and a high-molecular solution is prepared; an povidone iodine-based material is dissolved into the high-molecular solution and stirred until to be totally uniform, and a spinning precursor solution is obtained; the prepared spinning precursor solution is added into a syringe, the syringe is put into a portable electrostatic spinning device, the device is started, a spinning parameter is adjusted until fibers are uniformly sprayed out, the spacing distance between a sprayer mouth and a receiving wound is controlled, and then it can be achievedthat the antimicrobial nanometer fiber dressing can be prepared on the wound in situ. The preparation method can make the antimicrobial fiber film dressing perfectly fit the wound through the action of electrostatic force, and the nanometer fiber film is high in air permeability. Besides, povidone iodine is used as an antimicrobial component, the cost is low, the antimicrobial effect is good, andthe irritation of a common povidone iodine solution to the wound can be reduced. The in-situ preparation and application method is wide is application prospect.

Description

technical field [0001] The invention belongs to the field of medical dressings, and in particular relates to a method for in-situ preparation and application of iodophor-based micro-nano fiber antibacterial dressings. Background technique [0002] The skin is the largest organ of the human body and the first barrier of human body protection. It protects various tissues and organs in the body from physical, mechanical, chemical and pathogenic microorganisms, but it will be exposed to the external environment all the time. Causes different types of injuries, mainly acute (such as surgical and traumatic wounds, abrasions and burns) and chronic (such as diabetic foot ulcers and pressure ulcers). According to World Health Organization (WHO) estimates, there are approximately 41 million trauma cases worldwide each year, with an annual economic burden of more than $670 billion. Thus, human skin trauma imposes a considerable social and economic burden on healthcare systems worldwid...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61L15/24D01D5/00
CPCA61L15/24A61L15/44A61L2300/106A61L2300/404D01D5/003C08L39/06C08L29/14
Inventor 闫芳芳闫旭张迪安郭浩刘国赛
Owner QINGDAO UNIV
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