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Application of irisin for preparing medicine for preventing and treating postoperative cognition impairment and blood brain barrier damaged mediated encephalopathy

A technology for cognitive dysfunction and blood-brain barrier, applied in the field of irisin, can solve problems such as little effect, and achieve the effects of reducing expression, reducing the expression of inflammatory factors, and inhibiting nuclear translocation

Active Publication Date: 2019-08-09
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, neuroprotection is also considered as one of the treatment methods, but these measures have little effect in clinical treatment

Method used

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  • Application of irisin for preparing medicine for preventing and treating postoperative cognition impairment and blood brain barrier damaged mediated encephalopathy
  • Application of irisin for preparing medicine for preventing and treating postoperative cognition impairment and blood brain barrier damaged mediated encephalopathy
  • Application of irisin for preparing medicine for preventing and treating postoperative cognition impairment and blood brain barrier damaged mediated encephalopathy

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 irisin efficacy experiment

[0042] 1. Experimental animals

[0043] Male, healthy SPF mice, including adults and old age, were purchased from the Animal Center of Peking University Health Science Center.

[0044] 2. Experimental conditions

[0045] Raising conditions for mice The ambient temperature is 22±0.5°C, with 12h / 12h alternating light and dark.

[0046] 3. Experimental process

[0047] The experimental data are represented by mean ± standard error, *P<0.05, **P<0.01, ***P<0.001, n=12.

[0048] Behavioral results: Abscissa: Sample represents the mouse exploring two objects freely before the OPR / NOR changed position; Test represents the process of changing the position of one of the objects after a period of time and allowing the mouse to explore again. The vertical axis represents the laterality score for exploring new objects, calculated as the exploration time.

[0049] After 7 days of adaptive culture with common feed, the mice were divided ...

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Abstract

The invention provides application of irisin for preparing a medicine for preventing and treating postoperative cognition impairment and blood brain barrier damaged mediated encephalopathy, and belongs to the technical field of medicine preparation. Irisin reduces oxidative stress caused by anesthesia operation by inhibiting activation of small colloid cells in CNS, expression of inflammatory factors is reduced, nucleus transcription factor NF-kB nuclear shifting is inhibited, then expression of downstream inflammatory factors is lowered, wherein the downstream inflammatory factors mainly include interleukin-1beta(IL-1beta) and interleukin-18(IL-18), burnt death, apoptosis and death of neuronal cells are reduced, rolling and wall adhesion of leukocytes in micro circulation are reduced, andtherefore the inflammatory is resisted, blood brain barriers are protected, and the postoperative cognitive impairment is improved.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to the application of irisin in the preparation and prevention of postoperative cognitive dysfunction and encephalopathy mediated by damaged blood-brain barrier. Background technique [0002] Postoperative cognitive dysfunction (POCD, Postoperative Cognitive Dysfunction) is one of the serious long-term complications of patients after surgery. The continuous decline in function, accompanied by the decline in social activities, lasts for several days to several years, which leads to delayed recovery, increased incidence of other types of complications, increased mortality, prolonged hospitalization days, and increased medical expenses. In patients undergoing high-risk surgery, especially the elderly, orthopedic or cardiac surgery patients, the incidence rate can be as high as 53%, and symptoms in a small number of patients (1%) can last for 1 to 2 years after surgery. Es...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/22A61P25/28A61P25/00A61P29/00A61K49/00
CPCA61K38/22A61P25/28A61P25/00A61P29/00A61K49/0008
Inventor 万有王佳昕伊鸣刘风雨崔爽
Owner PEKING UNIV
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