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Drug composition for treating endometrial cancer

A technology of endometrial cancer, composition, applied in the field of medicine

Inactive Publication Date: 2019-07-30
栾云鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the prognosis of endometrial cancer patients has been significantly improved with the help of early diagnosis and continuous improvement of treatment methods, nearly half of endometrial cancer patients are still diagnosed at advanced stage or due to recurrence and metastasis after surgery. Advanced disease state with no chance of cure

Method used

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  • Drug composition for treating endometrial cancer
  • Drug composition for treating endometrial cancer
  • Drug composition for treating endometrial cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] This embodiment provides an injection of a pharmaceutical composition for the treatment of endometrial cancer. The operation is as follows: Weigh 500 mg of industrial hemp flower and leaf extract and 400 mg of artesunate, add 200 mL of water for injection, and adjust with 8% NaOH solution PH value to make it dissolve; add 3g of sodium chloride, add 0.2% activated carbon and boil for 15 minutes, filter, add water for injection to the filtrate to 1000mL; filter the medicinal solution with 0.22μm microporous membrane, fill 5 bottles, and cap , Autoclave at 110°C for 40 minutes to obtain the injection form of the present invention.

Embodiment 2

[0026] This embodiment provides a drop pill of a pharmaceutical composition for the treatment of endometrial cancer. The operation is as follows: weigh 50 g of industrial hemp flower leaf extract, 30 g of artemether, and take polyethylene glycol 4000 and polyethylene glycol 6000 appropriate amount, after heating and melting in a 80-85℃ water bath, add the weighed above two raw materials, mix them, keep the temperature at 75℃, drip into liquid paraffin (0-5℃) to make 1000 tablets, namely Obtain the dropping pill dosage form of the present invention.

[0027] Pharmacodynamic experiment

[0028] In order to better illustrate the purpose and advantages of the present invention, the present invention uses the following experimental examples to describe the effect of the present invention as an anti-tumor agent, indicating that the combined use of industrial hemp compounds and artemisinin compounds can effectively inhibit endometrial cancer tumors Grow. The drug dosages used in the exp...

experiment example 1

[0029] Experimental example 1: The effect of combined application of cannabidiol and artemisinin on the growth of endometrial cancer cells in nude mice

[0030] 1. Experimental materials

[0031] 1) Reagents: After dissolving CBD (Sigma, St. Louis, MO, USA) with ethanol, prepare a 1mg / ml solution with saline and store at 4°C; artemisinin (ART) and its derivative dihydroartemisinin (DHA) and Artesunate (ARS) were purchased from Macleans Biochemical Technology Co., Ltd., Shanghai, China, and 1% methylcellulose (purchased from Sigma-Aldrich, Shanghai, China) at 4 degrees The solution is dissolved and prepared into the corresponding solution, which is prepared for immediate use.

[0032] 2) Cells: human endometrial carcinoma cells HEC-1B

[0033] 3) Female nude mice, 4-5 weeks old

[0034] 2. Experimental grouping

[0035] 1) Control group: Nude mice were treated with an equal volume of drug solvent

[0036] 2) CBD treatment group: CBD 60mg / kg, intraperitoneal injection, once a day

[0037] ...

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PUM

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Abstract

The invention provides a combined drug effective for treating endometrial cancer, relates to a composition and a use method thereof, and belongs to the field of biopharmaceuticals. The composition contains a first active ingredient and a second active ingredient, wherein the first active ingredient refers to an industrial cannabis compound, and the second active ingredient refers to an artemisinincompound. The industrial cannabis compound and the artemisinin compound can be combined with each other and synergistically applied to preparation of anti-tumor drugs, and a good application prospectis obtained.

Description

Technical field [0001] The present invention relates to a combined drug containing industrial hemp compound and artemisinin compound. The combined drug can be used for preparing antitumor drugs, especially for the treatment of endometrial cancer. It belongs to the field of medical technology. Background technique [0002] Tumor is an out-of-control cell proliferation disease with complex causes and is affected by multiple genetic, epigenetic, abnormalities at the cellular and tissue levels. The high degree of variability at the genomic and epigenome level, the extreme heterogeneity of multiple biological levels from transcripts to proteins, and the strong adaptability to the environment are the fundamental reasons why tumors have become the most difficult and difficult diagnosis and treatment. [0003] Carcinoma of endometrium (carcinoma of endometrium) is a group of epithelial malignant tumors that occur in the endometrium, which usually occurs in perimenopausal and postmenopausa...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61K31/05A61P35/00A61P15/00
CPCA61K31/05A61K31/366A61P15/00A61P35/00A61K2300/00
Inventor 栾云鹏郑双庆李志朋李襄
Owner 栾云鹏
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