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Drug combination for treating breast cancer

A combined drug, breast cancer technology, applied in the field of medicine, can solve problems such as no cure

Inactive Publication Date: 2019-08-02
栾云鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the prognosis of breast cancer patients has been significantly improved with the help of early diagnosis and treatment methods, at present, nearly half of breast cancer patients are diagnosed with advanced disease at the first diagnosis or enter the advanced disease state due to recurrence and metastasis after surgery. no chance of cure

Method used

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  • Drug combination for treating breast cancer
  • Drug combination for treating breast cancer
  • Drug combination for treating breast cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] This embodiment provides an injection of a pharmaceutical composition for the treatment of breast cancer. The operation is as follows: Weigh 500 mg of industrial hemp flower leaf extract, 500 mg of artesunate, add 200 mL of water for injection, and adjust the pH value with 8% NaOH solution Make it dissolve; add 3g of sodium chloride, add 0.2% activated carbon and boil for 15 minutes, filter, add water for injection to the filtrate to 1000mL; Autoclave at 110°C for 40 minutes to obtain the injection form of the present invention.

Embodiment 2

[0026] This embodiment provides a drop pill of a pharmaceutical composition for the treatment of breast cancer. The operation is as follows: Weigh 50 g of industrial hemp floral leaf extract, 50 g of artemether, and additionally take an appropriate amount of polyethylene glycol 4000 and polyethylene glycol 6000 After heating and melting in a water bath at 80-85°C, add the above-mentioned two raw materials weighed, mix well, keep the temperature at 75°C, drop into liquid paraffin (0-5°C), and make 1000 capsules to obtain this product Invented drop pill dosage form.

[0027] Pharmacological experiment

[0028] In order to better illustrate the purpose and advantages of the present invention, the present invention describes the effect of the present invention as an antitumor agent through the following experimental examples, illustrating that the combined use of industrial hemp compounds and artemisinin compounds can effectively inhibit endometrial cancer tumors grow. The doses...

experiment example 1

[0029] Experimental Example 1: The effect of combined application of cannabidiol and artemisinin on the growth of endometrial cancer cells in nude mice

[0030] 1. Experimental materials

[0031] 1) Reagent: CBD (Sigma, St. Louis, MO, USA) was dissolved in ethanol, then prepared into a 1mg / ml solution with normal saline, and stored at 4 degrees; artemisinin (ART) and its derivative dihydroartemisinin (DHA) and artesunate (ARS) were purchased from McLean Biochemical Technology Co., Ltd., Shanghai, China, and 1% methylcellulose (purchased from Sigma-Aldrich Company, Shanghai, China) refrigerated at 4 degrees. The solution is dissolved and prepared into a corresponding solution, which is prepared and used immediately.

[0032] 2) Cell: human breast cancer cell MDA-MB-231.

[0033] 3) Female nude mice, 4-5 weeks old.

[0034] 2. Experimental grouping

[0035] 1) Control group: Nude mice were treated with an equal volume of drug solution

[0036] 2) CBD treatment group: CBD 60...

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Abstract

The invention discloses a drug combination for treating breast cancer. The drug combination for treating the breast cancer contains first active ingredients of industry hemp compounds and second active ingredients of artemisinin compounds. Combined application of the industry hemp compounds and the artemisinin compounds can be used for preparing antineoplastic drugs, synergistic effects are obvious, and a very good application prospect is realized. The invention describes the composition and a preparation method thereof, and belongs to the technical filed of medicines.

Description

technical field [0001] The invention relates to a combined drug containing industrial hemp compounds and artemisinin compounds. The combined drug can be used to prepare antitumor drugs, especially drugs for treating breast cancer. It belongs to the field of medical technology. Background technique [0002] Cancer is a disease of uncontrolled cell proliferation with complex causes involving multiple abnormalities at the genetic, epigenetic, cellular and tissue levels. High variability at the genome and epigenome levels, extreme heterogeneity at multiple biological levels from transcripts to proteins, and strong adaptability to the environment are the fundamental reasons why tumors have become the most difficult and difficult diseases to diagnose and treat. [0003] Breast cancer (Metastatic breast cancer) is one of the most common malignant tumors in the world. It ranks first in the incidence of female tumors and seriously threatens the physical and mental health of women. 9...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61K31/366A61K31/357A61K31/05A61P35/00
CPCA61K31/05A61K31/357A61K31/366A61K36/60A61P35/00A61K2300/00
Inventor 栾云鹏郑双庆李志朋李襄
Owner 栾云鹏
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