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Application of rattlerin in preparing anti-fungal drug sensitizer

An antifungal drug, the technology of saipinin, which is applied in the field of biomedicine, can solve problems such as interference with propagation and growth, and tumor cell death, and achieve the effects of easy acquisition, strong synergy, and reduced clinical dosage

Active Publication Date: 2019-07-05
SHANGHAI CHANGZHENG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In a series of basic researches, it has been confirmed that saponin can induce tumor cell death and interfere with its dissemination and growth. At present, saponin has been widely studied in the fields of tumor biomolecules, but its antifungal properties The relationship between drugs has not been reported in relevant research

Method used

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  • Application of rattlerin in preparing anti-fungal drug sensitizer
  • Application of rattlerin in preparing anti-fungal drug sensitizer
  • Application of rattlerin in preparing anti-fungal drug sensitizer

Examples

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Embodiment Construction

[0017] The present invention will be described in detail in conjunction with the embodiments, but the implementation of the present invention is not limited thereto.

[0018] The reagents and raw materials used in the present invention are commercially available or can be prepared according to literature methods. For the experimental methods without specific conditions indicated in the following examples, usually follow the conventional conditions or the conditions suggested by the manufacturer. Percentages and parts are by volume unless otherwise indicated.

[0019] 1. Experimental materials

[0020] 1. Drugs and reagents

[0021] Fluconazole was purchased from SigmaAldrich Company in the United States, and chastein was purchased from Tocris Company in the United Kingdom, and were stored at -40°C; dimethyl sulfoxide (DMSO) was purchased from SigmaAldrich Company in the United States; ultra-clean water was purchased from Japan Net Water machine production.

[0022] 2. Stra...

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Abstract

The invention relates to the technical field of medical biological detection, and provides an application of rattlerin in preparing an anti-fungal drug sensitizer, an anti-fungal drug sensitizer taking rattlerin as an active ingredient and an anti-fungal combination preparation. According to experimental measurement, when fluconazole and rattlerin are combined, FICI of all experimental strains isless than or equal to 0.50, so that a strong synergistic effect is shown, meanwhile, the MIC value of fluconazole is decreased by 2-16 times, the sensitivity of fluconazole to cryptococcus is improved, so that the rattlerin not only is beneficial to reducing clinical dosage, but also is beneficial to slowing down the phenomenon of high drug resistance rate of cryptococcus, and conducts beneficialexploration for clinical anti-fungal infection.

Description

technical field [0001] The present invention relates to the technical field of biomedicine, and relates to the new application of saponin, especially the application in the preparation of antifungal drug sensitizers. Background technique [0002] The number of immunocompromised populations affected by HIV infection, malignant tumors, radiotherapy and chemotherapy, organ or stem cell transplantation, and autoimmune diseases continues to increase, as well as the abuse of broad-spectrum antibiotics, long-term use of immunosuppressants, and new treatments such as catheter intervention The morbidity and mortality of invasive fungal infection (cryptococcosis) have risen rapidly due to the continuous expansion of operating techniques and other factors. With the continuous use of antifungal drugs, the phenomenon of fungal drug resistance has become more and more common in the past 10 years, and the degree of drug resistance has also increased. In contrast, there has been no investme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P31/10A61K31/4196
CPCA61K31/352A61K31/4196A61P31/10A61K2300/00
Inventor 张超雷岩方伟朱信霖廖万清
Owner SHANGHAI CHANGZHENG HOSPITAL
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