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Drug for stable stage of chronic obstructive pulmonary diseases and preparation method thereof

A technology for chronic obstructive pulmonary disease and stable stage, which is applied in drug combinations, pharmaceutical formulations, respiratory diseases, etc., can solve the problem of chronic progressive disease and repeated exacerbation of the disease. It is flexible, accurate, effective, difficult to grasp the internal law of differentiation and treatment, etc., to achieve the effect of improving spleen and stomach function, inhibiting and reducing pulmonary fibrosis, and improving overall health and nutritional status

Inactive Publication Date: 2019-06-28
GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still many problems as follows: First, the chronic progression and repeated aggravation of the disease have not been fundamentally resolved and controlled.
Even if there are summaries of experience and laws, they are fragmented, and it is difficult to see the whole picture of pathogenesis changes and grasp the internal laws of differentiation and treatment.
Although each treatise has its own unique elaboration on the pathogenesis of COPD, but it is not comprehensive and clear enough, the evidence is less, the reliability is not enough, and the convincing force is not enough, so it is not possible to flexibly and effectively treat each stage of COPD based on the experience of one family.
However, if there is no comprehensive and clear law of pathogenesis changes to guide practice, it is difficult to achieve flexible, accurate and effective treatment based on syndrome differentiation.

Method used

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  • Drug for stable stage of chronic obstructive pulmonary diseases and preparation method thereof
  • Drug for stable stage of chronic obstructive pulmonary diseases and preparation method thereof
  • Drug for stable stage of chronic obstructive pulmonary diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0160] Example 1: A medicine for the stable stage of chronic obstructive pulmonary disease, the medicinal active ingredients are 15g Radix Astragali, 15g Sun-dried Ginseng, 15g Lily, 10g Digupi, 15g Sun-dried Ephedra, 10g Almond, 15g Atractylodes Rhizome, Gecko 6g, Fritillaria 15g, Trichosanthes 15g, Trichosanthes 15g, Poria cocos 15g, Tangerine peel 15g, Campanulaceae 15g, Pinellia fragrans 15g, Radix licorice 10g, Alisma 6g, Cortex paeonol 15g, Radix paeoniae Rubra 15g.

[0161] The medicine is a decoction, and the decoction is prepared in the following way: take the above-mentioned medicinal materials in proportion, mix them, add 3 times the amount of water to soak for 25 minutes, then decoct for 22 minutes, filter the medicine dregs while it is hot to retain the decoction A, and add to the medicine Add 3 times the amount of water to the dregs, decoct for 18 minutes, filter the dregs while hot to reserve decoction B, combine decoction A and decoction B to obtain the decoctio...

Embodiment 2

[0163] Embodiment 2: A kind of medicine that is used for the stable stage of chronic obstructive pulmonary disease, medicinal active ingredient is made up of Radix Astragali 5kg, raw sun-dried ginseng 5kg, lily 5kg, Digupi 5kg, roasted ephedra 5kg, almond 5kg, Atractylodes macrocephala 5kg, Gecko 1kg, Fritillaria 5kg, Trichosanthes 5kg, Trichosanthes 5kg, Poria cocos 5kg, Tangerine peel 5kg, Campanulaceae 5kg, Pinellia chinensis 5kg, Licorice 5kg, Alisma 1kg, Cortex paeonol 5kg, Paeoniae rufica 5kg.

[0164] The medicine is a granule, and the granule is prepared in this way: take the above-mentioned medicinal materials in proportion, crush them into the coarsest powder, add water to soak for 25 minutes, decoct three times, each time for 30 minutes, combine the decoction, filter, and concentrate the filtrate to 80 When ℃, the relative density is 1.33 thick paste, add the dextrin of 33% of production amount, the sucrose of 48% of production amount, mix evenly, make granule, dry, ...

Embodiment 3

[0166] Embodiment 3: A kind of medicine that is used for the stable stage of chronic obstructive pulmonary disease, medicinal active ingredient is made up of Radix Astragali Radix 30g, Sun-dried Ginseng 30g, Lily 30g, Digupi 20g, Sun-dried Ephedra 30g, Almond 20g, Atractylodes macrocephala 30g, Gecko 10g, Fritillaria 30g, Trichosanthes 30g, Trichosanthes 30g, Poria cocos 30g, Tangerine peel 30g, Campanulaceae 30g, Pinellia chinensis 30g, Radix licorice 20g, Alisma 10g, Cortex paeonol 30g, Radix paeoniae Rubra 30g.

[0167] The medicine is a decoction, and the decoction is prepared in the following way: take the above-mentioned medicinal materials in proportion, crush them into the coarsest powder, soak in water for 25 minutes, decoct 3 times, and decoct for 3 hours with 12 times the amount of water for the first time, For the second time, use 8 times the amount of water to decoct for 2 hours, and for the third time, use 6 times the amount of water to decoct for 0.5 hours, combi...

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Abstract

The invention discloses a drug for a stable stage of chronic obstructive pulmonary diseases and a preparation method thereof. The medicinal effective components are composed of radix astragali preparata, sun-dried ginseng, bulbus Lily, cortex lycii, herba ephedrae preparata, semen armeniacae amarum, rhizoma atractylodis, gecko, bulbus fritillariae thunbergii, seeds of snake gourds, radix trichosanthis, poria cocos, dried orange peels, radix platycodi, rhizoma pinelliae preparata, radix glycyrrhizae preparata, rhizoma alismatis, cortex moutan and radix paeoniae rubra. The drug has the effects of tonifying deficiency (invigorating qi-yin of the lung and invigorating qi of the spleen and kidney), eliminating phlegm, removing dampness, facilitating diuresis, promoting blood circulation, removing blood stasis, nourishing yin, clearing away internal heat, ventilating the lung and unclogging the viscera. The drug can be used in the stable stage of chronic obstructive pulmonary diseases, improve immunity, reduce the frequency of acute aggravation induced by infection, improve the lung function, promote oxygenation, control the disease progress and relieve cough, expectoration, asthma, anddyspnea.

Description

technical field [0001] The invention relates to a medicine for stable chronic obstructive pulmonary disease and a preparation method thereof, belonging to the field of pharmaceutical technology. Background technique [0002] Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable disease characterized by persistent airflow limitation, progressive development, and chronic inflammation of the airways and lungs to noxious particles or gases associated with heightened sexual response. [0003] According to statistics, the number of patients with COPD exceeded 380 million in 2010, and the global prevalence rate is about 11.7%, with a 95% confidence interval (confidence interval, CI) of 8.4% to 15%. COPD is currently recognized as the fourth leading cause of death in the world, and it is expected to rank third in the world in the next 5-10 years. COPD imposes a considerable economic burden globally: in Europe, respiratory diseases account for 6% of nat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8967A61P11/00A61P9/00A61K35/583
Inventor 李正欢张怡刘昕
Owner GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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