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A kind of animal model and construction method of metabolic syndrome in children and adolescents

A technology of metabolic syndrome and construction method, which is applied in the field of animal model and establishment of metabolic syndrome induced by high-fat and high cholesterol in children and adolescents, can solve the problems of one or several diseases in the model, and can relieve indigestion and improve the Adaptability and the effect of ensuring the success rate of modeling

Active Publication Date: 2021-06-01
凯斯艾生物科技(苏州)有限公司
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Problems solved by technology

In the prior art, the method of using high-fat and high-cholesterol feed for modeling is mostly used in the establishment of animal models of non-alcoholic fatty liver disease, atherosclerosis, exogenous hyperlipidemia, etc. However, these models usually only have one symptoms of several diseases

Method used

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  • A kind of animal model and construction method of metabolic syndrome in children and adolescents
  • A kind of animal model and construction method of metabolic syndrome in children and adolescents
  • A kind of animal model and construction method of metabolic syndrome in children and adolescents

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Embodiment Construction

[0047] The specific steps of the present invention are illustrated below through the examples, but not limited by the examples.

[0048] The terms used in the present invention, unless otherwise specified, generally have the meanings commonly understood by those skilled in the art.

[0049] The present invention will be further described in detail below in conjunction with specific examples and with reference to data. It should be understood that this example is only to illustrate the present invention, but not to limit the scope of the present invention in any way.

[0050] In the following examples, various procedures and methods not described in detail are conventional methods well known in the art.

[0051] The present invention will be further described below in conjunction with specific examples.

[0052] Animals: male SPF grade New Zealand experimental white rabbits, 7 weeks old, raised in a general grade animal breeding center, 12 hours of light / 12 hours of no light,...

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Abstract

The invention discloses a method for constructing an animal model of metabolic syndrome in children and adolescents, which adopts a staged feeding method and uses common maintenance feed, high-fat and high-cholesterol feed and forage to feed 6-8-week-old (childhood) animals in combination. Rabbits have successfully established animal experimental models of metabolic syndrome in children and adolescents. The model also has early coronary heart disease, atherosclerosis, fatty liver, non-alcoholic steatohepatitis, liver fibrosis, proteinuric nephropathy and other disease symptoms caused by metabolic syndrome, and can be used for metabolic syndrome and its concurrent diseases. Etiology, pathological research and pharmaceutical evaluation of multiple organ lesions.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to an animal model of metabolic syndrome induced by high fat and high cholesterol in children and adolescents and a method for establishing it. Background technique [0002] Metabolic syndrome (MS) is a pathological state of abnormal aggregation of various metabolic components, mainly manifested as: abdominal obesity or excess body mass, dyslipidemia, hypertension, insulin resistance and / or abnormal glucose tolerance, these metabolic disorder syndromes are cardiovascular High risk factors for disease and type 2 diabetes. In 2018, China's big health data revealed that my country's obese population reached 325 million, of which the obesity rate of children and adolescents accounted for 30%, and this figure will double in the next 20 years, reaching 650 million. The incidence of fatty liver in obese children and adolescents reaches 40-50%. In obese children and adolescents, these me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01K67/02
Inventor 庄永杰杨祖经陈继巧姜世浩靳策沈红英甘婷
Owner 凯斯艾生物科技(苏州)有限公司
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