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Pharmaceutical composition for treatment of hyperuricemia and preparation method of pharmaceutical composition

A technology of hyperuricemia and composition, applied in the field of medicine, can solve problems such as reducing blood uric acid, and achieve the effect of reducing blood uric acid, excellent blood uric acid reducing effect, and inhibiting activity

Inactive Publication Date: 2019-06-21
ZHONGSHAN FLASHLIGHT POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report on the combined use of Wuzhi Maotao, Phellinus Phellinus and Buza Ye to reduce blood uric acid

Method used

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  • Pharmaceutical composition for treatment of hyperuricemia and preparation method of pharmaceutical composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1, the preparation of pharmaceutical composition mixture of the present invention

[0037] Mix 100g of five-finger peach, 50g of Phellinus, and 50g of Buza leaves, add 2 times the amount (v / w) of water to soak for 30 minutes, decoct with 6 to 8 times the amount (v / w) of water each time, and decoct twice , each time for 30 to 60 minutes, combine the decoction, filter, and concentrate to about 1000mL.

Embodiment 2

[0038] Embodiment 2, the preparation of pharmaceutical composition granule of the present invention

[0039] Mix 100g of five-finger peach, 50g of Phellinus, and 50g of Buza leaves, add 2 times the amount (v / w) of water to soak for 30 minutes, decoct with 6 to 8 times the amount (v / w) of water each time, and decoct twice , each time for 30 to 60 minutes, combined decoction, filtered, concentrated under reduced pressure, dried by any method of normal pressure drying, reduced pressure drying, and spray drying, and then crushed to obtain dry cream powder, added dextrin and sucrose, mixed Uniformly, wet granulated, dried, granulated, divided into 100 bags, each bag containing 2.5g, to obtain sugar-containing granules. Or add other diluents and non-sugar sweeteners to the dry paste powder, mix well, wet granulate, dry, granulate, and pack into 100 bags, each containing 2.0g, to obtain non-sugar granules.

Embodiment 3

[0040] Embodiment 3, the preparation of pharmaceutical composition pill of the present invention

[0041] Mix 100g of five-finger peach, 50g of Phellinus japonica, and 50g of Buza leaves, pulverize into fine powder, pass through a 100-mesh sieve, and mix well. Add 190-210g of refined honey per 100g of powder to make big honeyed pills.

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Abstract

The invention provides a pharmaceutical composition for the treatment of hyperuricemia which is prepared from, by weight, 4-6 parts of radix fici simplicissimae, 2-3 parts of phellinus igniarius and 2-3 parts of folium microcotis. The invention further provides a preparation method of the pharmaceutical composiiton. In the composition, the radix fici simplicissimae, phellinus igniarius and foliummicrocotis are taken as crude drugs and have synergistic effect at a specific ratio, and good effect of reducing blood uric acid can be produced; the efficacy test shows that the pharmaceutical composition can reduce the blood uric acid and inhibit serum xanthine oxidase activity remarkably and a new selection is provided for clinical use of drugs to reduce serum uric acid and treating hyperuricemia.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for treating hyperuricemia and a preparation method thereof. Background technique [0002] Hyperuricemia (HUA) refers to the level of blood uric acid on an empty stomach that is higher than 420 μmol / L for men and higher than 360 μmol / L for women under a normal purine diet. Uric acid is one of the components of non-protein nitrogen in plasma, which is mainly derived from the catabolism of purine base in the nucleus protein in the body. Under normal circumstances, there are about 1,200 mg of uric acid in the body, about 600 mg is newly generated every day, and 600 mg is excreted at the same time, which is in a state of balance. However, if there is too much uric acid in the body and it is too late to excrete or the uric acid excretion mechanism degrades, the body will retain too much uric acid. When the blood uric acid concentration is greater than ...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61P19/06
Inventor 王琼张娜赵斌刘敬
Owner ZHONGSHAN FLASHLIGHT POLYTECHNIC
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