Quality evaluation method for Chinese herbal compound aconite lizhong decoction for treating gastric ulcer

A technology for the management and quality evaluation of aconite, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of failing to achieve quality control, and cannot accurately reflect the compound prescription of traditional Chinese medicine, etc., and achieve high sensitivity, simple and easy determination method, The effect of rapid evaluation

Active Publication Date: 2019-06-18
QIQIHAR UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the quality evaluation of traditional Chinese medicine compound is mostly determined by the content of a single index, but the curative effect of traditional Chinese medicine compound is the result of the synergistic effect of multiple components, so the content of a single index often cannot accurately reflect the quality of the traditional Chinese medicine compound, and cannot reach the real meaning On the quality control, while the simultaneous quantification of multiple indicators can solve the above problems and improve the controllability of the quality of traditional Chinese medicine compound

Method used

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  • Quality evaluation method for Chinese herbal compound aconite lizhong decoction for treating gastric ulcer
  • Quality evaluation method for Chinese herbal compound aconite lizhong decoction for treating gastric ulcer
  • Quality evaluation method for Chinese herbal compound aconite lizhong decoction for treating gastric ulcer

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Experimental program
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Effect test

Embodiment 1

[0038] According to the quality evaluation method of the traditional Chinese medicine Fuzi Lizhong Decoction for the treatment of gastric ulcer in this embodiment, the content limits of the 10 chemical components in the traditional Chinese medicine Fuzi Lizhong Decoction are respectively: benzoylaconitine 2.248 μg / g~ 2.864μg / g, Benzoyl neoaconitine 16.464μg / g~17.655μg / g, Atractylodes lactone I0.632μg / g~0.743μg / g, Atractylodeslide II4.158μg / g~4.667μg / g , Atractylodes lactone III 3.788μg / g~4.043μg / g, tangshenoside 51.802μg / g~53.089μg / g, liquiritin 15.664μg / g~16.987μg / g, liquiritin 5.918μg / g~6.042μg / g, 8-gingerol 2.282μg / g~3.127μg / g and 10-gingerol 1.600μg / g~1.985μg / g are qualified.

[0039] The composition of the traditional Chinese medicine compound aconite Lizhong Decoction is prepared aconite, codonopsis, dried ginger, atractylodes macrocephala and licorice of equal quality.

[0040]This embodiment also provides a quality evaluation method for the above-mentioned Chinese me...

Embodiment 2

[0058] According to the quality evaluation method of the traditional Chinese medicine Fuzi Lizhong Decoction for the treatment of gastric ulcer in this embodiment, the content limits of the 10 chemical components in the traditional Chinese medicine Fuzi Lizhong Decoction are respectively: benzoylaconitine 2.248 μg / g~ 2.864μg / g, Benzoyl neoaconitine 16.464μg / g~17.655μg / g, Atractylodes lactone I0.632μg / g~0.743μg / g, Atractylodeslide II4.158μg / g~4.667μg / g , Atractylodes lactone III 3.788μg / g~4.043μg / g, tangshenoside 51.802μg / g~53.089μg / g, liquiritin 15.664μg / g~16.987μg / g, liquiritin 5.918μg / g~6.042μg / g, 8-gingerol 2.282μg / g~3.127μg / g and 10-gingerol 1.600μg / g~1.985μg / g are qualified.

[0059] The composition of the traditional Chinese medicine compound aconite Lizhong Decoction is prepared aconite, codonopsis, dried ginger, atractylodes macrocephala and licorice of equal quality.

[0060] This embodiment also provides a quality evaluation method for the above-mentioned Chinese m...

Embodiment 3

[0075]According to the quality evaluation method of the traditional Chinese medicine Fuzi Lizhong Decoction for the treatment of gastric ulcer in this embodiment, the content limits of the 10 chemical components in the traditional Chinese medicine Fuzi Lizhong Decoction are respectively: benzoylaconitine 2.248 μg / g~ 2.864μg / g, Benzoyl neoaconitine 16.464μg / g~17.655μg / g, Atractylodes lactone I0.632μg / g~0.743μg / g, Atractylodeslide II4.158μg / g~4.667μg / g , Atractylodes lactone III 3.788μg / g~4.043μg / g, tangshenoside 51.802μg / g~53.089μg / g, liquiritin 15.664μg / g~16.987μg / g, liquiritin 5.918μg / g~6.042μg / g, 8-gingerol 2.282μg / g~3.127μg / g and 10-gingerol 1.600μg / g~1.985μg / g are qualified.

[0076] The composition of the traditional Chinese medicine compound aconite Lizhong Decoction is prepared aconite, codonopsis, dried ginger, atractylodes macrocephala and licorice of equal quality.

[0077] This embodiment also provides a quality evaluation method for the above-mentioned Chinese me...

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Abstract

The invention provides a quality evaluation method for Chinese herbal compound aconite lizhong decoction for treating gastric ulcer. The method defines content limits of 10 chemical components of benzoylaconitine, benzoylmesaconine, atractylenolide I, atractylenolide II, atractylenolide III, lobetyolin, liquiritin, liquiritigenin, 8-gingerol and 10-gingerol in the Chinese herbal compound aconite lizhong decoction; the content is determined through a liquid chromatography-mass spectrometry method; and meanwhile, the 10 chemical components are detected simultaneously. The method is used for evaluating the quality of the Chinese herbal compound aconite lizhong decoction for treating gastric ulcer. The content of the 10 chemical components in the Chinese herbal compound aconite lizhong decoction is detected through the liquid chromatography-mass spectrometry method, so that the 10 chemical components can be detected simultaneously and quantified through one injection; and the method is fast in determination, efficient, high in flexibility and simple and feasible in detection, and can quickly evaluate the quality of the Chinese herbal compound aconite lizhong decoction.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine treatment evaluation, and in particular relates to a quality evaluation method of Fuzi Lizhong Decoction, a traditional Chinese medicine compound for treating gastric ulcer. Background technique [0002] The traditional Chinese medicine compound "Fuzi Lizhong Decoction" has a therapeutic effect on gastric ulcers. The chemical composition of the traditional Chinese medicine compound is complex, and the sources of medicinal materials in the composition are different, resulting in large differences in the content of the main chemical components, and the drug effect may be lost during the decoction process. , easily lead to unstable quality of finished medicine, affecting efficacy. At present, there is no quality evaluation method for Fuzi Lizhong Decoction, so it is necessary to formulate its quality evaluation method to ensure the stability of curative effect. At present, the q...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/89
Inventor 辛杨
Owner QIQIHAR UNIVERSITY
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