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Ganoderma spore oil nanoemulsion and preparation method and application thereof

A technology of Ganoderma lucidum spore oil and nanoemulsion, which is applied in the fields of medical formula, emulsion delivery, and medical preparations of non-active ingredients, etc., which can solve the limitations of the practical application of Ganoderma lucidum spore oil, unfavorable promotion and development of spore oil, and ineffective use To achieve the effect of expanding free radical scavenging and antioxidant capacity, strong free radical scavenging ability, and reducing human and material resources

Active Publication Date: 2019-06-14
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the Ganoderma lucidum spore oil extracted at low temperature is an oily liquid at room temperature, which is extremely fat-soluble and difficult to be digested and absorbed by the human body. cause unnecessary waste
All of the above factors may limit the practical application of Ganoderma lucidum spore oil in the field of medicine and food
[0004] In recent years, the development of nanotechnology has also promoted the application and development of Ganoderma lucidum spore oil in the field of medicine. Many researchers have also carried out research on the improvement of its dosage form in related fields; but its preparation process is cumbersome and time-consuming, which is not conducive to Enables a wide range of production applications
Or in the synthesis process, adding a large amount of emulsifiers and co-emulsifiers and other components is expected to obtain nanoparticles with small particle size and uniform dispersion, but excessive addition of surfactants will also lead to an increase in their potential toxicity, which will instead cause biological damage. The application is limited, which is not conducive to the promotion and development of spore oil

Method used

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  • Ganoderma spore oil nanoemulsion and preparation method and application thereof
  • Ganoderma spore oil nanoemulsion and preparation method and application thereof
  • Ganoderma spore oil nanoemulsion and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1 Spore Oil Nanoemulsion GLSO@P188 / PEG 400 preparation of

[0059] A preparation method of Ganoderma lucidum spore oil nanoemulsion, comprising the steps of:

[0060] (1) Disperse Poloxamer P188 solid particles (Sigma, USA) in deionized water to prepare a solution with a mass fraction of 10%, and store it in a 4°C refrigerator for later use;

[0061] (2) Take 10 mL of Poloxamer 188 (P188) solution prepared in step (1) in a beaker, and then add 100 μL PEG 400 (U.S. Sigma Company), stirred at room temperature for 2 minutes, and the rotating speed was 500 rpm;

[0062] (3) Slowly inject 5 mL of Ganoderma lucidum spore oil (GLSO) into the system prepared in step (2), stir at room temperature for 5 minutes, and the rotation speed is 800 rpm; continue to slowly inject deionized water into it to make the colostrum solution final The volume is 50mL;

[0063] (4) The colostrum solution obtained in step (3) is transferred to a high-pressure homogenizer. First carry o...

Embodiment 2

[0064] Example 2 Preparation of spore oil nanoemulsion GLSO@P188 / PEG400

[0065] A preparation method of Ganoderma lucidum spore oil nanoemulsion, comprising the steps of:

[0066] (1) Disperse Poloxamer P188 in deionized water, prepare a solution with a mass fraction of 10%, store it in a refrigerator at 4°C, and set aside;

[0067] (2) Take 10 mL of Poloxamer 188 (P188) solution prepared in step (1), then add 100 μL PEG 400 , stirred at room temperature for 2 minutes, and the rotation speed was 500 rpm;

[0068] (3) Slowly inject 5 mL of Ganoderma lucidum spore oil (GLSO) into the solution prepared in step (2), stir at room temperature for 4 minutes, and the rotation speed is 800 rpm; continue to slowly inject deionized water into it to make the colostrum solution final The volume is 50mL;

[0069] (4) The colostrum solution obtained in step (3) is transferred to a high-pressure homogenizer. Firstly, preliminary homogenization is carried out, the homogenization pressure ...

Embodiment 3

[0070] Example 3 Preparation of spore oil nanoemulsion GLSO@P188 / PEG400

[0071] A preparation method of Ganoderma lucidum spore oil nanoemulsion, comprising the steps of:

[0072] (1) Disperse poloxamer P188 in deionized water, prepare a solution with a mass fraction of 10%, and set aside;

[0073] (2) Take 10 mL of poloxamer (P188) obtained in step (1), and then add 100 μL of PEG 400 , stirred at room temperature for 2 minutes, and the rotation speed was 300 rpm;

[0074] (3) Slowly inject 5 mL of Ganoderma lucidum spore oil (GLSO) into the solution obtained in step (2), stir at room temperature for 3 minutes, and the rotating speed is 800 rpm; continue to inject deionized water into it to make the colostrum solution final The volume is 50mL;

[0075] (4) The colostrum solution obtained in step (2) is transferred to a high-pressure homogenizer. First carry out preliminary homogenization, the homogenization pressure is 200 bar (bar), and the homogenization time is 2 minut...

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Abstract

The invention discloses a ganoderma lucidum spore oil nanoemulsion and a preparation method and application thereof. The ganoderma lucidum spore oil nanoemulsion is prepared from ganoderma lucidum spore oil, an emulsifier, a co-emulsifier and water, wherein the content of the ganoderma lucidum spore oil is 5-15% by volume, the content of the emulsifier is 2-11% by massic volume ratio, the contentof the co-emulsifier is 0.06-0.2% by volume, and the balance is water. After the emulsifier and the co-emulsifier are uniformly mixed, the ganoderma lucidum spore oil and water are added, and the ganoderma lucidum spore oil and water are homogenized to obtain the ganoderma lucidum spore oil nanoemulsion which is uniform, stable and safer; the consumed time is shortened, the used auxiliary materials are decreased, and the manpower and material cost in the preparation process is further reduced. By optimizing a formula and the preparation method, the obtained ganoderma lucidum spore oil nanoemulsion has strong free radical scavenging capacity, antioxidant capacity, antitumor effect and hypoglycemic effect, and simultaneously reduces the potential toxic effect of the auxiliary materials on the body, so that the ganoderma lucidum spore oil nanoemulsion has popularization significance.

Description

technical field [0001] The invention belongs to the fields of medicine and food, and in particular relates to a nanoemulsion of ganoderma lucidum spore oil and a preparation method and application thereof. Background technique [0002] In my country, the earliest TCM work on Ganoderma lucidum is "Shen Nong's Materia Medica", in which it is classified as "shang yao". Ganoderma lucidum spores are extremely fine particles ejected from the cap when the fruiting body of Ganoderma relies on mycelium to provide nutrition and mature. It is the germ cell of Ganoderma lucidum; It has multiple functions such as anti-oxidation, anti-tumor, improving body immunity, protecting nervous system, lowering blood lipid, anti-inflammation, and adjuvant chemotherapy and / or radiotherapy to treat tumors. It can be used for daily health care of middle-aged and elderly people and those with weak constitution, and can strengthen the body body, increase immunity, and prevent diseases, so it has increa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/074A61K9/107A61K47/10A61P35/00A61P39/06A61P3/10
Inventor 陈填烽代成俐
Owner JINAN UNIVERSITY
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