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Preparation method of hypromellose specially used for plant capsules

A technology of hypromellose and plant capsules, which is applied in capsule delivery, medical preparations of non-active ingredients, pharmaceutical formulas, etc., and can solve the problems that the production process of plant capsules cannot be continuous, and the design performance of the production line cannot fully adapt to the production process, etc. , to achieve uniform distribution of replacement positions, ensure continuous production, and controllable viscosity

Pending Publication Date: 2019-06-07
ANHUI SUNHERE PHARMA EXCIPIENTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reasons are roughly as follows: there is no raw material suitable for mass production of plant capsules; the special process and performance index requirements of hypromellose for capsules lead to the inability of continuous plant capsule production process; the design performance of the production line cannot fully meet the requirements of the production process; Application promotion requires a large enough volume and high quality hollow capsule products

Method used

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  • Preparation method of hypromellose specially used for plant capsules
  • Preparation method of hypromellose specially used for plant capsules
  • Preparation method of hypromellose specially used for plant capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method of special hypromellose for plant capsules, comprising the following steps:

[0027] S1. Alkali soaking of wood pulp board: add 1000kg of 50% sodium hydroxide solution in the alkali soaking tank. Fully soak the cut 200kg wood pulp board in the alkali soaking tank;

[0028] S2, pressing: squeeze the soaked pulp board, control the pressing pressure, the mass ratio of wood pulp pulp board to lye is 1:1.1, and roll the soaked pulp board into rolls for later use with a rewinder;

[0029] S3. Degradation: put the pressed pulp board into a drying room with a temperature of 50°C and a relative humidity of 60% for oxidative degradation for 24 hours;

[0030] S4. Dispersion: pump 800kg of toluene and 200kg of isopropanol into the batching tank, and at the same time control the solvent moisture requirement below 5%; put the degraded material into the reactor, stir for 30 minutes, and disperse the material in the solvent;

[0031] S5. Etherification reaction:...

Embodiment 2

[0035] A preparation method of special hypromellose for plant capsules, comprising the following steps:

[0036] S1, wood pulp board soaking in alkali: add 400kg of 50% sodium hydroxide solution in the alkali soaking tank. Fully soak the cut 100kg wood pulp board in the alkali soaking tank;

[0037] S2, pressing: squeeze the soaked pulp board, control the pressing pressure, the mass ratio of the wood pulp pulp board to the lye is 1:0.8, and roll the soaked pulp board into rolls for later use with a rewinder;

[0038] S3. Degradation: put the pressed pulp board into a drying room with a temperature of 65°C and a relative humidity of 50% for oxidative degradation for 24 hours;

[0039] S4. Dispersion: pump 850kg of toluene and 150kg of isopropanol into the batching tank, and at the same time control the solvent moisture to be less than 5%; put the degraded material into the reactor and stir for 30 minutes to disperse the material in the solvent;

[0040] S5. Etherification rea...

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Abstract

The invention discloses a preparation method of hypromellose specially used for plant capsules. The method comprises the following steps: wood pulp boards with a wide range of source are used as raw materials, soaking is performed by using an alkaline liquid, pressing is performed, coiling is performed, degradation is performed, so that a polymerization degree required for the hypromellose used for producing the capsules is achieved; and the obtained material is used as a raw material, an etherification reaction is performed, and therefore the hypromellose with a less viscosity range can be produced, wherein the high-concentration alkaline liquid has oxidative degradation effects on cellulose at a certain temperature, and can control a polymerization degree of the cellulose and improve accessibility of the cellulose, and the alkali cellulose can be used to prepare the hypromellose with a less viscosity range. The preparation process provided by the invention is simple, the viscosity ofthe product is adjustable, substitution positions of hydroxypropoxy are uniformly distributed, and the light transmittance and gel temperature of the product can meet capsule production requirements.

Description

technical field [0001] The invention belongs to the technical field of preparation of pharmaceutical excipients, and in particular relates to a method for preparing hypromellose special for vegetable capsules. Background technique [0002] Hollow capsules are the necessary carriers for capsule medicines, and their performance, quality and safety directly affect the effectiveness, stability and safety of medicines. For more than 100 years, animal gelatin hollow capsules have monopolized the market, and no new hollow capsule varieties have appeared. With the development and progress of capsule medicines, the performance defects of gelatin hollow capsules, such as high water content, unstable performance, susceptibility to bacteria, etc., and safety risks such as mad cow disease, foot-and-mouth disease, chromium pollution and drug residues are highlighted. Vegetable hollow capsules, which can completely overcome the defects and disadvantages of gelatin hollow capsules, emerged...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B11/08A61K9/48A61K47/38
Inventor 毕勇尹正龙侯俊峰李祥祥许宁
Owner ANHUI SUNHERE PHARMA EXCIPIENTS
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