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Glioma prognosis marker CPVL and application thereof

A prognostic marker, glioma technology, which can be applied in the determination/examination of microorganisms, biochemical equipment and methods, DNA/RNA fragments, etc. Not completely clear, etc.

Active Publication Date: 2019-05-31
THE FIRST AFFILIATED HOSPITAL OF WANNAN MEDICAL COLLEGE YIJISHAN HOSPITAL OF WANNAN MEDICAL COLLEGE
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Problems solved by technology

The current traditional therapies such as surgical resection, radiotherapy, and chemotherapy have not significantly improved the prognosis of patients with glioma, which has always been a major problem in the treatment of malignant tumors of the central nervous system. The fundamental reason is that the pathogenesis of glioma has not yet been fully aware

Method used

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  • Glioma prognosis marker CPVL and application thereof
  • Glioma prognosis marker CPVL and application thereof
  • Glioma prognosis marker CPVL and application thereof

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Embodiment Construction

[0045] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention.

[0046] refer to Figure 1-15 , a glioma prognostic marker CPVLmRNA, its sequence number is shown in Table 1.

[0047] Table 1:

[0048]

[0049]

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Abstract

The invention relates to the technical field of biology, in particular to a glioma prognosis marker CPVL and an application thereof. Thetechnical scheme includes: a glioma prognosis marker CPVLmRNA, the application of a reagent for detecting the expression amount of the marker CPVLmRNA in glioma tissues in preparing a glioma prognosis preparation; a glioma prognosis kit capable of detecting the content of the marker CPVLmRNA in glioma tissues, comprising PCR primers for detecting the content of the marker CPVLmRNA; and application of a glioma prognosis marker CPVLmRNA. The glioma prognosis marker CPVL and the application thereof can effectively verify that the CPVL knock-down can promote the apoptosis of glioma cells, inhibit the proliferation and the tumorigenesis of the glioma cells, regulate the cell cycle of the glioma, induce the apoptosis of the glioma cells by the CPVL knock-down, clarify the pathogenesis of the glioma and have important theoretical and practical meanings, and the oncogene CPVL plays an important role in the generation and development of the glioma, thereby providing a potential treatment target point for the treatment of the glioma.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a glioma prognostic marker CPVL and its application. Background technique [0002] Glioma is the most common intracranial malignant tumor clinically. Due to the influence of various physical, chemical, genetic and other factors, the incidence of glioma often ranks first in intracranial tumors, accounting for about 50% of brain tumors. Glioma has the characteristics of insidious onset, fast growth, easy invasion and metastasis, high fatality rate, and short average survival period. It has become a type of disease that causes great harm to human life and health. The current traditional therapies such as surgical resection, radiotherapy, and chemotherapy have not significantly improved the prognosis of patients with glioma, which has always been a major problem in the treatment of malignant tumors of the central nervous system. The fundamental reason is that the pathogenesis of glioma ...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/113
Inventor 吕坤杨辉李雪琴
Owner THE FIRST AFFILIATED HOSPITAL OF WANNAN MEDICAL COLLEGE YIJISHAN HOSPITAL OF WANNAN MEDICAL COLLEGE
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