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Preparing method and anti-ulcer application of nothopanax plant extracts and pharmaceutical composition thereof

A plant extract, extract technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., to achieve the effect of good anti-ulcer activity

Inactive Publication Date: 2019-05-31
DALI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no reports on the preparation method of the tea plant extract and the drug combination with the extract as the active ingredient, and its application in anti-ulcer at home and abroad.

Method used

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  • Preparing method and anti-ulcer application of nothopanax plant extracts and pharmaceutical composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of the tea plant extract of the genus Liangwang of the present invention:

[0021] Dry the whole plant of the genus Liangwang tea naturally, crush it to 30 mesh, and use 75% ethanol at 95 o Under the condition of C, reflux extraction was carried out 3 times, each time for 2 h, the extracts were combined, and the extracts were concentrated under reduced pressure to obtain the extract.

Embodiment 2

[0023] Anti-ulcer activity detection of the extract of the present invention:

[0024] SD rats were injected intraperitoneally with 1% pentobarbital sodium solution at a volume of 0.3 mL / 100 g. After anesthesia, 20 μL of 20% acetic acid solution was injected into the buccal mucosa of the rats. Then, a circular filter paper piece with a diameter of 5 mm completely soaked in 20% acetic acid solution was applied there for 60 s, and an ulcer formed after 24 h. After successful modeling, they were randomly divided into blank group (administered with normal saline), positive drug group (Guilin watermelon cream 0.6 g / kg) and Liangwang tea extract group (1.0 g / kg), with 5 rats in each group. Dosing once a day for 7 consecutive days. On the 8th day, the ulcer diameter of the rats was measured with a vernier caliper and the ulcer area was calculated.

[0025] The test results are shown in Table 1.

[0026]

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Abstract

The invention relates to a preparing method and anti-ulcer application of nothopanax plant extracts and a pharmaceutical composition thereof, and belongs to the field of the pharmacy of traditional Chinese medicines and natural medicines. The preparing method of an anti-ulcer medicine with the extracts as active components includes the steps of drying leaves or all of a nothopanax plant, smashingthe leaves or all of the nothopanax plant into 30 mesh, and conducting extraction with an organic solvent (chloroform or ethyl acetate or acetone or methyl alcohol or ethyl alcohol) or water. In the application of the nothopanax plant extracts to preparing an anti-ulcer agent, 0.01-30 g of nothopanax plant extracts are applied to a base material or a population and optionally combined with a carrier and / or a medium, and the good anti-ulcer activity is realized. The adaptation diseases of the nothopanax plant medicine are expanded, and the medicinal value of the nothopanax plant is improved.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine and natural medicine pharmacy, and in particular relates to a preparation method of an extract from the genus Lemongrass, a drug combination with the extract as an active ingredient, and its application in antiulcer agents. technical background: [0002] Liang Wang tea ( Nothopanax ) is an Araliaceae plant, an evergreen thornless tree or shrub with single or palmate compound leaves; it is mainly distributed in Oceania, and there are only two species in my country. Different leaf Liangwang tea[ Nothopanax davidii (Franch.) Harms ex Diels] distributed in Shaanxi, Hubei, Hunan, Sichuan, Guizhou, Yunnan and other places; born in sparse forests or positive shrub forests, forest edges, roadsides and rocky mountains, at altitudes in Hubei and Sichuan and Guizhou are usually distributed at 800-1800 meters, and in Yunnan it is as high as 2500-3000 meters. Palm leaf Liangwang tea [ N. dela...

Claims

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Application Information

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IPC IPC(8): A61K36/25A61P1/02A61K127/00
Inventor 姜北肖朝江王敏罗晓磊沈磊董相王开玲
Owner DALI UNIV
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