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Alpinia oxyphylla sugar polymer and preparation method and application thereof

A technology of sugar polymers and polymers, which is applied in drug combinations, nervous system diseases, etc., can solve problems that have not been reported, and achieve simple and convenient operation and significant effects

Active Publication Date: 2019-05-24
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, some scholars have studied the chemical components of Yizhiren, and found that Yizhiren contains sesquiterpenoids, flavonoids, volatile oils and polysaccharides. The research on the water extract of Yizhiren at home and abroad mainly focuses on Research on its anti-aging, anti-tumor, anti-oxidation, etc., but the research on the jellied jellied sugar polymer, refined sugar polymer and its prevention and treatment of neurodegenerative diseases and mental diseases has not been reported

Method used

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  • Alpinia oxyphylla sugar polymer and preparation method and application thereof
  • Alpinia oxyphylla sugar polymer and preparation method and application thereof
  • Alpinia oxyphylla sugar polymer and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Prepare the nootropic sugar polymer as follows:

[0050] 1) Material selection: Soak 24kg of dried and mature Yizhiren in water for 12 hours;

[0051] 2) Water extraction: extract the Yizhiren soaked in step 1) with 10 times the volume of hot water (100°C) for 2 hours, collect the extract and residue, and dry the residue;

[0052] 3) Fractional alcohol precipitation: Concentrate the extract obtained in step 2) at 60°C under reduced pressure, add ethanol for alcohol precipitation to make the volume concentration of ethanol 40%, leave it at room temperature for 24 hours, and then centrifuge to obtain supernatant 1 and precipitate 1, Collect the precipitate 1, which is the crude sugar polymer AO1; concentrate the supernatant 1 at 60°C under reduced pressure, add ethanol for alcohol precipitation to make the volume concentration of ethanol 60%, leave it at room temperature for 24 hours, and then centrifuge to obtain the supernatant 2 and precipitate 2 , the collected preci...

Embodiment 2

[0060] Prepare the nootropic sugar polymer as follows:

[0061] 1) Material selection: Soak 24kg of dried and mature Yizhiren in water for 6 hours;

[0062] 2) Water extraction: extract the Yizhiren soaked in step 1) with 5 times the volume of hot water (60°C) for 1 hour, collect the extract and residue, and dry the residue;

[0063] 3) Fractional alcohol precipitation: Concentrate the extract obtained in step 2) at 40°C under reduced pressure, add ethanol for alcohol precipitation to make the volume concentration of ethanol 10%, leave it at room temperature for 10 hours, and then centrifuge to obtain supernatant 1 and precipitate 1, Collect the precipitate 1, which is the crude sugar polymer AO1; concentrate the supernatant 1 at 40°C under reduced pressure, add ethanol for alcohol precipitation to make the volume concentration of ethanol 61%, leave it at room temperature for 10 hours, and then centrifuge to obtain the supernatant 2 and precipitate 2 , the collected precipita...

Embodiment 3

[0069]Prepare the nootropic sugar polymer as follows:

[0070] 1) Material selection: Soak 24kg of dried and mature Yizhiren in water for 10 hours;

[0071] 2) Water extraction: extract the Yizhiren soaked in step 1) with 15 times the volume of hot water (90°C) for 10 hours, collect the extract and residue, and dry the residue;

[0072] 3) Fractional alcohol precipitation: Concentrate the extract obtained in step 2) at 70°C under reduced pressure, add ethanol for alcohol precipitation so that the volume concentration of ethanol is 60%, leave it at room temperature for 28 hours, and then centrifuge to obtain supernatant 1 and precipitate 1, Collect the precipitate 1, which is the crude sugar polymer AO1; concentrate the supernatant 1 at 70°C under reduced pressure, add ethanol for alcohol precipitation to make the volume concentration of ethanol 80%, leave it at room temperature for 28 hours, and then centrifuge to obtain the supernatant 2 and precipitate 2 , the collected pre...

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Abstract

The invention provides a preparation method for an alpinia oxyphylla sugar polymer. The preparation method comprises the following steps of 1, material selection; 2, water extraction; 3, stage-by-stage alcohol precipitation; 4, alkaline extraction; 5, purification; 6, ion exchange column chromatography; 7, molecular sieve gel column chromatography. The invention further provides the alpinia oxyphylla sugar polymer prepared by using the preparation method and application of the alpinia oxyphylla sugar polymer. The alpinia oxyphylla sugar polymer is purified by using the method of the ion exchange chromatography and the molecular sieve gel column chromatography, and the alpinia oxyphylla sugar polymer which has not been reported previously is prepared. The physicochemical properties, the molecular weight, the monosaccharide compositions and the like of the sugar polymer are systematically analyzed and determined, and the feature structure of the sugar polymer is successfully obtained. The invention further provides activity study of the alpinia oxyphylla sugar polymer on the aspects of preventing a neurodegenerative disease and complications thereof and a mental disease and complications thereof.

Description

technical field [0001] The invention belongs to the technical fields of medicine, health care products and food, and relates to a method for preparing sugar polymers in plants, in particular to a method for preparing intelligence-enhancing brown sugar polymers and refined sugar polymers, and also relates to intelligence-enhancing coarse sugar polymers and Use of refined sugar polymers in the prevention and / or treatment of neurodegenerative diseases and their complications and psychiatric diseases and their complications. Background technique [0002] Neurodegenerative disease is an incurable malignant neurological disorder, its main feature is the degeneration and death of neurons in the central nervous system and peripheral nervous system, such neuron cells generally do not regenerate, As time goes by, the disease progresses gradually. Common neurodegenerative diseases include Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntingt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61P25/00A61P25/28
Inventor 严春艳施文婷张倩
Owner GUANGDONG PHARMA UNIV
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