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A plant-combined dressing that promotes regeneration of hair follicles in large-area wounds

A large-area, traumatic technology, applied in the field of medicine, can solve the problems of long regeneration process, high cost, long time, etc., and achieve the effect of increasing absorption, increasing absorption, and promoting hair follicle regeneration.

Active Publication Date: 2021-02-12
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Small and shallow injuries, due to the migration and proliferation of epidermal cells, can heal within a few days without forming scars; for larger and deeper injuries, the regeneration process takes a long time. After trauma, the first is blood coagulation and hemostasis, and inflammation occurs In response, numerous neutrophils enter the local area to remove bacteria; then many macrophages appear to remove damaged tissues, and release several bioactive substances to promote fibroblast proliferation and capillary growth to generate granulation tissue; granulation tissue is Delicate connective tissue, in which there are more fibroblasts and macrophages, less fibers, and rich capillaries; shortly after trauma, the epidermal cells around the wound proliferate and migrate to the wound surface, and the remaining sweat glands and hair follicle epithelium on the wound surface It can also proliferate, form epithelial islands covering the wound, and participate in epidermal regeneration. Finally, the wound is completely covered by the new epidermis, and gradually forms a normal epidermis, and the granulation tissue is gradually replaced by fibrous and dense connective tissue. Large (>5cm 2 ), the migration of epidermal cells is limited, and it is often necessary to transplant skin on the wound to cover the wound and assist in the repair and regeneration of skin hair follicles and other appendages to maintain skin function, but it takes a long time and costs a lot

Method used

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  • A plant-combined dressing that promotes regeneration of hair follicles in large-area wounds
  • A plant-combined dressing that promotes regeneration of hair follicles in large-area wounds
  • A plant-combined dressing that promotes regeneration of hair follicles in large-area wounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Based on the above-mentioned plant efficacy, adopt the technical scheme provided by the invention, weigh the following different parts by weight of pine needles, Agrimony, Arborvitae leaves, Burnet, Frankincense, natural borneol, as shown in Table 1, mix the weighed plants Grind into powder afterward, make lyophilized powder according to the prior art, and directly smear the powder on the wound surface.

[0031] The freeze-dried powder comparison table of plant weight part of table 1

[0032]

[0033] The freeze-dried powder formed from Experiment 1 to Experiment 15 in Table 1 was applied to 45 patients with extensive skin burns, and the patients were randomly divided into 15 groups, with 3 people in each group; Experiment 1 was used to treat patients in Group 1, and Experiment 2 It is used to treat the patients in the 2nd group, ... and so on. Experiment 15 is used to treat the patients in the 15th group. According to the observation of the recovery of the trauma, i...

Embodiment 2

[0035] In order to obtain a better freeze-dried powder, further experiments were carried out on the weight parts of pine needles, agrimony, arborvitae leaves, burnet, frankincense, and natural borneol in the freeze-dried powder, as shown in Table 2 for details.

[0036] Plant weight part experiment comparison table in table 2 freeze-dried powder

[0037]

[0038] The freeze-dried powder formed from Experiment 16 to Experiment 23 in Table 2 was used on 32 patients with extensive skin burns, and the patients were randomly divided into 8 groups with 4 people in each group; Experiment 16 was used to treat the first group of patients, and Experiment 17 For the treatment of the 2nd group of patients, ..., and so on, experiment 23 is used for the treatment of the 8th group of patients, according to the recovery situation of observing trauma, it is found that: the sum of the weight parts of pine needles and the weight parts of Agrimony, the weight parts of oriental cypress leaves, t...

Embodiment 3

[0040] Get the freeze-dried powder that the ratio of 10:8:3:1 of pine needles and Agrimony, Arborvitae leaves, Burnet and Frankincense and natural Borneol in Example 2 is made, according to the ratio of 3%, 5%, 8%, 10% The weight ratio is mixed with the alginate; then the mixture of the lyophilized powder and the alginate is cross-linked with chitosan to finally obtain the plant dressing, as shown in Table 3.

[0041] The dressing comparison table that the freeze-dried powder of different weight parts, alginate, chitosan are made of table 3

[0042]

[0043]

[0044]The formed dressing was applied to 36 patients with extensive burns on the skin, and the patients were randomly divided into 12 groups with 3 people in each group; experiment 24 was used to treat patients in group 1, experiment 25 was used to treat patients in group 2,..., By analogy, Experiment 35 was used to treat the 12th group of patients. After 14 days of treatment, it was found that when the mixing rati...

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Abstract

The present invention relates to a plant combination dressing that can promote the regeneration of large-area wounded hair follicles, comprising a fixed plant combination composed of pine needles, Agrimony, Arborvitae leaves, Burnet, frankincense and natural borneol, in parts by weight of pine needles and parts by weight of Agrimony sum, the weight portion of Arborvitae leaves, the weight portion of Burnet and the sum of the weight portion of Olibanum, the ratio of the weight portion of natural borneol is 10:8:3:1 when forming a lyophilized powder, and 8% of the frozen After the dry powder is mixed with lake algae, it is cross-linked with chitosan at a ratio of 1:20 to make a plant combination dressing. The invention can promote rapid healing of large-area wounds, has the effect of repairing and regenerating hair follicles at wounds, and is safe, economical and has no side effects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a plant combined dressing that can promote the regeneration of hair follicles in large-area wounds. Background technique [0002] After the skin is damaged, its regeneration process and repair time vary greatly depending on the damaged area and depth. Small and shallow injuries, due to the migration and proliferation of epidermal cells, can heal within a few days without forming scars; for larger and deeper injuries, the regeneration process takes a long time. After trauma, the first is blood coagulation and hemostasis, and inflammation occurs In response, numerous neutrophils enter the local area to remove bacteria; then many macrophages appear to remove damaged tissues, and release several bioactive substances to promote fibroblast proliferation and capillary growth to generate granulation tissue; granulation tissue is Delicate connective tissue, in which there are more fibrobl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00A61K36/739A61K9/06A61K47/36A61P17/02A61P17/00A61K31/045
Inventor 侯倩付小兵李美蓉朱姿英何文俊仲苓芝袁记方陈德云
Owner GENERAL HOSPITAL OF PLA
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