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Small-molecule inhibitor containing dihydracridine and application of inhibitor in inhibiting ornithine decarboxylase (ODC)

A small-molecule inhibitor, ornithine decarboxylase technology, applied in medical preparations containing active ingredients, organic active ingredients, organic chemistry, etc., can solve the problems of large toxic and side effects, high concentration of action, weak binding ability, etc.

Active Publication Date: 2019-05-21
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its binding ability to ODC is weak, and its concentration is very high, and because it is a suicide inhibitor that forms a covalent bond with ODC, its toxic and side effects are very large

Method used

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  • Small-molecule inhibitor containing dihydracridine and application of inhibitor in inhibiting ornithine decarboxylase (ODC)
  • Small-molecule inhibitor containing dihydracridine and application of inhibitor in inhibiting ornithine decarboxylase (ODC)
  • Small-molecule inhibitor containing dihydracridine and application of inhibitor in inhibiting ornithine decarboxylase (ODC)

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Embodiment 1

[0037] The involved dihydroacridine-containing small molecule inhibitor is: 2,2-dimethyl-N-(6-methyl-4-oxo-3,4-dihydro-2-acridinyl)propionamide , the structural formula is shown in the figure.

[0038]

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PUM

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Abstract

The invention provides a small-molecule inhibitor containing dihydracridine. The small-molecule inhibitor is 2, 2-dimethyl-N-(6-methyl-4-oxo-3, 4-dihydro-2-acridinyl) propanamide. The structural formula of the inhibitor is shown in the description. The small-molecule inhibitor containing the dihydracridine is applied to inhibiting the ornithine decarboxylase (ODC) and preparing medicine used for treating tumors and medicine used for treating pathogenic microorganism infection, and significant effects are achieved.

Description

technical field [0001] The invention relates to a small-molecule inhibitor of ornithine decarboxylase (Ornithine decarboxylase; ODC) and its application, in particular to a small-molecule inhibitor of human ornithine decarboxylase and its application in inhibiting and killing tumor cells. Background technique [0002] Protein is one of the main components of organisms and the main substance to complete various life activities. Among various proteins, proteases are crucial to life activities, and almost all biochemical reactions in organisms are catalyzed by proteases. The activity of various proteases in organisms has a strict regulation mechanism. Once there is a problem with the regulation mechanism, the activity of proteases is too high, too low or completely inactivated, which will cause various diseases. Therefore, it has very important theoretical and practical significance to regulate the activity of protease by drugs to restore and maintain it at a normal level. St...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D475/04A61K31/519A61P31/00A61P35/00
Inventor 刘森苏正定黄永棋占景琼柴晓颖潘静成细瑶
Owner HUBEI UNIV OF TECH
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