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Detection method of viscosity of colloidal bismuth pectin or colloidal bismuth pectin containing preparation

A colloidal bismuth pectin and detection method technology, applied in the direction of measuring devices, flow characteristics, instruments, etc., can solve the problems of large error in measurement results, long detection time, cumbersome operation, etc., to ensure the effectiveness, and the detection method is simple and fast , accurate results

Inactive Publication Date: 2019-05-07
SHANXI ZHENDONG ANTE BIOPHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The above-mentioned intrinsic viscosity detection method not only has many experimental steps, cumbersome operation, and long detection time, but also requires high proficiency in the operation of the experimenter, and the error of the measurement result is relatively large.

Method used

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  • Detection method of viscosity of colloidal bismuth pectin or colloidal bismuth pectin containing preparation
  • Detection method of viscosity of colloidal bismuth pectin or colloidal bismuth pectin containing preparation
  • Detection method of viscosity of colloidal bismuth pectin or colloidal bismuth pectin containing preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: Measuring the dynamic viscosity of colloidal bismuth pectin bulk drug.

[0029] Take 3.0g of colloidal bismuth pectin raw material, put it in a beaker, add 100ml of water, stir to disperse, add 400ml of artificial gastric juice (10000 units of pepsin activity), stir evenly, and fix the beaker vertically in a constant temperature water bath at 20°C±0.1°C After standing for 15 minutes, the determination was carried out according to the third method of the 0633 viscosity determination method in the "Chinese Pharmacopoeia" 2015 edition of the four general rules, and the measured dynamic viscosity was 279.85mPa·s.

Embodiment 2

[0030] Embodiment 2: Measuring the dynamic viscosity of colloidal bismuth pectin capsules (specification 40 mg, calculated as bismuth).

[0031] Take 4.0g of colloidal bismuth pectin capsules, put them in a beaker, add 200ml of water, stir to disperse, add 300ml of artificial gastric juice (12000 units of pepsin activity), stir evenly, and fix the beaker vertically in a constant temperature water bath at 25°C±0.1°C, After standing for 15 minutes, measure according to the third method of rotational viscometer in the 0633 viscosity determination method in the four general rules of the "Chinese Pharmacopoeia" 2015 edition, and the measured dynamic viscosity is 250.51mPa·s.

Embodiment 3

[0032] Embodiment 3: Determination of the dynamic viscosity of colloidal pectin bismuth capsules (specification 50 mg, calculated as bismuth).

[0033] Take 5.0g of colloidal bismuth pectin capsules, put them in a beaker, add 150ml of water, stir to disperse, add 350ml of artificial gastric juice (pepsin activity 15,000 units), stir evenly, and fix the beaker vertically in a constant temperature water bath at 25°C±0.1°C, After standing for 15 minutes, the determination was carried out according to the third method of the 0633 viscosity determination method in the "Chinese Pharmacopoeia" 2015 Edition Four General Rules, and the measured dynamic viscosity was 478.90 mPa·s.

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Abstract

The invention discloses a detection method of viscosity of colloidal bismuth pectin or a colloidal bismuth pectin containing preparation. The colloidal bismuth pectin or the colloidal bismuth pectin containing preparation is dispersed with a proper amount of water and added with artificial gastric juice to form stable sol with high viscosity, and the dynamic viscosity of the sol is measured according to a third-method rotary viscosimeter measurement method of the 0633 viscosity measurement method in the four-part general rule of (the Chinese pharmacopoeia) 2015. The method in the invention issimple, convenient and rapid, and accurate in result, the dynamic viscosity is measured in the human body gastrointestinal environment, so that the viscosity situation of the colloidal bismuth pectinin a human body can be better embodied so as to reflect the colloid characteristics of the colloidal bismuth pectin or the colloidal bismuth pectin containing preparation.

Description

technical field [0001] The invention belongs to the technical field of colloidal pectin bismuth quality control, and relates to a viscosity detection method of colloidal pectin bismuth or a preparation containing colloidal pectin bismuth. Background technique [0002] Colloidal bismuth pectin and its capsules are the first drugs produced by Taiyuan Hongxing Pharmaceutical Factory, the predecessor of Shanxi Zhendong Ante Biopharmaceutical Co., Ltd. The drug was first approved by the former Ministry of Health in July 1992 to be produced and launched by Taiyuan Hongxing Pharmaceutical Factory. [0003] Colloidal bismuth pectin is a protective agent for gastric mucosa, which has the functions of protecting gastrointestinal mucosa, killing Helicobacter pylori and hemostasis. It can promote ulcer healing, improve inflammation, and reduce the recurrence rate of ulcers. Its mechanism of action is based on the strong colloidal properties of colloidal bismuth pectin. It forms a high-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N11/14
Inventor 李安平李娜朱平李昆高荣华高宁刘艳之
Owner SHANXI ZHENDONG ANTE BIOPHARMACEUTICAL CO LTD
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