Blood purifying substitution fluid
A technology of blood purification and replacement fluid, which is applied in the direction of blood diseases, extracellular fluid diseases, active ingredients of alkali/alkaline earth metal chlorides, etc., and can solve the problems of patients with lactic acidosis, unable to meet the needs, and complex volume calculations. , to avoid lactic acidosis, facilitate treatment, and stabilize the internal environment of the body
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Embodiment 1
[0017] The replacement solution was prepared with 0.9% sodium chloride solution, 10% potassium chloride injection, 5% sodium bicarbonate injection, 25% magnesium sulfate injection and 5% glucose injection, with a volume of 3L.
[0018] Among them, the concentration of sodium chloride in the blood purification replacement fluid is 135mmol / L, and the volume of sodium chloride injection is 2.0L. According to the application characteristics of a large number of replacement fluids for blood purification, the most basic components of the liquid used in blood purification are retained, suitable for It can be used in large-scale production and application; it can form a good replacement carrier fluid similar to normal saline commonly used in clinical practice in blood purification treatment. Based on a blood purification and replacement solution in the above concentration range, different blood purification and replacement solutions can be configured, so that patients can obtain better...
Embodiment 2
[0025] The replacement solution is prepared with 0.9% sodium chloride solution, 10% potassium chloride injection, 5% sodium bicarbonate injection, 25% magnesium sulfate injection and 5% glucose injection, with a total volume of 3L.
[0026] After adding magnesium sulfate, the concentration of magnesium sulfate in the replacement solution is 0.75mmol / L, and the volume of magnesium sulfate injection is 0.7mL.
[0027] Preferably, the concentration of sodium bicarbonate in a blood purification replacement fluid is 35mmol / L, and the volume is 180mL;
[0028] Preferably, the concentration of the potassium chloride solution is 4mmol / L, and the volume of potassium chloride injection is 9mL;
[0029] Preferably, the concentration of calcium chloride in the blood purification replacement solution is 1.75mmol / L, and the volume is 9mL; 22g sodium bicarbonate is added to 6000mL water for injection to prepare a blood purification replacement solution, and at the same time Add 0.8 g of mag...
Embodiment 3
[0031] 22g sodium chloride is added in 2800mL water for injection to prepare a kind of blood purification replacement fluid, simultaneously in a kind of blood purification replacement fluid, add magnesium sulfate 0.72g and calcium chloride 0.9g. Afterwards, according to the conventional preparation method of large infusion solution, after stirring, preliminary filtration, and then terminal filtration, it is filled in a medical plastic infusion bag, sealed, and sterilized to obtain a hypertonic blood purification replacement solution.
[0032] For patients with normal blood sugar, glucose can be added to the above-mentioned various sugar-free blood purification replacement fluids to achieve the function of supplementing sugar for patients. After adding glucose, the concentration of glucose in the blood purification replacement fluid is 5.5 mol / L.
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