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Blood purifying substitution fluid

A technology of blood purification and replacement fluid, which is applied in the direction of blood diseases, extracellular fluid diseases, active ingredients of alkali/alkaline earth metal chlorides, etc., and can solve the problems of patients with lactic acidosis, unable to meet the needs, and complex volume calculations. , to avoid lactic acidosis, facilitate treatment, and stabilize the internal environment of the body

Inactive Publication Date: 2019-04-23
文明祥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the most commonly used blood purification replacement fluid is a lactate solution composed of sodium, potassium, calcium, magnesium and glucose, but the potassium, glucose and lactate contained in the lactate solution are not It is suitable for critically ill patients whose metabolites are acidic or whose blood sugar and blood potassium have been significantly increased, especially for patients whose liver function has been damaged. This kind of blood purification replacement fluid will cause lactic acidosis and aggravate the condition of patients
Because renal failure and critically ill patients are often in an unstable metabolic state (including acidosis, hyperglycemia, hyperkalemia, hypercatabolism, and lactic acidosis), the existing finished product, a blood purification replacement fluid, cannot meet needs
In order to meet such critically ill patients, some hospitals will prepare replacement fluids of different volumes for patients according to the different needs of different patients. It is cumbersome and brings a lot of uncertainty to clinical work

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The replacement solution was prepared with 0.9% sodium chloride solution, 10% potassium chloride injection, 5% sodium bicarbonate injection, 25% magnesium sulfate injection and 5% glucose injection, with a volume of 3L.

[0018] Among them, the concentration of sodium chloride in the blood purification replacement fluid is 135mmol / L, and the volume of sodium chloride injection is 2.0L. According to the application characteristics of a large number of replacement fluids for blood purification, the most basic components of the liquid used in blood purification are retained, suitable for It can be used in large-scale production and application; it can form a good replacement carrier fluid similar to normal saline commonly used in clinical practice in blood purification treatment. Based on a blood purification and replacement solution in the above concentration range, different blood purification and replacement solutions can be configured, so that patients can obtain better...

Embodiment 2

[0025] The replacement solution is prepared with 0.9% sodium chloride solution, 10% potassium chloride injection, 5% sodium bicarbonate injection, 25% magnesium sulfate injection and 5% glucose injection, with a total volume of 3L.

[0026] After adding magnesium sulfate, the concentration of magnesium sulfate in the replacement solution is 0.75mmol / L, and the volume of magnesium sulfate injection is 0.7mL.

[0027] Preferably, the concentration of sodium bicarbonate in a blood purification replacement fluid is 35mmol / L, and the volume is 180mL;

[0028] Preferably, the concentration of the potassium chloride solution is 4mmol / L, and the volume of potassium chloride injection is 9mL;

[0029] Preferably, the concentration of calcium chloride in the blood purification replacement solution is 1.75mmol / L, and the volume is 9mL; 22g sodium bicarbonate is added to 6000mL water for injection to prepare a blood purification replacement solution, and at the same time Add 0.8 g of mag...

Embodiment 3

[0031] 22g sodium chloride is added in 2800mL water for injection to prepare a kind of blood purification replacement fluid, simultaneously in a kind of blood purification replacement fluid, add magnesium sulfate 0.72g and calcium chloride 0.9g. Afterwards, according to the conventional preparation method of large infusion solution, after stirring, preliminary filtration, and then terminal filtration, it is filled in a medical plastic infusion bag, sealed, and sterilized to obtain a hypertonic blood purification replacement solution.

[0032] For patients with normal blood sugar, glucose can be added to the above-mentioned various sugar-free blood purification replacement fluids to achieve the function of supplementing sugar for patients. After adding glucose, the concentration of glucose in the blood purification replacement fluid is 5.5 mol / L.

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Abstract

The invention discloses blood purifying substitution fluid which comprises injection water, 0.9% of sodium chloride, 25% of magnesium sulfate, 25% of glucose, 5% of sodium bicarbonate, 10% of potassium chloride and 5% of calcium chloride. Various acute and chronic renal failure patients and critical patients can be subjected to continuous blood purifying treatment, and the defects of existing unequal and dazzling capacity, complicated capacity calculating and the like are overcome; meanwhile, the difficulty that bicarbonate and calcium salt cannot be mixed on clinic is overcome, the lactic acidosis, hyperglycemia, hyperkalemia and other complications of the patients can be effectively avoided, the in-vivo environment of the patients can be stabilized to the maximum extent, the burdens on medical staff are relieved, the treatment of diseases is facilitated, individualized configuration can be conducted according to different physiological statuses and requirements of the patients, the hyperkalemia, lactic acidosis, hyperglycemia and other complications can be effectively avoided, and the in-vivo environment of the patients is stabilized to the maximum extent. Meanwhile, the blood purifying substitution fluid is simple in configuration, safe and free of risks.

Description

technical field [0001] The invention belongs to the technical field of medicine manufacture, and in particular relates to a blood purification replacement fluid. Background technique [0002] In recent years, in the continuous blood purification technology, a blood purification replacement fluid has played a vital role. On the one hand, it can be used as a carrier to remove waste substances, and remove metabolites and poisons in the body; on the other hand, It can supplement the substances lacking in the body, such as bicarbonate, potassium salt, etc., to maintain the patient's internal environment in a stable state. At present, the most commonly used blood purification replacement fluid is a lactate solution composed of sodium, potassium, calcium, magnesium and glucose, but the potassium, glucose and lactate contained in the lactate solution are not It is suitable for critically ill patients whose metabolites are acidic or whose blood sugar and potassium have been signific...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61P7/08A61P13/12A61P3/12A61K33/06A61K31/7004A61K33/00
CPCA61K31/7004A61K33/00A61K33/06A61K33/14A61K2300/00
Inventor 文明祥瞿祥朱严严
Owner 文明祥
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