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Acupoint injection for treating cerebral infarction and application thereof

An injection, cerebral infarction technology, applied in the field of medicine

Inactive Publication Date: 2021-07-06
谢芳萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Acupoint injection for treating cerebral infarction and application thereof
  • Acupoint injection for treating cerebral infarction and application thereof
  • Acupoint injection for treating cerebral infarction and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Acupoint Injection Emulsion

[0030]

[0031] Preparation:

[0032] Mix the prescribed amount of repaglinide, cilostazol and soybean oil, heat and stir to form an oil phase, the stirring speed is 4000 rpm, the stirring time is 15 minutes, and the temperature is maintained at 60°C;

[0033] Dissolve the prescribed amount of glycerin, egg yolk lecithin, and poloxamer 188 in water for injection, heat and stir to form a water phase, the stirring speed is 4000 rpm, the stirring time is 10 minutes, and the temperature is maintained at 60°C;

[0034] Slowly add the oil phase into the water phase dropwise, mix while stirring at 6000 rpm, continue stirring for 10 minutes after mixing, add the remaining amount of water for injection to dilute to obtain colostrum;

[0035] Pass the colostrum through a 0.8-micron microporous membrane, emulsify it with a homogenizer, pass through a 0.22-micron microporous membrane, and pack it separately.

Embodiment 2

[0036] Example 2 Acupoint Injection Emulsion

[0037]

[0038] Preparation:

[0039] Mix the prescribed amount of repaglinide, cilostazol and soybean oil, heat and stir to form an oil phase, the stirring speed is 4000 rpm, the stirring time is 20 minutes, and the temperature is maintained at 70°C;

[0040] Dissolve the prescribed amount of glycerin, egg yolk lecithin, and poloxamer 188 in water for injection, heat and stir to form a water phase, the stirring speed is 4000 rpm, the stirring time is 10 minutes, and the temperature is maintained at 70°C;

[0041] Slowly add the oil phase to the water phase dropwise, mix while stirring at 6000 rpm, continue stirring for 10 minutes after mixing, add the remaining amount of water for injection to dilute to obtain colostrum;

[0042] Pass the colostrum through a 0.8-micron microporous membrane, emulsify it with a homogenizer, pass through a 0.22-micron microporous membrane, and pack it separately.

Embodiment 3

[0043] Example 3 Acupoint Injection Emulsion

[0044]

[0045] Preparation:

[0046] Mix the prescribed amount of repaglinide, cilostazol and soybean oil, heat and stir to form an oil phase, the stirring speed is 4000 rpm, the stirring time is 30 minutes, and the temperature is maintained at 60°C;

[0047] Dissolve the prescribed amount of glycerin, egg yolk lecithin, and poloxamer 188 in water for injection, heat and stir to form a water phase, the stirring speed is 4000 rpm, the stirring time is 10 minutes, and the temperature is maintained at 60°C;

[0048] Slowly add the oil phase into the water phase dropwise, mix while stirring at 6000 rpm, continue stirring for 10 minutes after mixing, add the remaining amount of water for injection to dilute to obtain colostrum;

[0049] Pass the colostrum through a 0.8-micron microporous membrane, emulsify it with a homogenizer, pass through a 0.22-micron microporous membrane, and pack it separately.

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Abstract

The invention relates to the field of medicine, in particular to an acupoint injection for treating cerebral infarction and its application. The active ingredients of the acupoint injection are repaglinide and cilostazol, wherein the weight ratio of repaglinide and cilostazol is 1:20-1:40. The acupoint injection is preferably fat emulsion, and the preferred pharmaceutical excipients are glycerin, lecithin, soybean oil, poloxamer 188 and water for injection. The acupoint injection has the effect of improving the infarct size and nerve score of the experimental animal model when administered through the acupoint injection route, and has the potential to be used for the treatment of cerebral infarction.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an acupoint injection for treating cerebral infarction and its application. Background technique [0002] Cerebral infarction is a brain disease caused by blocking microcirculation after cerebrovascular thrombosis. Cerebral ischemia hypoxia and edema will further lead to nerve damage, which will lead to a decrease in the patient's neurological function, which can easily lead to hemiplegia. The incidence rate of cerebral infarction in my country is about 0.219%, among which the incidence rate of the elderly population is higher, and the disability rate is 75.0%. Therefore, cerebral infarction is a fatal and disabling disease that seriously affects the health of middle-aged and elderly people. Hemiplegia caused by cerebral infarction also increases the burden of family care and public expenditure on social health. [0003] Thrombolysis is the main treatment for acute cerebral...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K47/24A61K31/451A61K31/4709A61P9/10
CPCA61K9/0019A61K9/08A61K31/451A61K31/4709A61K47/24A61P9/10A61K2300/00
Inventor 谢芳萍张惊宇袁媛
Owner 谢芳萍
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