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Colorectal cancer diagnostic markers and colorectal cancer detection products and their applications

A diagnostic marker, colorectal cancer technology, applied in the field of medicine, can solve the problem of inconvenient detection of disease progress for patients, and achieve high sensitivity and strong specificity

Active Publication Date: 2022-02-15
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Ulcerative colitis and inflammatory bowel polyps are often regarded as one of the high-risk factors for colorectal cancer. Colonoscopy detection and re-examination are invasive examinations, and it is very inconvenient for patients to detect disease progression

Method used

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  • Colorectal cancer diagnostic markers and colorectal cancer detection products and their applications

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Embodiment

[0031] Peripheral blood serum sample collection method: collect 10mL peripheral blood venous sample in the morning on an empty stomach, let it stand at room temperature for two hours, centrifuge at 1000g at 4°C for 15min, separate the upper layer of plasma, and store it at -80°C for later use.

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Abstract

The invention relates to a colorectal cancer diagnostic marker, a colorectal cancer detection product and an application thereof. The colorectal cancer diagnostic marker includes multiple secreted proteins, and the multiple secreted proteins include one or two of S100A9 protein and tenascin-c protein, and CEA protein. With the characteristics of high sensitivity and strong specificity, the area under the ROC curve of the diagnostic model is 0.902, and the reliability of the diagnostic result is much higher than that of a single protein marker, which is of great significance for the diagnosis and treatment of colorectal cancer. The colorectal cancer detection product includes the above-mentioned colorectal diagnostic markers. The present invention also proposes the application of colorectal diagnostic markers in the preparation of products for auxiliary diagnosis of colorectal cancer.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a colorectal cancer diagnostic marker, a colorectal cancer detection product and an application thereof. Background technique [0002] Colorectal cancer is one of the most common malignant tumors of the digestive tract in the world. In the past 20 years, the incidence and mortality of colon cancer have been on the rise in most countries in the world. Most colon cancer patients are found to be in the late stage, and the prognosis poor. The current screening and diagnosis methods for colon cancer are invasive, and colonoscopy is still the gold standard for its screening and diagnosis. In recent years, fecal occult blood test is the most commonly used non-invasive test method in colorectal cancer screening, but its sensitivity and specificity are low. If simple serum detection can be applied to its early diagnosis, it will contribute to the prevention and prognosis of colon cance...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574G01N33/68
CPCG01N33/574G01N33/57419G01N33/57446G01N33/57484G01N33/6893G01N2800/065G01N2333/4746
Inventor 陈永恒周敏泽李茂玉陈主初
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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