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Glycocholic acid immunoturbidimetric assay kit

A detection kit and immunoturbidimetric technology, which are applied in the direction of measuring devices, material analysis by observing the influence on chemical indicators, instruments, etc., can solve the problems of low sensitivity, limited popularization and application, poor stability of detection reagents, etc. problems, to achieve the effect of improving analytical sensitivity and enhancing stability

Inactive Publication Date: 2019-04-02
BIOBASE BIODUSTRY (SHANDONG) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the common glycocholic acid immunoturbidimetric assay reagent has poor stability and low sensitivity, which limits its clinical application.

Method used

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  • Glycocholic acid immunoturbidimetric assay kit
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  • Glycocholic acid immunoturbidimetric assay kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A glycocholic acid immune turbidimetric detection kit comprises reagent R1, reagent R2 and calibration products.

[0039] Wherein the reagent R1 consists of:

[0040]

[0041] Reagent R2 consists of:

[0042]

[0043] The specific measurement method is the same as in Comparative Example 1.

Embodiment 2

[0045] A glycocholic acid immune turbidimetric detection kit comprises reagent R1, reagent R2 and calibration products.

[0046] Wherein the reagent R1 consists of:

[0047]

[0048]

[0049] Reagent R2 consists of:

[0050]

[0051] The specific measurement method is the same as in Comparative Example 1.

[0052] Experimental verification was carried out on the analytical performance of the kits prepared in the above comparative examples and examples.

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Abstract

The invention discloses a glycocholic acid immunoturbidimetric assay kit, and belongs to the technical field of clinical in vitro detection reagents. The kit of the present invention comprises a reagent R1, a reagent R2, and a calibrator. The Glycocholic acid immunoturbidimetric assay kit improves the stability and analytical sensitivity of the kit by adding a certain amount of silica-coated magnetic nanoparticles to reagent R1 and adding a certain amount of bovine serum albumin and Kathon CG to reagent R2, and the accuracy of the reagent is high, which is favorable for further promotion in the market.

Description

technical field [0001] The invention relates to the technical field of clinical in vitro detection reagents, in particular to a glycocholic acid immune turbidimetric detection kit. Background technique [0002] Serum Cholyglycine (CG) is one of the conjugated bile acids formed by the combination of bile acid and glycine. In liver cells, cholesterol is transformed into primary bile acid through complex enzymatic reactions. Among them are cholic acid (CA) and chenodeoxycholic acid (CD-CA). There are three hydroxyl groups (C3, C7, C12) on the steroid core of cholic acid, and the hydroxyl group at the end of the side chain is combined with glycine through a peptide bond, with a molecular weight of 462u. [0003] When the liver cells are damaged, the ability of the liver cells to absorb CG decreases, resulting in an increase in the content of CG in the blood. In cholestasis, the hepatic excretion of bile acid is hindered, and the CG content of the reflux blood circulation incre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/543G01N21/82
CPCG01N21/82G01N33/54326G01N33/54346
Inventor 甘宜梧李静王美丽
Owner BIOBASE BIODUSTRY (SHANDONG) CO LTD
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