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Inhalation preparation and preparation method and application thereof

A technology for inhalation preparations and regulators, which is applied in the fields of pharmaceutical formulations, aerosol delivery, respiratory diseases, etc. It can solve the problems of low utilization rate, slow onset of action, and inability to directly act on the patient's part to achieve good atomization effect , high absorption rate, avoiding the effect of significantly reducing the content of volatile components

Active Publication Date: 2019-03-26
GUANGZHOU XIANGXUE PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional oral preparations generally have the problems of large doses, inability to directly act on the affected part, slow onset of action, low utilization rate, and accompanied by adverse reactions in the gastrointestinal tract

Method used

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  • Inhalation preparation and preparation method and application thereof
  • Inhalation preparation and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037]This embodiment provides a kind of Huajuhong atomized inhalation and its preparation method, specifically as follows:

[0038] (1) Take 200 g of Huajuhong, add 8 times the amount of water, heat and decoct for 2 hours, collect volatile oil and non-volatile extraction products, filter the non-volatile extraction products, and obtain extract A and medicinal residues;

[0039] (2) adding 6 times the amount of water to the dregs, heating and decocting for 2 hours, and filtering to obtain the extract B;

[0040] (3) Combine the extract A and extract B obtained in steps (1) and (2), reclaim ethanol and concentrate to an appropriate amount, add ethanol to make the alcohol content reach 70%, stir well, let stand, and take the supernatant for recovery Ethanol and concentrated to obtain the orange extract;

[0041] (4) Take the volatile oil of step (1) and add hydroxypropyl-β-cyclodextrin with an average substitution degree of 4.5 for clathrate, to obtain the inclusion liquid, whe...

Embodiment 2

[0044] This embodiment provides a kind of Huajuhong atomized inhalation and its preparation method, specifically as follows:

[0045] (1) Take 200 g of Huajuhong, add 8 times the amount of water, heat and decoct for 2 hours, collect volatile oil and non-volatile extraction products, filter the non-volatile extraction products, and obtain extract A and medicinal residues;

[0046] (2) adding 6 times the amount of water to the dregs, heating and decocting for 2 hours, and filtering to obtain the extract B;

[0047] (3) Combine the extract A and extract B obtained in steps (1) and (2), reclaim ethanol and concentrate to an appropriate amount, add ethanol to make the alcohol content reach 70%, stir well, let stand, and take the supernatant for recovery Ethanol and concentrated to obtain the orange extract;

[0048] (4) The volatile oil in step (1) is added to hydroxypropyl-β-cyclodextrin with an average degree of substitution of 4.5 for clathrate to obtain clathrate liquid, where...

Embodiment 3

[0051] This embodiment provides a kind of Huajuhong atomized inhalation and its preparation method, specifically as follows:

[0052] (1) Take 200 g of Huajuhong, add 8 times the amount of water, heat and decoct for 2 hours, collect volatile oil and non-volatile extraction products, filter the non-volatile extraction products, and obtain extract A and medicinal residues;

[0053] (2) adding 6 times the amount of water to the dregs, heating and decocting for 2 hours, and filtering to obtain the extract B;

[0054] (3) Combine the extract A and extract B obtained in steps (1) and (2), reclaim ethanol and concentrate to an appropriate amount, add ethanol to make the alcohol content reach 70%, stir well, let stand, and take the supernatant for recovery Ethanol and concentrated to obtain the orange extract;

[0055] (4) Take the volatile oil of step (1) and add hydroxypropyl-β-cyclodextrin with an average substitution degree of 10.0 for clathrate, to obtain the inclusion liquid, w...

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Abstract

The invention provides an inhalation preparation and a preparation method and application thereof. The inhalation preparation is prepared from an active component, namely a pummelo peel extract and apharmaceutic adjuvant suitable for inhalation administration; the pummelo peel extract is a pummelo peel extracting solution or a mixture of pummelo peel volatile oil and the pummelo peel extracting solution or a mixture of pummelo peel distillate and the pummelo peel extracting solution; the pummelo peel extract contained in every 100 ml of inhalation preparation is prepared from 10-60 g of pummelo peel; and the pH value of the inhalation preparation is regulated to 4.0-8.5 through a pH regulating agent. The pummelo peel extracting solution and the pummelo peel volatile oil or the pummelo peel distillate serve as the active component, after the volatile oil or the distillate is subjected to clathration by cyclodextrin, the acidity or alkalinity is regulated to the appropriate concentration through cooperation, and finally uniformity and stability of the atomized inhalation preparation of the pummelo peel are ensured.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an inhalation preparation and its preparation method and application. Background technique [0002] Respiratory system diseases are common and frequently-occurring diseases, common typical symptoms: cough, phlegm, wheezing. Affected by factors such as increasingly serious air pollution, increasing number of smokers, and population aging, the incidence and mortality of various respiratory diseases are increasing. In recent years, smog has swept across most parts of our country, and its harm to the human body is self-evident, and the first to bear the brunt is the human respiratory system and cardiovascular fields. [0003] Inhalation preparations refer to preparations in which the drug is dissolved or dispersed in a suitable medium and delivered to the respiratory tract or lungs in the form of steam or aerosol to exert local or systemic effects. Compared with...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K9/72A61K47/69A61P11/06A61P11/10A61P11/14A61K131/00
CPCA61K9/0073A61K36/752A61K47/6951A61P11/06A61P11/10A61P11/14A61K2300/00
Inventor 黄洁文王艳慧江晓杨丽莹吴舒楹曾仑王永辉
Owner GUANGZHOU XIANGXUE PHARMA CO LTD
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