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Method for accurately positioning and correcting abnormal brain region based on functional magnetic resonance imaging

A technology of functional magnetic resonance and precise positioning, which is applied in the field of medical image processing and application, and can solve problems such as difficulties in the evaluation and treatment of brain diseases, unsatisfactory results, and lack of identification methods for abnormal brain regions.

Inactive Publication Date: 2019-03-19
FUDAN UNIV
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Problems solved by technology

Clinical studies have shown that the current intervention targets of rTMS in the treatment of depression are relatively fixed, such as the left and right dorsolateral prefrontal cortex, but due to individual differences or the specificity of patient lesions, the effect of rTMS treatment is not satisfactory; In the detection and treatment of diseases, there is still a lack of identification methods for abnormal brain regions at the individual level, which brings certain difficulties to the assessment and treatment of brain diseases

Method used

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  • Method for accurately positioning and correcting abnormal brain region based on functional magnetic resonance imaging
  • Method for accurately positioning and correcting abnormal brain region based on functional magnetic resonance imaging
  • Method for accurately positioning and correcting abnormal brain region based on functional magnetic resonance imaging

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Embodiment 1 clinical research experiment

[0021] Select suitable patients with depression for precise positioning and correction of abnormal brain regions of functional magnetic resonance imaging,

[0022] fMRI detection reference parameters:

[0023] High-resolution T1-weighted structural imaging (T1-weighted): echo time (TE) 2.52 milliseconds; repetition time (TR) 1900 milliseconds; inversion time (TI) 900 milliseconds; inversion angle 9 degrees; slice 176; thickness 1 mm; resolution 256×256, voxel size 1×1×1 cubic millimeter;

[0024] Functional imaging: echo time (TE) 30 ms; repetition time (TR) 2000 ms; inversion time (TI) 900 ms; inversion angle 90 degrees; slice 32; slice thickness 3 mm; slice interval 1 mm; resolution 64 x 64, voxel size 3 x 3 x 3 mm3.

[0025] rs-fMRI imaging preprocessing:

[0026] 1) Slicing timing: through the interpolation method, the error caused by the time difference of different brain slice acquisitions is eliminated;

[0027] 2)...

Embodiment 2

[0060] According to the method of Example 1 above, select suitable patients with schizophrenia for precise positioning and correction of abnormal brain regions of functional magnetic resonance imaging,

[0061] The experimental results showed that in the tested schizophrenia patients: weakened medial frontal lobe-cerebellum connections, and enhanced connections between the inferior frontal gyrus, medial temporal gyrus, and cerebellum; enhanced and weakened internal frontal lobe connections; enhanced cerebellum and Motor cortex connectivity and enhanced thalamo-motor cortex connectivity, as well as weakened thalamo-cerebellar connectivity, could use the obtained target regions to develop interventions for this psychiatric disorder for clinical use of rTMS.

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Abstract

The invention belongs to the field of medical image processing and application, and relates to a method for accurately positioning and correcting an abnormal brain region based on a functional magnetic resonance imaging, in particular to a method for calculating inter-brain activity correlation based on a functional magnetic resonance imaging signal. The method for accurately positioning and correcting the abnormal brain region based on the functional magnetic resonance imaging comprises the following step of accurately detecting and calculating the activity correlation between any brain regions of the whole brain of a subject, namely the whole brain functional connection (FC) by using a resting state functional magnetic resonance technology (rs-fMRI). The method can provide medical basisfor the detection of individual brain function connection and the study of group on the integration of mass data for various brain diseases including depression, and provide objective basis for the evaluation of individual physiological and psychological health level. The method can be further used for determining the target area of the rTMS intervention and facilitating accurate intervention aiming at the target area of an individual by using the rTMS, and formulating intervention measures of mental diseases such as depression and the like by using the rTMS clinically.

Description

technical field [0001] The invention belongs to the field of medical image processing and application, and relates to a method for precise positioning and correction of abnormal brain regions based on functional magnetic resonance imaging; in particular, it relates to a method for calculating the correlation of brain interval activities based on functional magnetic resonance imaging signals, and in particular to a method based on functional magnetic resonance imaging. A Method for Computing Correlations of Brain Interval Activity in Depression from Magnetic Resonance Imaging Signals. The method of the present invention includes the combination of nuclear magnetic resonance apparatus and various parameters of transcranial magnetic stimulation treatment and the connection algorithm of the whole brain function variation, and accurately implements repetitive transcranial magnetic stimulation (rTMS) to intervene in brain region activities, which will provide rTMS stimulation for dep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055A61N2/00
CPCA61B5/055A61N2/006
Inventor 冯建峰王继军唐莺莹张捷
Owner FUDAN UNIV
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