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A kind of molecularly imprinted microsphere and its application method

A technology of molecularly imprinted microspheres and microspheres, which can be used in chemical instruments and methods, other chemical processes, color/spectral property measurement, etc., and can solve the problems of slow detection speed and complicated analysis steps.

Active Publication Date: 2020-11-24
CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can solve the problems of cumbersome analysis steps and slow detection speed of organophosphorus pesticide residues in the fields of environment, food and traditional Chinese medicine; both qualitative analysis and quantitative detection can be carried out

Method used

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  • A kind of molecularly imprinted microsphere and its application method
  • A kind of molecularly imprinted microsphere and its application method
  • A kind of molecularly imprinted microsphere and its application method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] A method for preparing organophosphorus pesticide residue magnetic molecularly imprinted microspheres, respectively using triazophos, fenthion, and quinthion as template molecules, and vinyl phosphate as a monofunctional monomer, according to the following steps:

[0077] (1) Preparation of superparamagnetic Fe by hydrothermal method 3 o 4 Nanoparticles:

[0078] 1.35g FeCl 3 ·6H 2 O, 3.60 g of sodium acetate and 1.00 g of polyethylene glycol were dissolved in 40 mL of ethylene glycol. Then the mixture was sonicated for 30 min, placed in a polytetrafluoroethylene-lined stainless steel autoclave, sealed, and heated to 200 ° C for 8 h. After magnetic control separation, wash with deionized water for 3 to 6 times, and vacuum dry at 50°C for 8 hours to obtain superparamagnetic Fe 3 o 4 nanoparticles.

[0079] (2) Preparation of Fe by sol suspension method 3 o 4 @CTAB @mSiO 2 Nanoparticles:

[0080] In 100 mL of deionized water, the superparamagnetic Fe 3 o 4 Na...

Embodiment 2

[0089] A method for preparing organophosphorus pesticide residue magnetic molecularly imprinted microspheres, respectively using triazophos, fenthion, and quinthion as template molecules, and using allyl phosphate as a monofunctional monomer, the following steps are carried out:

[0090] The method of steps (1)-(4) is the same as that of Example 1, and can be carried out step by step.

[0091] (5) Synthesis of magnetic molecularly imprinted microspheres of organophosphorus monofunctional monomers by surface imprinting polymerization:

[0092] This step is the same as step (5) of Example 1, except that the functional monomer is replaced by allyl phosphate.

[0093] Simultaneous preparation of Fe without template molecules 3 o 4 @mSiO 2 @NIPs microspheres (MNIPs) for comparative experiments of adsorption performance.

Embodiment 3

[0095] A method for preparing organophosphorus pesticide residue magnetic molecularly imprinted microspheres, respectively using triazophos, fenthion, and quinthion as template molecules, and ethylene phosphate and 1-octadecene as bifunctional monomers, according to Follow these steps:

[0096] The method of steps (1)-(4) is the same as that of Example 1, and can be carried out step by step.

[0097] (5) Synthesis of organophosphorus bifunctional monomer magnetic molecularly imprinted microspheres by surface imprinting polymerization:

[0098] This step is the same as step (5) of Example 1, except that one functional monomer is replaced by two functional monomers: vinyl phosphate and 1-octadecene.

[0099] Simultaneous preparation of Fe without template molecules 3 o 4 @mSiO 2 @NIPs microspheres (MNIPs) for comparative experiments of adsorption performance.

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Abstract

The invention relates to molecularly imprinted microspheres and application of the molecularly imprinted microspheres. According to the invention, an organophosphorus pesticide is taken as template molecules, and magnetic molecularly imprinted microspheres are prepared by taking ethylene phosphate and 1-octadecene as bifunctional monomers, and rapid qualitative and quantitative analysis of organophosphorus is realized through the color development effect of sodium molybdate. Sodium molybdate reacts with a phosphoric acid skeleton derived from ethylene phosphate and on the microsphere surfacesto form phosphorus molybdenum blue, without digesting organophosphorus into inorganic phosphorus, and color changes(color becomes light) or absorbance before and after the microspheres specifically adsorb organophosphorus pesticide residues is observed to realize qualitative analysis of naked-eye visualized color development of the organophosphorus pesticide residues and quantitative detection byspectrophotometry. The molecularly imprinted microspheres can realize color sensitivity recognition and on-site rapid screening of organophosphorus by the molecularly imprinted microspheres. The method disclosed by the invention has the advantages of large adsorption amount of the microspheres, high sensitivity and accuracy, no need for digesting organophosphorus, fast detection speed (not greaterthan 10min), low detection limit (1.0*10<-4> mmol / L) and the like.

Description

technical field [0001] The invention belongs to the technical field of detection of organophosphorus pesticide residues, and relates to a molecularly imprinted microsphere and a method for detecting organophosphorus pesticide residues; The application of rapid chromogenic analysis and detection of phosphorus pesticide residues. Background technique [0002] In agricultural production, organophosphorus pesticides are widely used in order to kill pests and increase yields, accounting for more than 70% of all pesticides, causing non-point source environmental pollution and seriously affecting food safety. In addition to high concentration exposure can cause acute poisoning, most organophosphorus pesticides show high toxicity after being absorbed by the human body. This is because organophosphate acts as an inhibitor of acetylcholinesterase, which will cause excessive accumulation of acetylcholine in the body. In order to fully guarantee food safety, it is urgent to develop eff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F292/00C08F230/02C08F210/14C08F2/44C08J9/28C08J9/26B01J20/28B01J20/26B01J20/30G01N21/31G01N21/29
CPCB01J20/268B01J20/28019C08F2/44C08F210/14C08F230/02C08F292/00C08J9/26C08J9/28C08J9/286C08J2351/10G01N21/29G01N21/31
Inventor 谢练武吴茂邓慧芸范亚军郭亚平卢丹青
Owner CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY
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