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A preparation method of porous nanofiber capable of maintaining disinfectant for a long time

A nanofiber and disinfectant technology, applied in fiber treatment, fiber type, fiber chemical characteristics, etc., can solve the problems of high cost, waste, and short sterilization time, and achieve long release time, large liquid storage volume, and simple operation Effect

Inactive Publication Date: 2021-07-09
江苏德鲁克生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Generally, disinfectants are highly volatile, and the effective sterilization time when applied to the wound is short, and the wound cannot be disinfected for a long time. It is necessary to repeatedly apply disinfectant to the wound, which not only causes waste due to high cost, but also
[0003] The use of nanofiber materials is an effective means of improving the antibacterial and disinfection time. Common methods for preparing nanofibers include electrospinning, template method, hydrothermal method, sea-island method and other technical processes, but there is no such technology in the market. Biodegradable nanofibers that can maintain disinfectants for a long time are produced. The inventor combined a large amount of research work and proposed a preparation method for porous nanofibers that can maintain disinfectants for a long time. The obtained hollow nanofibers can also be biodegradable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0014] A kind of preparation method of the porous nanofiber that can keep disinfectant for a long time, comprises the following steps:

[0015] S1, preparing polycaprolactone-titanium dioxide sol;

[0016] Dissolving polycaprolactone in chloroform solvent, then adding titanium dioxide particles, stirring magnetically, and then standing still to obtain a polycaprolactone-titanium dioxide sol with a content of 10%;

[0017] S2, electrospinning;

[0018] Take out 10 milliliters of the polycaprolactone-titanium dioxide sol obtained in step S1 and place it in a plastic syringe. A metal needle is installed at the front end of the plastic syringe, and then a high-voltage electrostatic power supply is connected, and the grounded aluminum foil is set as a negative pole. After adjusting to 12KV, lightly press the plastic syringe until the polycaprolactone-titanium dioxide sol flows out and then perform spinning treatment, and the spinning distance is 10 cm;

[0019] S3, making holes b...

Embodiment 1

[0024] A kind of preparation method of the porous nanofiber that can keep disinfectant for a long time, comprises the following steps:

[0025] S1, preparing polycaprolactone-titanium dioxide sol;

[0026] 0.5g of polycaprolactone was dissolved in 8g of chloroform solvent, then 0.05g of titanium dioxide particles were added, stirred by magnetic force for 4 hours, and then left to stand for 10 hours to obtain a polycaprolactone-titanium dioxide sol with a content of 10%;

[0027] S2, electrospinning;

[0028] Take out 8 milliliters of the polycaprolactone-titanium dioxide sol obtained in step S1 and place it in a plastic syringe. A metal needle is installed at the front end of the plastic syringe, and then a high-voltage electrostatic power supply is connected, and the grounded aluminum foil is set as a negative pole. After adjusting to 12KV, lightly press the plastic syringe until the polycaprolactone-titanium dioxide sol flows out and then perform spinning treatment, and the...

Embodiment 2

[0034] A kind of preparation method of the porous nanofiber that can keep disinfectant for a long time, comprises the following steps:

[0035] S1, preparing polycaprolactone-titanium dioxide sol;

[0036] 1g of polycaprolactone was dissolved in 9g of chloroform solvent, then 0.1g of titanium dioxide particles were added, stirred by magnetic force for 5 hours, and then left to stand for 12 hours to obtain a polycaprolactone-titanium dioxide sol with a content of 10%;

[0037] S2, electrospinning;

[0038] Take out 10 milliliters of the polycaprolactone-titanium dioxide sol obtained in step S1 and place it in a plastic syringe. A metal needle is installed at the front end of the plastic syringe, and then a high-voltage electrostatic power supply is connected, and the grounded aluminum foil is set as a negative pole. After adjusting to 12KV, lightly press the plastic syringe until the polycaprolactone-titanium dioxide sol flows out and then perform spinning treatment, and the s...

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Abstract

The invention discloses a method for preparing hollow nanofibers capable of keeping disinfectant for a long time, comprising the following steps: dissolving 1 g of polycaprolactone in 9 g of chloroform solvent, then adding 0.1 g of photocatalyst, and stirring and standing still Finally, polycaprolactone-titanium dioxide sol is obtained; a small amount of the obtained sol is taken out and placed in a plastic syringe, and a metal needle is installed at the front end of the plastic syringe, then the high-voltage electrostatic power supply is connected, and the grounding aluminum foil is set as the negative pole. Gently press the plastic syringe until the sol flows out before spinning; grind the spun fibers into pieces and place them in 500 ml of aqueous solution, stir them while irradiating them with ultraviolet light for 3 days, then filter them, and then dry them in a vacuum oven ; soak the dried nanofibers in a disinfectant to obtain a porous nanofiber substrate; the hollow biodegradable nanofibers obtained in the present invention have the characteristics of large liquid storage and long release time.

Description

technical field [0001] The invention relates to a preparation method of hollow nanofibers, in particular to a preparation method of biodegradable hollow nanofibers capable of maintaining disinfectant for a long time. Background technique [0002] Generally, disinfectants are highly volatile, and the effective sterilization time when applied to the wound is short, and the wound cannot be disinfected for a long time. It is necessary to repeatedly apply disinfectant to the wound, which not only causes waste due to high cost, but also [0003] The use of nanofiber materials is an effective means of improving the antibacterial and disinfection time. Common methods for preparing nanofibers include electrospinning, template method, hydrothermal method, sea-island method and other technical processes, but there is no such technology in the market. Biodegradable nanofibers that can retain disinfectants for a long time are produced. The inventor combined a large amount of research wor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F6/92D01F1/10D06M13/144D06M15/356D06M11/09D06M101/32
CPCD01F1/10D01F6/92D06M11/09D06M13/144D06M15/3562D06M2101/32
Inventor 常国庆陈磊
Owner 江苏德鲁克生物科技有限公司
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