Use of anthocyanin 3-[2-(xyloside)galactoside] as an active ingredient in the preparation of blood lipid-lowering drugs

A technology of blood lipid-lowering drugs and galactosides, which is applied in the directions of organic active ingredients, medical preparations containing active ingredients, and drug combinations, can solve the problem of few effective parts of traditional Chinese medicine compounds, and achieve the effect of reducing blood lipid levels.

Active Publication Date: 2020-09-22
JIANGSU VOCATIONAL COLLEGE OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Judging from the literature, recent studies on the pharmacological effects of active components of traditional Chinese medicine on lowering blood lipids mostly use the effective parts of single Chinese medicines, and seldom conduct research on the effective parts of traditional Chinese medicine compounds.

Method used

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  • Use of anthocyanin 3-[2-(xyloside)galactoside] as an active ingredient in the preparation of blood lipid-lowering drugs
  • Use of anthocyanin 3-[2-(xyloside)galactoside] as an active ingredient in the preparation of blood lipid-lowering drugs
  • Use of anthocyanin 3-[2-(xyloside)galactoside] as an active ingredient in the preparation of blood lipid-lowering drugs

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preparation example Construction

[0019] In the embodiment of the present invention, the preparation method of the self-made medicine that adopts comprises:

[0020] Preparation of anthocyanin 3-[2-(xyloside)galactoside]:

[0021] Take cornflower from Sheyang, Jiangsu, crush it, add 10 times the amount (by weight) of ethanol with a concentration of 70% (v / v) to reflux extract twice, 6 times and 4 times, each time for 2 hours, and combine the extracts , reclaim the solvent to a relative density of 1.2 fluid extracts, add water to dilute to 0.2g crude drug per milliliter, filter, and the filtrate is standby (recording total flavonoid content is 13.62mg / mL); pretreated macroporous adsorption resin, wet method Pack the column with a volume of 100mL (wet weight 66g, dry weight 18g), diameter-to-height ratio of 1:8, precisely absorb 400mL of the column solution, control the flow rate at 6mL / min, and then use 3 times the column volume Purified water and 20% (v / v) ethanol of 1 times the column volume were used to elu...

Embodiment 1

[0027] The self-made delphinidin 3-[2-(xyloside)galactoside]A is used as an active ingredient to prepare blood lipid-lowering drugs.

Embodiment 2

[0029] Anthocyanin 3-[2-(xyloside)galactoside] (as A) and cyanidin-3-O-glucoside (as B) obtained by self-made are used as active ingredients for the preparation of blood lipid-lowering drugs, The weight ratio of A to B is 4:1.

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Abstract

The invention discloses application of delphinin 3-[2-(xyloside)galactoside] as active ingredient to preparation of lipid-lowering drugs, and provides application of delphinin 3-[2-(xyloside)galactoside] and cyaniding-3-O-glucoside as active ingredients to preparation of lipid-lowering drugs. According to the application, delphinin 3-[2-(xyloside)galactoside] is sinly adopted or delphinin 3-[2-(xyloside)galactoside] and cyaniding-3-O-glucoside are reasonably matched to obtain two active ingredients for a synergistic effect, and animal experiments prove that application is capable of significantly reducing the blood lipid levels in mice, thereby providing a new pharmaceutical composition for lipid lowering for people.

Description

technical field [0001] The invention belongs to the technical field of drug combinations, and more specifically relates to the use of anthocyanin 3-[2-(xyloside)galactoside] as an active ingredient in the preparation of blood lipid-lowering drugs. Background technique [0002] The term anthocyanin was first proposed by Marguart in 1835 when it was used to name the blue extract from cornflower flowers, and it is now a general term for similar substances. Since the basic skeleton structure of anthocyanins is very similar to the flavonoid structure of 2-benzochromanone, anthocyanins are now collectively referred to as flavonoids. Anthocyanins refer to a series of C6-C3-C6 compounds formed by connecting two benzene rings (A- and B-rings) through the central three-carbon chain (C ring). Its ligand is anthocyanin. Due to the different substituents on the carbon positions of the B ring, various anthocyanins are formed. With the different types and quantities of sugars and organic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P3/06
CPCA61K31/7048A61P3/06A61K2300/00
Inventor 张小蒙周敏
Owner JIANGSU VOCATIONAL COLLEGE OF MEDICINE
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