Large field of view biological imaging, scanning and analysis device for rapid detection of circulating tumor cells

A bio-imaging and tumor cell technology, applied in the field of medical devices, can solve problems such as the inability to meet the needs of rapid and accurate detection of circulating tumor cells, and achieve the effects of isolating cross-contamination of samples, improving detection efficiency, and reducing costs

Pending Publication Date: 2019-02-15
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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Problems solved by technology

Therefore, it cannot meet the needs of rapid and accurate detection of circulating tumor cells.

Method used

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  • Large field of view biological imaging, scanning and analysis device for rapid detection of circulating tumor cells
  • Large field of view biological imaging, scanning and analysis device for rapid detection of circulating tumor cells
  • Large field of view biological imaging, scanning and analysis device for rapid detection of circulating tumor cells

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Embodiment Construction

[0032] The present invention will be further described in detail below in conjunction with the embodiments, so that those skilled in the art can implement it with reference to the description.

[0033] It should be understood that terms such as "having", "comprising" and "including" used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

[0034] like Figure 1-4As shown, a large-field bioimaging, scanning, and analyzing device for rapid detection of circulating tumor cells in this embodiment includes a large-area single-layer cell pushing system 3 and a large-field high-resolution reflective imaging system 4 And a small-field multispectral fluorescence microscopy imaging system5.

[0035] The large-area single-layer cell pusher system 3 is used to push the sample into a single layer of cells, and output a large-area slide 6 coated with a single layer of sample cells;

[0036] The large field of view and high resolution refl...

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Abstract

The invention discloses a large field of view biological imaging, scanning and analysis device for the rapid detection of circulating tumor cells, comprising a large-area single-layer cell pushing system, a large field of view high-resolution reflective imaging system, and a small field of view multi-spectral fluorescence microscopy imaging system. The large field of view high-resolution reflective imaging system comprises a large area array detector, an integrated control module, and an image processing module. The small field of view multi-spectral fluorescence microscopy imaging system comprises a supporting frame, an excitation light source module, an imaging light path module, a microscope objective, and a three-dimensional moving stage. According to the large field of view biologicalimaging, scanning and analysis device for rapid detection of circulating tumor cells, the detection efficiency is improved, the false positive is reduced, the detection time is shortened, the cost isreduced, and the sample cross-contamination is isolated compared with the existing detecting equipment for circulating tumor cells. The invention can realize full-automatic detection, scanning, imaging, and operation, is more convenient to use, and can also greatly reduce errors caused by manual intervention and subjective judgment.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a large field of view biological imaging, scanning and analysis device for rapid detection of circulating tumor cells. Background technique [0002] Circulating tumor cells are primary tumor cells that undergo epithelial-mesenchymal transition and other processes to obtain high invasiveness, fall off from the primary tissue or metastases, invade the surrounding stroma and enter the blood circulation system, and are easily transported to remote tissues and enter secondary viscera. Organs form metastases. At present, studies have proved that circulating tumor cells can be detected in the early stages of cancer, so the detection of circulating tumor cells is of great significance for early diagnosis and staging of tumors, individualized treatment and guidance, detection of curative effect and prognosis assessment, research on tumor metastasis mechanisms, etc. . In addition, the circ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/47G01N21/64G01N21/01
CPCG01N21/01G01N21/4738G01N21/6456
Inventor 唐玉国董文飞付威威张洋刘广兴尹焕才黎海文葛明峰
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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